Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort

EF. Osimo, J. Stochl, S. Zammit, G. Lewis, PB. Jones, GM. Khandaker,

. 2020 ; 96 (-) : 152143. [pub] 20191031

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028625

Grantová podpora
Wellcome Trust - United Kingdom
G9815508 Medical Research Council - United Kingdom
MR/L010305/1 Medical Research Council - United Kingdom
R01 DK077659 NIDDK NIH HHS - United States
08426812/Z/07/Z Wellcome Trust - United Kingdom
201486/Z/16/Z Wellcome Trust - United Kingdom
MC_PC_17213 Medical Research Council - United Kingdom
095844/Z/11/Z Wellcome Trust - United Kingdom
088869/Z/09/Z Wellcome Trust - United Kingdom
08426812/Z/07/Z Wellcome Trust - United Kingdom
G0801456 Medical Research Council - United Kingdom
102215/2/13/2 Wellcome Trust - United Kingdom

BACKGROUND: Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals are scarce. METHODS: We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort. RESULTS: Using Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identified four population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low (N=463, 29.5%); persistently high (N=371, 24%); decreasing (N=360, 23%); increasing (N=367, 23.5%). The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood. Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared with those with persistently low CRP; adjusted odds ratio (OR)=3.78 (95% Confidence Interval (CI), 1.46-9.81; p=0.006). The odds of moderate/severe depression were also increased for the persistently high CRP group, but this was not statistically significant; OR=2.54 (95% CI, 0.90-7.16). LIMITATIONS: Repeat CRP measures were available for a subset, who may not be representative of all cohort participants. CONCLUSIONS: The results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20028625
003      
CZ-PrNML
005      
20210114154506.0
007      
ta
008      
210105s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.comppsych.2019.152143 $2 doi
035    __
$a (PubMed)31707310
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Osimo, Emanuele F $u Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK; Institute of Clinical Sciences, Imperial College London, London, UK. Electronic address: efo22@cam.ac.uk.
245    10
$a Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort / $c EF. Osimo, J. Stochl, S. Zammit, G. Lewis, PB. Jones, GM. Khandaker,
520    9_
$a BACKGROUND: Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals are scarce. METHODS: We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort. RESULTS: Using Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identified four population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low (N=463, 29.5%); persistently high (N=371, 24%); decreasing (N=360, 23%); increasing (N=367, 23.5%). The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood. Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared with those with persistently low CRP; adjusted odds ratio (OR)=3.78 (95% Confidence Interval (CI), 1.46-9.81; p=0.006). The odds of moderate/severe depression were also increased for the persistently high CRP group, but this was not statistically significant; OR=2.54 (95% CI, 0.90-7.16). LIMITATIONS: Repeat CRP measures were available for a subset, who may not be representative of all cohort participants. CONCLUSIONS: The results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a C-reaktivní protein $x metabolismus $7 D002097
650    _2
$a dítě $7 D002648
650    _2
$a kohortové studie $7 D015331
650    _2
$a deprese $x krev $x epidemiologie $7 D003863
650    _2
$a depresivní poruchy $x krev $x epidemiologie $7 D003866
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a longitudinální studie $7 D008137
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a prospektivní studie $7 D011446
650    _2
$a riziko $7 D012306
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Stochl, Jan $u Department of Psychiatry, University of Cambridge, Cambridge, UK; Department of Kinanthropology, Charles University, Prague, Czech Republic.
700    1_
$a Zammit, Stan $u Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Division of Psychiatry, University College London, London, UK.
700    1_
$a Lewis, Glyn $u Division of Psychiatry, University College London, London, UK.
700    1_
$a Jones, Peter B $u Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
700    1_
$a Khandaker, Golam M $u Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
773    0_
$w MED00001208 $t Comprehensive psychiatry $x 1532-8384 $g Roč. 96, č. - (2020), s. 152143
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31707310 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20210105 $b ABA008
991    __
$a 20210114154503 $b ABA008
999    __
$a ok $b bmc $g 1608960 $s 1119805
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 96 $c - $d 152143 $e 20191031 $i 1532-8384 $m Comprehensive psychiatry $n Compr Psychiatry $x MED00001208
GRA    __
$p Wellcome Trust $2 United Kingdom
GRA    __
$a G9815508 $p Medical Research Council $2 United Kingdom
GRA    __
$a MR/L010305/1 $p Medical Research Council $2 United Kingdom
GRA    __
$a R01 DK077659 $p NIDDK NIH HHS $2 United States
GRA    __
$a 08426812/Z/07/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a 201486/Z/16/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a MC_PC_17213 $p Medical Research Council $2 United Kingdom
GRA    __
$a 095844/Z/11/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a 088869/Z/09/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a 08426812/Z/07/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a G0801456 $p Medical Research Council $2 United Kingdom
GRA    __
$a 102215/2/13/2 $p Wellcome Trust $2 United Kingdom
LZP    __
$a Pubmed-20210105

Najít záznam

Citační ukazatele

Možnosti archivace