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Heart Rate Influence on the QT Variability Risk Factors

I. Andršová, K. Hnatkova, M. Šišáková, O. Toman, P. Smetana, KM. Huster, P. Barthel, T. Novotný, G. Schmidt, M. Malik,

. 2020 ; 10 (12) : . [pub] 20201216

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21001527

Grantová podpora
NH/16/2/32499 British Heart Foundation - United Kingdom
FNBr/65269705 Ministerstvo Zdravotnictví Ceské Republiky
MUNI/A/1446/2019 Masarykova Univerzita

QT interval variability, mostly expressed by QT variability index (QTVi), has repeatedly been used in risk diagnostics. Physiologic correlates of QT variability expressions have been little researched especially when measured in short 10-second electrocardiograms (ECGs). This study investigated different QT variability indices, including QTVi and the standard deviation of QT interval durations (SDQT) in 657,287 10-second ECGs recorded in 523 healthy subjects (259 females). The indices were related to the underlying heart rate and to the 10-second standard deviation of RR intervals (SDRR). The analyses showed that both QTVi and SDQT (as well as other QT variability indices) were highly statistically significantly (p < 0.00001) influenced by heart rate and that QTVi showed poor intra-subject reproducibility (coefficient of variance approaching 200%). Furthermore, sequential analysis of regression variance showed that SDQT was more strongly related to the underlying heart rate than to SDRR, and that QTVi was influenced by the underlying heart rate and SDRR more strongly than by SDQT (p < 0.00001 for these comparisons of regression dependency). The study concludes that instead of QTVi, simpler expressions of QT interval variability, such as SDQT, appear preferable for future applications especially if multivariable combination with the underlying heart rate is used.

Citace poskytuje Crossref.org

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