• Je něco špatně v tomto záznamu ?

Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples

C. Chen, P. Lohavanichbutr, Y. Zhang, JR. Houck, MP. Upton, B. Abedi-Ardekani, A. Agudo, W. Ahrens, L. Alemany, D. Anantharaman, DI. Conway, ND. Futran, I. Holcatova, K. Günther, BT. Hansen, CM. Healy, D. Itani, K. Kjaerheim, MM. Monroe, PJ....

. 2020 ; 100 (-) : 104487. [pub] 20191210

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028676

Grantová podpora
T32 DC000018 NIDCD NIH HHS - United States
R01 CA177736 NCI NIH HHS - United States
T32 DC005356 NIDCD NIH HHS - United States
U24 CA210993 NCI NIH HHS - United States
P30 CA042014 NCI NIH HHS - United States
P50 CA097248 NCI NIH HHS - United States
T42 OH008455 NIOSH CDC HHS - United States
P30 CA046592 NCI NIH HHS - United States
P30 CA015704 NCI NIH HHS - United States
K12 RR023265 NCRR NIH HHS - United States
R01 CA095419 NCI NIH HHS - United States

OBJECTIVES: To test the performance of an oral cancer prognostic 13-gene signature for the prediction of survival of patients diagnosed with HPV-negative and p16-negative oral cavity cancer. MATERIALS AND METHODS: Diagnostic formalin-fixed paraffin-embedded oral cavity cancer tumor samples were obtained from the Fred Hutchinson Cancer Research Center/University of Washington, University of Calgary, University of Michigan, University of Utah, and seven ARCAGE study centers coordinated by the International Agency of Research on Cancer. RNA from 638 Human Papillomavirus (HPV)-negative and p16-negative samples was analyzed for the 13 genes using a NanoString assay. Ridge-penalized Cox regressions were applied to samples randomly split into discovery and validation sets to build models and evaluate the performance of the 13-gene signature in predicting 2-year oral cavity cancer-specific survival overall and separately for patients with early and late stage disease. RESULTS: Among AJCC stage I/II patients, including the 13-gene signature in the model resulted in substantial improvement in the prediction of 2-year oral cavity cancer-specific survival. For models containing age and sex with and without the 13-gene signature score, the areas under the Receiver Operating Characteristic Curve (AUC) and partial AUC were 0.700 vs. 0.537 (p < 0.001), and 0.046 vs. 0.018 (p < 0.001), respectively. Improvement in predicting prognosis for AJCC stage III/IV disease also was observed, but to a lesser extent. CONCLUSIONS: If confirmed using tumor samples from a larger number of early stage oral cavity cancer patients, the 13-gene signature may inform personalized treatment of early stage HPV-negative and p16-negative oral cavity cancer patients.

Cancer Epidemiology Research Program Catalan Institute of Oncology IDIBELL Avinguda de la Granvia 199 08908 L'Hospitalet de Llobregat Barcelona Spain

Cancer Registry of Norway Ullernchausseen 64 0379 Oslo Norway

Department of Epidemiology University of Washington 1959 NE Pacific St Seattle WA USA

Department of Otolaryngology Head and Neck Surgery University of Washington 1959 NE Pacific St Seattle WA USA

Department of Pathology University of Washington 1959 NE Pacific St Seattle WA USA

Dublin Dental University Hospital Trinity College Dublin Lincoln Pl Dublin Ireland

Epidemiology and Public Health Centro de Investigación Biomédica en Red Epidemiología y Salud Pública Instituto de Salud Carlos 3 Madrid Spain

Icahn School of Medicine at Mount Sinai 1 Gustave L Levy Pl New York NY USA

Institute of Hygiene and Epidemiology 1st Faculty of Medicine Opletalova 38 110 00 Staré Město Charles University Prague Czech Republic

Institute of Statistics Bremen University Achterstraße 30 28359 Bremen Germany

International Agency of Research on Cancer 150 Cours Albert Thomas Lyon France

Leibniz Institute for Prevention Research and Epidemiology BIPS Bremen Germany

Oral and Maxillofacial Surgery The University of Hong Kong Pok Fu Lam Hong Kong

Program in Epidemiology Division of Public Health Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Ave N Seattle WA USA

Rajiv Gandhi Centre for Biotechnology Melarannoor Road Thycaud Thiruvananthapuram India

School of Medicine Dentistry and Nursing University of Glasgow University Avenue Glasgow UK

