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Eye movements in ephedrone-induced parkinsonism

C. Bonnet, J. Rusz, M. Megrelishvili, T. Sieger, O. Matoušková, M. Okujava, H. Brožová, T. Nikolai, J. Hanuška, M. Kapianidze, N. Mikeladze, N. Botchorishvili, I. Khatiashvili, M. Janelidze, T. Serranová, O. Fiala, J. Roth, J. Bergquist, R. Jech,...

. 2014 ; 9 (8) : e104784. [pub] 20140812

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16010755

Grant support
NT12282 MZ0 CEP Register
NT12288 MZ0 CEP Register

Patients with ephedrone parkinsonism (EP) show a complex, rapidly progressive, irreversible, and levodopa non-responsive parkinsonian and dystonic syndrome due to manganese intoxication. Eye movements may help to differentiate parkinsonian syndromes providing insights into which brain networks are affected in the underlying disease, but they have never been systematically studied in EP. Horizontal and vertical eye movements were recorded in 28 EP and compared to 21 Parkinson's disease (PD) patients, and 27 age- and gender-matched healthy subjects using standardized oculomotor tasks with infrared videooculography. EP patients showed slow and hypometric horizontal saccades, an increased occurrence of square wave jerks, long latencies of vertical antisaccades, a high error rate in the horizontal antisaccade task, and made more errors than controls when pro- and antisaccades were mixed. Based on oculomotor performance, a direct differentiation between EP and PD was possible only by the velocity of horizontal saccades. All remaining metrics were similar between both patient groups. EP patients present extensive oculomotor disturbances probably due to manganese-induced damage to the basal ganglia, reflecting their role in oculomotor system.

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$a Eye movements in ephedrone-induced parkinsonism / $c C. Bonnet, J. Rusz, M. Megrelishvili, T. Sieger, O. Matoušková, M. Okujava, H. Brožová, T. Nikolai, J. Hanuška, M. Kapianidze, N. Mikeladze, N. Botchorishvili, I. Khatiashvili, M. Janelidze, T. Serranová, O. Fiala, J. Roth, J. Bergquist, R. Jech, S. Rivaud-Péchoux, B. Gaymard, E. Růžička,
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$a Patients with ephedrone parkinsonism (EP) show a complex, rapidly progressive, irreversible, and levodopa non-responsive parkinsonian and dystonic syndrome due to manganese intoxication. Eye movements may help to differentiate parkinsonian syndromes providing insights into which brain networks are affected in the underlying disease, but they have never been systematically studied in EP. Horizontal and vertical eye movements were recorded in 28 EP and compared to 21 Parkinson's disease (PD) patients, and 27 age- and gender-matched healthy subjects using standardized oculomotor tasks with infrared videooculography. EP patients showed slow and hypometric horizontal saccades, an increased occurrence of square wave jerks, long latencies of vertical antisaccades, a high error rate in the horizontal antisaccade task, and made more errors than controls when pro- and antisaccades were mixed. Based on oculomotor performance, a direct differentiation between EP and PD was possible only by the velocity of horizontal saccades. All remaining metrics were similar between both patient groups. EP patients present extensive oculomotor disturbances probably due to manganese-induced damage to the basal ganglia, reflecting their role in oculomotor system.
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$a Rusz, Jan $u Department of Neurology and Centre of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic. $7 xx0093732
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$a Megrelishvili, Marika $u Department of Neurology, S. Khechinashvili University Clinic, Tbilisi, Georgia; Institute of Medical Research, Ilia State University, Tbilisi, Georgia.
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$a Matoušková, Olga $u Department of Neurology and Centre of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
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$a Okujava, Michael $u Research Institute of Clinical Medicine, Tbilisi, Georgia.
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