Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic Transmissions

C. Simsek, VM. Corman, HU. Everling, AN. Lukashev, A. Rasche, GD. Maganga, T. Binger, D. Jansen, L. Beller, W. Deboutte, F. Gloza-Rausch, A. Seebens-Hoyer, S. Yordanov, A. Sylverken, S. Oppong, YA. Sarkodie, P. Vallo, EM. Leroy, M. Bourgarel, KC....

. 2021 ; 12 (1) : . [pub] 20210119

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc21011589

Bats host many viruses pathogenic to humans, and increasing evidence suggests that rotavirus A (RVA) also belongs to this list. Rotaviruses cause diarrheal disease in many mammals and birds, and their segmented genomes allow them to reassort and increase their genetic diversity. Eighteen out of 2,142 bat fecal samples (0.8%) collected from Europe, Central America, and Africa were PCR-positive for RVA, and 11 of those were fully characterized using viral metagenomics. Upon contrasting their genomes with publicly available data, at least 7 distinct bat RVA genotype constellations (GCs) were identified, which included evidence of reassortments and 6 novel genotypes. Some of these constellations are spread across the world, whereas others appear to be geographically restricted. Our analyses also suggest that several unusual human and equine RVA strains might be of bat RVA origin, based on their phylogenetic clustering, despite various levels of nucleotide sequence identities between them. Although SA11 is one of the most widely used reference strains for RVA research and forms the backbone of a reverse genetics system, its origin remained enigmatic. Remarkably, the majority of the genotypes of SA11-like strains were shared with Gabonese bat RVAs, suggesting a potential common origin. Overall, our findings suggest an underexplored genetic diversity of RVAs in bats, which is likely only the tip of the iceberg. Increasing contact between humans and bat wildlife will further increase the zoonosis risk, which warrants closer attention to these viruses.IMPORTANCE The increased research on bat coronaviruses after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) allowed the very rapid identification of SARS-CoV-2. This is an excellent example of the importance of knowing viruses harbored by wildlife in general, and bats in particular, for global preparedness against emerging viral pathogens. The current effort to characterize bat rotavirus strains from 3 continents sheds light on the vast genetic diversity of rotaviruses and also hints at a bat origin for several atypical rotaviruses in humans and animals, implying that zoonoses of bat rotaviruses might occur more frequently than currently realized.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21011589
003      
CZ-PrNML
005      
20210507103449.0
007      
ta
008      
210420s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1128/mBio.02755-20 $2 doi
035    __
$a (PubMed)33468689
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Simsek, Ceren $u KU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven, Belgium
245    10
$a At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic Transmissions / $c C. Simsek, VM. Corman, HU. Everling, AN. Lukashev, A. Rasche, GD. Maganga, T. Binger, D. Jansen, L. Beller, W. Deboutte, F. Gloza-Rausch, A. Seebens-Hoyer, S. Yordanov, A. Sylverken, S. Oppong, YA. Sarkodie, P. Vallo, EM. Leroy, M. Bourgarel, KC. Yinda, M. Van Ranst, C. Drosten, JF. Drexler, J. Matthijnssens
520    9_
$a Bats host many viruses pathogenic to humans, and increasing evidence suggests that rotavirus A (RVA) also belongs to this list. Rotaviruses cause diarrheal disease in many mammals and birds, and their segmented genomes allow them to reassort and increase their genetic diversity. Eighteen out of 2,142 bat fecal samples (0.8%) collected from Europe, Central America, and Africa were PCR-positive for RVA, and 11 of those were fully characterized using viral metagenomics. Upon contrasting their genomes with publicly available data, at least 7 distinct bat RVA genotype constellations (GCs) were identified, which included evidence of reassortments and 6 novel genotypes. Some of these constellations are spread across the world, whereas others appear to be geographically restricted. Our analyses also suggest that several unusual human and equine RVA strains might be of bat RVA origin, based on their phylogenetic clustering, despite various levels of nucleotide sequence identities between them. Although SA11 is one of the most widely used reference strains for RVA research and forms the backbone of a reverse genetics system, its origin remained enigmatic. Remarkably, the majority of the genotypes of SA11-like strains were shared with Gabonese bat RVAs, suggesting a potential common origin. Overall, our findings suggest an underexplored genetic diversity of RVAs in bats, which is likely only the tip of the iceberg. Increasing contact between humans and bat wildlife will further increase the zoonosis risk, which warrants closer attention to these viruses.IMPORTANCE The increased research on bat coronaviruses after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) allowed the very rapid identification of SARS-CoV-2. This is an excellent example of the importance of knowing viruses harbored by wildlife in general, and bats in particular, for global preparedness against emerging viral pathogens. The current effort to characterize bat rotavirus strains from 3 continents sheds light on the vast genetic diversity of rotaviruses and also hints at a bat origin for several atypical rotaviruses in humans and animals, implying that zoonoses of bat rotaviruses might occur more frequently than currently realized.
