Factor XIIa [faktor XIIa]
- Terms
-
aktivátor prekalikreinu
aktivovaný faktor XII
fragmenty Hagemanova faktoru
koagulační faktor XIIa
-
Activated Factor XII
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Hageman-Factor Fragments
Prekallikrein Activator
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
- Annotation
- /defic = FACTOR XII DEFICIENCY
- DUI
- D015956 MeSH Browser
- CUI
- M0024400
- Previous indexing
- Serine Proteinases (1988-1989); Factor XII (1966-1989); Peptide Fragments (1979-1987)
- History note
- 90
- Public note
- 90
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