Syndrom diabetické nohy patří k nejčastějším a nejzávažnějším komplikacím diabetu. Vzhledem k multifaktoriální etiologii je však terapie chronických defektů u diabetiků velmi obtížná. U nehojících se defektů bez osteomyelitidy a bez kritické ischemie je možné využít acellulární porcinní dermis pro urychlení hojení rány. Hlavní výhodou acellulární porcinní dermis je dlouhodobá skladovatelnost v sušeném stavu a velmi dobrá dostupnost. V naší pilotní studii provedené na 14 pacientech jsme zjistili, že tato léčba je u pacientů s povrchovějšími ulceracemi bez známek infekce účinnější než terapie xenotransplantáty a je vhodnou alternativou použití moderních umělých kožních náhrad. Nebyly pozorovány žádné závažné nežádoucí účinky této léčby.

Diabetic foot disease is one of the most common and most severe complications of diabetes. Aetiology of chronic ulcers is multifactorial and adequate therapy is often very difficult. Acellular porcine dermis could be used to treat chronic wounds with no signs of osteomyelitis and without critical ischaemia. The main advantages of acellular porcine dermis are its ability to be stored for long periods in dried form and its availability. In accordance with the results of our pilot study performed on 14 patients, the use of acellular porcine dermis in therapy of superficial non-infected ulcers was more efficient than with xenografts and is an appropriate alternative to modern bioengineered skin substitutes. We did not observe any serious adverse effects of this treatment.Diabetic foot disease is one of the most common and most severe complications of diabetes. Aetiology of chronic ulcers is multifactorial and adequate therapy is often very difficult. Acellular porcine dermis could be used to treat chronic wounds with no signs of osteomyelitis and without critical ischaemia. The main advantages of acellular porcine dermis are its ability to be stored for long periods in dried form and its availability. In accordance with the results of our pilot study performed on 14 patients, the use of acellular porcine dermis in therapy of superficial non-infected ulcers was more efficient than with xenografts and is an appropriate alternative to modern bioengineered skin substitutes. We did not observe any serious adverse effects of this treatment.

Centrum diabetologie IKEM Praha

Acellular porcine dermis in local treatment of diabetic food syndrome

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