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Peptide Channeling: The Key to MHC Class I Immunosurveillance?

JW. Yewdell, D. Dersh, R. Fåhraeus,

. 2019 ; 29 (12) : 929-939. [pub] 20191029

Language English Country Great Britain

Document type Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc20025472

MHC class I presentation of short peptides enables CD8+ T cell (TCD8+) immunosurveillance of tumors and intracellular pathogens. A key feature of the class I pathway is that the immunopeptidome is highly skewed from the cellular degradome, indicating high selectivity of the access of protease-generated peptides to class I molecules. Similarly, in professional antigen-presenting cells, peptides from minute amounts of proteins introduced into the cytosol outcompete an overwhelming supply of constitutively generated peptides. Here, we propose that antigen processing is based on substrate channeling and review recent studies from the antigen processing and cell biology fields that provide a starting point for testing this hypothesis.

References provided by Crossref.org

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