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Congenital fetal heart defect - an agreement between fetal echocardiography and autopsy findings

J. Pavlicek, Z. Tauber, E. Klaskova, K. Cizkova, M. Prochazka, P. Delongova, B. Stefunko, I. Szotkovska, J. Dvorackova, T. Gruszka

. 2020 ; 164 (1) : 92-99. [pub] 20190923

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21006943

AIMS: To determine the frequency of pregnancy terminations due to prenatal congenital heart defect (CHD) and assess the agreement fetal echocardiography (FECHO) and autopsy findings. METHODS: The data were retrospectively assessed between 2008 and 2017 in a population of 116 698 live births. The correlations between the FECHO and autopsy findings were classified into five levels of agreement: complete, partial, altered diagnosis, disagreement, and unfeasible autopsy. RESULTS: Totally, 293 CHDs were identified and 49% of families (143/293) decided to terminate the pregnancy. In 1% (2/143) of cases, the autopsy could not be performed, for the other 99% (141/143), the pathologist confirmed the presence of CHDs. Complete agreement between FECHO and autopsy was achieved in 85% (122/143). In 10% (14/143) of cases, the pathologist found minor findings, which were not described in the FECHO. In 4% (5/143) of cases, the pathologist changed the main diagnosis. CONCLUSION: Altogether, the results indicated that FECHO is a highly sensitive method for the prenatal detection of CHD but is incapable of detecting the complete spectrum of cardiac defects. Autopsies verified the diagnosis, confirmed the overall impairment in the fetus, and provided data for further counselling of the affected family.

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$a Pavlíček, Jan $7 xx0064568 $u Department of Pediatrics and Prenatal Cardiology, University Hospital Ostrava, Ostrava, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
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$a Congenital fetal heart defect - an agreement between fetal echocardiography and autopsy findings / $c J. Pavlicek, Z. Tauber, E. Klaskova, K. Cizkova, M. Prochazka, P. Delongova, B. Stefunko, I. Szotkovska, J. Dvorackova, T. Gruszka
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$a AIMS: To determine the frequency of pregnancy terminations due to prenatal congenital heart defect (CHD) and assess the agreement fetal echocardiography (FECHO) and autopsy findings. METHODS: The data were retrospectively assessed between 2008 and 2017 in a population of 116 698 live births. The correlations between the FECHO and autopsy findings were classified into five levels of agreement: complete, partial, altered diagnosis, disagreement, and unfeasible autopsy. RESULTS: Totally, 293 CHDs were identified and 49% of families (143/293) decided to terminate the pregnancy. In 1% (2/143) of cases, the autopsy could not be performed, for the other 99% (141/143), the pathologist confirmed the presence of CHDs. Complete agreement between FECHO and autopsy was achieved in 85% (122/143). In 10% (14/143) of cases, the pathologist found minor findings, which were not described in the FECHO. In 4% (5/143) of cases, the pathologist changed the main diagnosis. CONCLUSION: Altogether, the results indicated that FECHO is a highly sensitive method for the prenatal detection of CHD but is incapable of detecting the complete spectrum of cardiac defects. Autopsies verified the diagnosis, confirmed the overall impairment in the fetus, and provided data for further counselling of the affected family.
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$a Tauber, Zdeněk $7 xx0228394 $u Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
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$a Klásková, Eva $7 xx0081724 $u Department of Pediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
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$a Čížková, Kateřina $7 xx0249672 $u Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
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$a Delongová, Patricie $7 xx0259277 $u Department of Pathology, University Hospital Ostrava, Ostrava, Czech Republic
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$a Štefunko, Beáta $7 xx0259259 $u Department of Pathology, University Hospital Ostrava, Ostrava, Czech Republic
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