Section of Otolaryngology Head and Neck Surgery Cumming School of Medicine University of Calgary 3330 Hospital Dr NW Calgary Alberta Canada

University of Michigan 500 S State St Ann Arbor MI USA

University of Utah 201 Presidents Cir Salt Lake City UT USA

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20028676
003      
CZ-PrNML
005      
20210114154659.0
007      
ta
008      
210105s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.oraloncology.2019.104487 $2 doi
035    __
$a (PubMed)31835136
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Chen, Chu $u Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St, Seattle, WA, USA; Department of Otolaryngology -- Head and Neck Surgery, University of Washington, 1959, NE Pacific St, Seattle, WA, USA. Electronic address: cchen@fredhutch.org.
245    10
$a Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples / $c C. Chen, P. Lohavanichbutr, Y. Zhang, JR. Houck, MP. Upton, B. Abedi-Ardekani, A. Agudo, W. Ahrens, L. Alemany, D. Anantharaman, DI. Conway, ND. Futran, I. Holcatova, K. Günther, BT. Hansen, CM. Healy, D. Itani, K. Kjaerheim, MM. Monroe, PJ. Thomson, BL. Witt, S. Nakoneshny, LA. Peterson, SM. Schwartz, KR. Zarins, M. Hashibe, P. Brennan, LS. Rozek, G. Wolf, JC. Dort, P. Wang,
520    9_
$a OBJECTIVES: To test the performance of an oral cancer prognostic 13-gene signature for the prediction of survival of patients diagnosed with HPV-negative and p16-negative oral cavity cancer. MATERIALS AND METHODS: Diagnostic formalin-fixed paraffin-embedded oral cavity cancer tumor samples were obtained from the Fred Hutchinson Cancer Research Center/University of Washington, University of Calgary, University of Michigan, University of Utah, and seven ARCAGE study centers coordinated by the International Agency of Research on Cancer. RNA from 638 Human Papillomavirus (HPV)-negative and p16-negative samples was analyzed for the 13 genes using a NanoString assay. Ridge-penalized Cox regressions were applied to samples randomly split into discovery and validation sets to build models and evaluate the performance of the 13-gene signature in predicting 2-year oral cavity cancer-specific survival overall and separately for patients with early and late stage disease. RESULTS: Among AJCC stage I/II patients, including the 13-gene signature in the model resulted in substantial improvement in the prediction of 2-year oral cavity cancer-specific survival. For models containing age and sex with and without the 13-gene signature score, the areas under the Receiver Operating Characteristic Curve (AUC) and partial AUC were 0.700 vs. 0.537 (p < 0.001), and 0.046 vs. 0.018 (p < 0.001), respectively. Improvement in predicting prognosis for AJCC stage III/IV disease also was observed, but to a lesser extent. CONCLUSIONS: If confirmed using tumor samples from a larger number of early stage oral cavity cancer patients, the 13-gene signature may inform personalized treatment of early stage HPV-negative and p16-negative oral cavity cancer patients.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a plocha pod křivkou $7 D019540
650    _2
$a nádorové biomarkery $x genetika $7 D014408
650    _2
$a spinocelulární karcinom $x genetika $x metabolismus $x patologie $7 D002294
650    _2
$a inhibitor p16 cyklin-dependentní kinasy $x metabolismus $7 D019941
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a stanovení celkové genové exprese $x metody $7 D020869
650    _2
$a lidský papilomavirus 16 $x izolace a purifikace $7 D052162
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a nádory úst $x genetika $x metabolismus $x patologie $7 D009062
650    _2
$a staging nádorů $7 D009367
650    _2
$a zalévání tkání do parafínu $7 D016612
650    _2
$a sekvenční analýza RNA $7 D017423
650    _2
$a analýza přežití $7 D016019
650    _2
$a fixace tkání $7 D016707
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Lohavanichbutr, Pawadee $u Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, USA.
700    1_
$a Zhang, Yuzheng $u Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, USA.
700    1_
$a Houck, John R $u Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, USA.
700    1_
$a Upton, Melissa P $u Department of Pathology, University of Washington, 1959 NE Pacific St, Seattle, WA, USA.
700    1_
