-
Something wrong with this record ?
Rituximab in adult minimal change disease and focal segmental glomerulosclerosis - What is known and what is still unknown
P. Gauckler, JI. Shin, F. Alberici, V. Audard, A. Bruchfeld, M. Busch, CK. Cheung, M. Crnogorac, E. Delbarba, K. Eller, S. Faguer, K. Galesic, S. Griffin, Z. Hrušková, A. Jeyabalan, A. Karras, C. King, HS. Kohli, R. Maas, G. Mayer, S. Moiseev, M....
Language English Country Netherlands
Document type Journal Article, Review
- MeSH
- Adult MeSH
- Glomerulosclerosis, Focal Segmental * drug therapy MeSH
- Immunologic Factors therapeutic use MeSH
- Immunosuppressive Agents adverse effects MeSH
- Humans MeSH
- Nephrosis, Lipoid * drug therapy MeSH
- Nephrotic Syndrome MeSH
- Recurrence MeSH
- Rituximab therapeutic use MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Primary forms of minimal change disease and focal segmental glomerulosclerosis are rare podocytopathies and clinically characterized by nephrotic syndrome. Glucocorticoids are the cornerstone of the initial immunosuppressive treatment in these two entities. Especially among adults with minimal change disease or focal segmental glomerulosclerosis, relapses, steroid dependence or resistance are common and necessitate re-initiation of steroids and other immunosuppressants. Effective steroid-sparing therapies and introduction of less toxic immunosuppressive agents are urgently needed to reduce undesirable side effects, in particular for patients whose disease course is complex. Rituximab, a B cell depleting monoclonal antibody, is increasingly used off-label in these circumstances, despite a low level of evidence for adult patients. Hence, critical questions concerning drug-safety, long-term efficacy and the optimal regimen for rituximab-treatment remain unanswered. Evidence in the form of large, multicenter studies and randomized controlled trials are urgently needed to overcome these limitations.
Department of Cardiovascular Sciences University of Leicester Leicester United Kingdom
Department of Health Medicine and Caring Sciences Linköping University Linköping Sweden
Department of Internal Medicine 4 Section of Nephrology Klinikum Wels Grieskirchen Wels Austria
Department of Nephrology and Transplantation University Hospital of Wales Cardiff UK
Department of Nephrology Juntendo University Faculty of Medicine Tokyo Japan
Department of Nephrology Radboud University Medical Center PO Box 9101 6500 HB Nijmegen Netherlands
Department of Nephrology University of Brescia Hospital of Montichiari Brescia Italy
Department of Pediatrics Yonsei University College of Medicine Seoul 03722 Republic of Korea
Division of Nephrology and Hypertension Mayo Clinic Rochester MN USA
Division of Nephrology Columbia University Medical Center NY New York USA
Division of Pediatric Nephrology Severance Children's Hospital Seoul 03722 Republic of Korea
Institut National de la Santé et de la Recherche Médicale U1048 31000 Toulouse France
John Walls Renal Unit University Hospitals of Leicester NHS Trust Leicester United Kingdom
Medical Faculty Johannes Kepler University Linz Altenberger Strasse 69 4040 Linz Austria
Nephrology Post Graduate Institute of Medical Education and Research Chandigarh India
Nephrology Unit ASST Spedali Civili di Brescia Brescia Italy
Tareev Clinic of Internal Diseases Sechenov 1st Moscow State Medical University Moscow Russia
University College London Department of Renal Medicine Royal Free Hospital London UK
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21011910
- 003
- CZ-PrNML
- 005
- 20210507101612.0
- 007
- ta
- 008
- 210420s2020 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.autrev.2020.102671 $2 doi
- 035 __
- $a (PubMed)32942039
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Gauckler, Philipp $u Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Electronic address: philipp.gauckler@i-med.ac.at
- 245 10
- $a Rituximab in adult minimal change disease and focal segmental glomerulosclerosis - What is known and what is still unknown / $c P. Gauckler, JI. Shin, F. Alberici, V. Audard, A. Bruchfeld, M. Busch, CK. Cheung, M. Crnogorac, E. Delbarba, K. Eller, S. Faguer, K. Galesic, S. Griffin, Z. Hrušková, A. Jeyabalan, A. Karras, C. King, HS. Kohli, R. Maas, G. Mayer, S. Moiseev, M. Muto, B. Odler, RJ. Pepper, LF. Quintana, J. Radhakrishnan, R. Ramachandran, AD. Salama, M. Segelmark, V. Tesař, J. Wetzels, L. Willcocks, M. Windpessl, L. Zand, R. Zonozi, A. Kronbichler, RITERM study group
- 520 9_
- $a Primary forms of minimal change disease and focal segmental glomerulosclerosis are rare podocytopathies and clinically characterized by nephrotic syndrome. Glucocorticoids are the cornerstone of the initial immunosuppressive treatment in these two entities. Especially among adults with minimal change disease or focal segmental glomerulosclerosis, relapses, steroid dependence or resistance are common and necessitate re-initiation of steroids and other immunosuppressants. Effective steroid-sparing therapies and introduction of less toxic immunosuppressive agents are urgently needed to reduce undesirable side effects, in particular for patients whose disease course is complex. Rituximab, a B cell depleting monoclonal antibody, is increasingly used off-label in these circumstances, despite a low level of evidence for adult patients. Hence, critical questions concerning drug-safety, long-term efficacy and the optimal regimen for rituximab-treatment remain unanswered. Evidence in the form of large, multicenter studies and randomized controlled trials are urgently needed to overcome these limitations.
