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Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
IS. Chuma, C. Roos, A. Atickem, T. Bohm, D. Anthony Collins, L. Grillová, LK. Hallmaier-Wacker, RR. Kazwala, JD. Keyyu, S. Lüert, U. Maloueki, J. Oppelt, KJ. Petrželková, A. Piel, FA. Stewart, D. Šmajs, S. Knauf,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
Springer Nature OA/Free Journals
od 2011-12-01
- MeSH
- Cercopithecus aethiops mikrobiologie MeSH
- Cercopithecus mikrobiologie MeSH
- druhová specificita MeSH
- feces mikrobiologie MeSH
- fylogeneze MeSH
- genetická variace MeSH
- genetické asociační studie MeSH
- Gorilla gorilla mikrobiologie MeSH
- hostitelská specificita * MeSH
- infekce bakteriemi rodu Treponema epidemiologie mikrobiologie přenos veterinární MeSH
- jednonukleotidový polymorfismus MeSH
- multilokusová sekvenční typizace MeSH
- nemoci lidoopů epidemiologie mikrobiologie přenos MeSH
- nemoci opic epidemiologie mikrobiologie přenos MeSH
- Papio anubis mikrobiologie MeSH
- Papio cynocephalus mikrobiologie MeSH
- Treponema klasifikace genetika izolace a purifikace MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Kongo MeSH
- Tanzanie MeSH
In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
African Parks Odzala Kokoua National Park Brazzaville Republic of the Congo
Department of Biology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Zoological Sciences Addis Ababa University Addis Ababa Ethiopia
Jane Goodall Institute Kigoma Tanzania
Citace poskytuje Crossref.org
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- $a Chuma, Idrissa S $u Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany. Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany. Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania.
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- $a In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
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