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Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
Y. Sohrabi, H. Reinecke, R. Godfrey
Trends in endocrinology and metabolism.
2021 ;
32 (3) :
132-134.
[pub] 20210108
Language English Country United States
Document type Journal Article, Comment
Persistent link
https://www.medvik.cz/link/bmc21011477
- MeSH
- Cholesterol MeSH
- COVID-19 * MeSH
- Fructose MeSH
- Humans MeSH
- Lipogenesis * MeSH
- Sterol Regulatory Element Binding Protein 1 metabolism MeSH
- CCAAT-Enhancer-Binding Proteins metabolism MeSH
- SARS-CoV-2 MeSH
- Inflammation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
References provided by Crossref.org
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- $a Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
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