faktor XIIa [Factor XIIa]

tematický
2
Termíny

aktivátor prekalikreinu
aktivovaný faktor XII
fragmenty Hagemanova faktoru
koagulační faktor XIIa

 

Activated Factor XII
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Hageman-Factor Fragments
Prekallikrein Activator

Perzistentní odkaz   https://www.medvik.cz/link/D015956
Definice

Aktivovaná forma faktoru XII. V počáteční fázi vnitřní dráhy hemokoagulace štěpí faktor XII kalikrein (s kofaktorem vysokomolekulárním kininogenem) na faktor XIIa. Faktor XIIa je pak dále štěpen kalikreinem, plazminem a trypsinem za vzniku menších fragmentů faktoru XII (fragmenty Hagemanova faktoru). Tyto fragmenty zvyšují aktivitu prekalikreinu na kalikrein, ale snižují prokoagulační aktivitu faktoru XII.

Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.

Anotace
/defic = FACTOR XII DEFICIENCY
DUI
D015956 MeSH Prohlížeč
CUI
M0024400
Předchozí užití
Serine Proteinases (1988-1989); Factor XII (1966-1989); Peptide Fragments (1979-1987)
Historická pozn.
90
Veřejná pozn.
90

D Chemikálie a léčiva
D08.811 enzymy 1 547
D08.811.277 hydrolasy 475
D08.811.277.656 proteasy 559
D08.811.277.656.300 endopeptidasy 211
D08.811.277.656.300.760 serinové endopeptidasy 138
D08.811.277.656.300.760.030 akrosin 14
D08.811.277.656.300.760.066 kathepsin G 4
D08.811.277.656.300.760.103 chymasy 5
D08.811.277.656.300.760.176 chymotrypsin 133
D08.811.277.656.300.760.198 komplement - faktor B 3
D08.811.277.656.300.760.200 komplement - faktor D 5
D08.811.277.656.300.760.210 komplement - faktor I
D08.811.277.656.300.760.247 endopeptidasa K 7
D08.811.277.656.300.760.284 enteropeptidasa 3
D08.811.277.656.300.760.300 faktor VIIa 109
D08.811.277.656.300.760.310 faktor IXa 6
D08.811.277.656.300.760.315 faktor Xa 189
D08.811.277.656.300.760.320 faktor XIa 7
D08.811.277.656.300.760.324 faktor XIIa 2
D08.811.277.656.300.760.330 plasmin 44
D08.811.277.656.300.760.353 furin 2
D08.811.277.656.300.760.397 granzymy 11
D08.811.277.656.300.760.420 serinová proteasa HTRA1 1
D08.811.277.656.300.760.431 serinová proteasa HTRA2
D08.811.277.656.300.760.442 kalikreiny 39
D08.811.277.656.300.760.471 laktoferrin 32
D08.811.277.656.300.760.530 myeloblastin 8
D08.811.277.656.300.760.560 pankreatická elastasa 93
D08.811.277.656.300.760.635 aktivátory plazminogenu 56
D08.811.277.656.300.760.637 prolyloligopeptidasy 3
D08.811.277.656.300.760.638 pronasa 4
D08.811.277.656.300.760.640 proproteinkonvertasa 1 4
D08.811.277.656.300.760.646 proproteinkonvertasa 2
D08.811.277.656.300.760.648 proproteinkonvertasa 5
D08.811.277.656.300.760.718 proproteinkonvertasa subtilisin/kexin typu 9 269
D08.811.277.656.300.760.753 protein reelin
D08.811.277.656.300.760.787 subtilisiny 7
D08.811.277.656.300.760.855 trombin 228
D08.811.277.656.300.760.875 tkáňový aktivátor plazminogenu 237
D08.811.277.656.300.760.895 trypsin 257
D08.811.277.656.300.760.902 tryptasy 35
D08.811.277.656.300.760.910 aktivátor plazminogenu urokinázového typu 61
D08.811.277.656.300.760.955 venombin A 1
D08.811.277.656.959 serinové proteasy 21
D08.811.277.656.959.350 serinové endopeptidasy 138
D08.811.277.656.959.350.030 akrosin 14
D08.811.277.656.959.350.066 kathepsin G 4
D08.811.277.656.959.350.103 chymasy 5
D08.811.277.656.959.350.176 chymotrypsin 133
D08.811.277.656.959.350.198 komplement - faktor B 3
D08.811.277.656.959.350.200 komplement - faktor D 5
D08.811.277.656.959.350.210 komplement - faktor I
D08.811.277.656.959.350.247 endopeptidasa K 7
D08.811.277.656.959.350.284 enteropeptidasa 3
D08.811.277.656.959.350.300 faktor VIIa 109
D08.811.277.656.959.350.310 faktor IXa 6
D08.811.277.656.959.350.315 faktor Xa 189
D08.811.277.656.959.350.320 faktor XIa 7
D08.811.277.656.959.350.324 faktor XIIa 2
D08.811.277.656.959.350.330 plasmin 44
D08.811.277.656.959.350.353 furin 2
D08.811.277.656.959.350.397 granzymy 11
D08.811.277.656.959.350.420 serinová proteasa HTRA1 1
D08.811.277.656.959.350.431 serinová proteasa HTRA2
D08.811.277.656.959.350.442 kalikreiny 39
D08.811.277.656.959.350.471 laktoferrin 32
D08.811.277.656.959.350.530 myeloblastin 8
D08.811.277.656.959.350.560 pankreatická elastasa 93
D08.811.277.656.959.350.635 aktivátory plazminogenu 56
D08.811.277.656.959.350.638 pronasa 4
D08.811.277.656.959.350.640 proproteinkonvertasa 1 4
D08.811.277.656.959.350.646 proproteinkonvertasa 2
D08.811.277.656.959.350.648 proproteinkonvertasa 5
D08.811.277.656.959.350.718 proproteinkonvertasa subtilisin/kexin typu 9 269
D08.811.277.656.959.350.753 protein reelin
D08.811.277.656.959.350.787 subtilisiny 7
D08.811.277.656.959.350.855 trombin 228
D08.811.277.656.959.350.875 tkáňový aktivátor plazminogenu 237
D08.811.277.656.959.350.895 trypsin 257
D08.811.277.656.959.350.902 tryptasy 35
D08.811.277.656.959.350.910 aktivátor plazminogenu urokinázového typu 61
D08.811.277.656.959.350.955 venombin A 1
D12.776 proteiny 2 575
D12.776.124 krevní proteiny 909
D12.776.124.125 koagulační faktory 332
D12.776.124.125.450 faktor XII 18
D12.776.124.125.450.324 faktor XIIa 2
D23.119.450 faktor XII 18
D23.119.450.324 faktor XIIa 2