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Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
IS. Chuma, C. Roos, A. Atickem, T. Bohm, D. Anthony Collins, L. Grillová, LK. Hallmaier-Wacker, RR. Kazwala, JD. Keyyu, S. Lüert, U. Maloueki, J. Oppelt, KJ. Petrželková, A. Piel, FA. Stewart, D. Šmajs, S. Knauf,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
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- MeSH
- Chlorocebus aethiops microbiology MeSH
- Cercopithecus microbiology MeSH
- Species Specificity MeSH
- Feces microbiology MeSH
- Phylogeny MeSH
- Genetic Variation MeSH
- Genetic Association Studies MeSH
- Gorilla gorilla microbiology MeSH
- Host Specificity * MeSH
- Treponemal Infections epidemiology microbiology transmission veterinary MeSH
- Polymorphism, Single Nucleotide MeSH
- Multilocus Sequence Typing MeSH
- Ape Diseases epidemiology microbiology transmission MeSH
- Monkey Diseases epidemiology microbiology transmission MeSH
- Papio anubis microbiology MeSH
- Papio cynocephalus microbiology MeSH
- Treponema classification genetics isolation & purification MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Congo MeSH
- Tanzania MeSH
In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
African Parks Odzala Kokoua National Park Brazzaville Republic of the Congo
Department of Biology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Zoological Sciences Addis Ababa University Addis Ababa Ethiopia
Jane Goodall Institute Kigoma Tanzania
References provided by Crossref.org
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- $a Chuma, Idrissa S $u Work Group Neglected Tropical Diseases, Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany. Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany. Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania.
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- $a Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates / $c IS. Chuma, C. Roos, A. Atickem, T. Bohm, D. Anthony Collins, L. Grillová, LK. Hallmaier-Wacker, RR. Kazwala, JD. Keyyu, S. Lüert, U. Maloueki, J. Oppelt, KJ. Petrželková, A. Piel, FA. Stewart, D. Šmajs, S. Knauf,
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- $a In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
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- $a Roos, Christian $u Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany. Gene Bank of Primates, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
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