650    _2
$a zvířata $7 D000818
650    _2
$a COVID-19 $x přenos $x virologie $7 D000086382
650    _2
$a Chiroptera $x virologie $7 D002685
650    _2
$a průjem $x virologie $7 D003967
650    _2
$a genetická variace $7 D014644
650    _2
$a genom virový $7 D016679
650    _2
$a genotyp $7 D005838
650    _2
$a koně $7 D006736
650    _2
$a lidé $7 D006801
650    _2
$a metagenomika $7 D056186
650    _2
$a koronavirus MERS $x izolace a purifikace $7 D065207
650    _2
$a fylogeneze $7 D010802
650    _2
$a Rotavirus $x genetika $7 D012401
650    _2
$a rotavirové infekce $x přenos $x virologie $7 D012400
650    _2
$a SARS-CoV-2 $x izolace a purifikace $7 D000086402
650    _2
$a zoonózy $x přenos $x virologie $7 D015047
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Corman, Victor Max $u Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Institute of Virology, Berlin, Germany $u German Centre for Infection Research (DZIF), associated partner Charité Universitätsmedizin Berlin, Berlin, Germany
700    1_
$a Everling, Hermann Ulrich $u Institute of Virology, University of Bonn Medical Centre, Bonn, Germany
700    1_
$a Lukashev, Alexander N $u Sechenov University, Moscow, Russia
700    1_
$a Rasche, Andrea $u Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Institute of Virology, Berlin, Germany $u German Centre for Infection Research (DZIF), associated partner Charité Universitätsmedizin Berlin, Berlin, Germany
700    1_
$a Maganga, Gael Darren $u Centre International de Recherches Médicales de Franceville, Franceville, Gabon $u Université des Sciences et Technique de Masuku, Institut National d'Agronomie et de Biotechnologies, Franceville, Gabon
700    1_
$a Binger, Tabea $u Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana
700    1_
$a Jansen, Daan $u KU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven, Belgium
700    1_
$a Beller, Leen $u KU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven, Belgium
700    1_
$a Deboutte, Ward $u KU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven, Belgium
700    1_
$a Gloza-Rausch, Florian $u Noctalis, Centre for Bat Protection and Information, Bad Segeberg, Germany
700    1_
$a Seebens-Hoyer, Antje $u Noctalis, Centre for Bat Protection and Information, Bad Segeberg, Germany
700    1_
$a Yordanov, Stoian $u Forestry Board Directorate of Strandja Natural Park, Malko Tarnovo, Bulgaria
700    1_
$a Sylverken, Augustina $u Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana $u Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
700    1_
$a Oppong, Samuel $u Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
700    1_
$a Sarkodie, Yaw Adu $u Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
700    1_
$a Vallo, Peter $u Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
700    1_
$a Leroy, Eric M $u Institut de Recherche pour le Développement, UMR 224 (MIVEGEC), IRD/CNRS/Montpellier University, Montpellier, France
700    1_
$a Bourgarel, Mathieu $u CIRAD, UMR ASTRE, Harare, Zimbabwe $u ASTRE, Montpellier University, CIRAD, INRA, Montpellier, France
700    1_
$a Yinda, Kwe Claude $u KU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven, Belgium
700    1_
$a Van Ranst, Marc $u KU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven, Belgium
700    1_
$a Drosten, Christian $u Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Institute of Virology, Berlin, Germany $u German Centre for Infection Research (DZIF), associated partner Charité Universitätsmedizin Berlin, Berlin, Germany
700    1_
$a Drexler, Jan Felix $u Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Institute of Virology, Berlin, Germany Felix.drexler@Charite.de Jelle.matthijnssens@Kuleuven.be $u German Centre for Infection Research (DZIF), associated partner Charité Universitätsmedizin Berlin, Berlin, Germany
700    1_
$a Matthijnssens, Jelle $u KU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Leuven, Belgium Felix.drexler@Charite.de Jelle.matthijnssens@Kuleuven.be
773    0_
$w MED00188129 $t mBio $x 2150-7511 $g Roč. 12, č. 1 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33468689 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20210507103448 $b ABA008
999    __
$a ok $b bmc $g 1650072 $s 1131968
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 12 $c 1 $e 20210119 $i 2150-7511 $m mBio $n MBio $x MED00188129
LZP    __
$a Pubmed-20210420
Back

Find record

Citation metrics

Archiving options