$a Abedi-Ardekani, Behnoush $u International Agency of Research on Cancer, 150 Cours Albert Thomas, Lyon, France.
700    1_
$a Agudo, Antonio $u Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, Avinguda de la Granvia, 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.
700    1_
$a Ahrens, Wolfgang $u Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany; Institute of Statistics, Bremen University, Achterstraße 30, 28359 Bremen, Germany.
700    1_
$a Alemany, Laia $u Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, Avinguda de la Granvia, 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain; Epidemiology and Public Health, Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
700    1_
$a Anantharaman, Devasena $u Rajiv Gandhi Centre for Biotechnology, Melarannoor Road, Thycaud, Thiruvananthapuram, India.
700    1_
$a Conway, David I $u School of Medicine, Dentistry, and Nursing, University of Glasgow, University Avenue, Glasgow, UK.
700    1_
$a Futran, Neal D $u Department of Otolaryngology -- Head and Neck Surgery, University of Washington, 1959, NE Pacific St, Seattle, WA, USA.
700    1_
$a Holcatova, Ivana $u Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Opletalova 38, 110 00 Staré Město, Charles University, Prague, Czech Republic.
700    1_
$a Günther, Kathrin $u Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
700    1_
$a Hansen, Bo T $u Cancer Registry of Norway, Ullernchausseen 64, 0379 Oslo, Norway.
700    1_
$a Healy, Claire M $u Dublin Dental University Hospital, Trinity College Dublin, Lincoln Pl, Dublin, Ireland.
700    1_
$a Itani, Doha $u Section of Otolaryngology -- Head & Neck Surgery, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary Alberta, Canada.
700    1_
$a Kjaerheim, Kristina $u Cancer Registry of Norway, Ullernchausseen 64, 0379 Oslo, Norway.
700    1_
$a Monroe, Marcus M $u University of Utah, 201 Presidents Cir, Salt Lake City, UT, USA.
700    1_
$a Thomson, Peter J $u Oral & Maxillofacial Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.
700    1_
$a Witt, Benjamin L $u University of Utah, 201 Presidents Cir, Salt Lake City, UT, USA.
700    1_
$a Nakoneshny, Steven $u Section of Otolaryngology -- Head & Neck Surgery, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary Alberta, Canada.
700    1_
$a Peterson, Lisa A $u University of Michigan, 500 S State St, Ann Arbor, MI, USA.
700    1_
$a Schwartz, Stephen M $u Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St, Seattle, WA, USA.
700    1_
$a Zarins, Katie R $u University of Michigan, 500 S State St, Ann Arbor, MI, USA.
700    1_
$a Hashibe, Mia $u University of Utah, 201 Presidents Cir, Salt Lake City, UT, USA.
700    1_
$a Brennan, Paul $u International Agency of Research on Cancer, 150 Cours Albert Thomas, Lyon, France.
700    1_
$a Rozek, Laura S $u University of Michigan, 500 S State St, Ann Arbor, MI, USA.
700    1_
$a Wolf, Gregory $u University of Michigan, 500 S State St, Ann Arbor, MI, USA.
700    1_
$a Dort, Joseph C $u Section of Otolaryngology -- Head & Neck Surgery, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary Alberta, Canada.
700    1_
$a Wang, Pei $u Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA.
773    0_
$w MED00003631 $t Oral oncology $x 1879-0593 $g Roč. 100, č. - (2020), s. 104487
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31835136 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20210105 $b ABA008
991    __
$a 20210114154655 $b ABA008
999    __
$a ok $b bmc $g 1609011 $s 1119856
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 100 $c - $d 104487 $e 20191210 $i 1879-0593 $m Oral oncology $n Oral Oncol $x MED00003631
GRA    __
$a T32 DC000018 $p NIDCD NIH HHS $2 United States
GRA    __
$a R01 CA177736 $p NCI NIH HHS $2 United States
GRA    __
$a T32 DC005356 $p NIDCD NIH HHS $2 United States
GRA    __
$a U24 CA210993 $p NCI NIH HHS $2 United States
GRA    __
$a P30 CA042014 $p NCI NIH HHS $2 United States
GRA    __
$a P50 CA097248 $p NCI NIH HHS $2 United States
GRA    __
$a T42 OH008455 $p NIOSH CDC HHS $2 United States
GRA    __
$a P30 CA046592 $p NCI NIH HHS $2 United States
GRA    __
$a P30 CA015704 $p NCI NIH HHS $2 United States
GRA    __
$a K12 RR023265 $p NCRR NIH HHS $2 United States
GRA    __
$a R01 CA095419 $p NCI NIH HHS $2 United States
LZP    __
$a Pubmed-20210105

Najít záznam

Citační ukazatele

Možnosti archivace