- 650 _2
- $a dospělí $7 D000328
- 650 12
- $a fokálně segmentální glomeruloskleróza $x farmakoterapie $7 D005923
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunologické faktory $x terapeutické užití $7 D007155
- 650 _2
- $a imunosupresiva $x škodlivé účinky $7 D007166
- 650 12
- $a lipoidní nefróza $x farmakoterapie $7 D009402
- 650 _2
- $a nefrotický syndrom $7 D009404
- 650 _2
- $a recidiva $7 D012008
- 650 _2
- $a rituximab $x terapeutické užití $7 D000069283
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Shin, Jae Il $u Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; Division of Pediatric Nephrology, Severance Children's Hospital, Seoul 03722, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
- 700 1_
- $a Alberici, Federico $u Nephrology Unit, ASST Spedali Civili di Brescia, Brescia, Italy; Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy
- 700 1_
- $a Audard, Vincent $u Department of Nephrology and Transplantation, Rare French Disease Centre "Idiopathic Nephrotic syndrome", Henri-Mondor/Albert-Chenevier Hospital Assistance Publique-Hôpitaux de Paris, Inserm U955, Team 21, Paris-East University, 94000 Créteil, France
- 700 1_
- $a Bruchfeld, Annette $u Department of Renal Medicine, CLINTEC, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
- 700 1_
- $a Busch, Martin $u Department of Internal Medicine III, University Hospital Jena, Friedrich-Schiller-University, Jena, Germany
- 700 1_
- $a Cheung, Chee Kay $u Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; John Walls Renal Unit, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
- 700 1_
- $a Crnogorac, Matija $u Department of Nephrology and Dialysis, Dubrava University Hospital, Avenija Gojka Suska 6, 10 000 Zagreb, Croatia
- 700 1_
- $a Delbarba, Elisa $u Department of Nephrology, University of Brescia, Hospital of Montichiari, Brescia, Italy
- 700 1_
- $a Eller, Kathrin $u Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
- 700 1_
- $a Faguer, Stanislas $u Département de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France; Institut National de la Santé et de la Recherche Médicale, U1048 (Institut des Maladies Cardiovasculaires et Métaboliques-équipe 12), 31000 Toulouse, France
- 700 1_
- $a Galesic, Kresimir $u Department of Nephrology and Dialysis, Dubrava University Hospital, Avenija Gojka Suska 6, 10 000 Zagreb, Croatia
- 700 1_
- $a Griffin, Siân $u Department of Nephrology and Transplantation, University Hospital of Wales, Cardiff, UK
- 700 1_
- $a Hrušková, Zdenka $u Department of Nephrology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
- 700 1_
- $a Jeyabalan, Anushya $u Division of Nephrology, Columbia University Medical Center, NY, New York, USA
- 700 1_
- $a Karras, Alexandre $u Service de Néphrologie, Hôpital Européen-Georges Pompidou, Assistance Publique des Hôpitaux de Paris, 75015 Paris, France
- 700 1_
- $a King, Catherine $u Centre for Translational Inflammation Research University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK
- 700 1_
- $a Kohli, Harbir Singh $u Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- 700 1_
- $a Maas, Rutger $u Department of Nephrology, Radboud University Medical Center, PO Box 9101, 6500, HB, Nijmegen, Netherlands
- 700 1_
- $a Mayer, Gert $u Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
- 700 1_
- $a Moiseev, Sergey $u Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia
- 700 1_
- $a Muto, Masahiro $u Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan
- 700 1_
- $a Odler, Balazs $u Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
- 700 1_
- $a Pepper, Ruth J $u University College London Department of Renal Medicine, Royal Free Hospital, London, UK
- 700 1_
- $a Quintana, Luis F $u Department of Nephrology and Renal Transplantation, Hospital Clínic, Centro de Referencia en Enfermedad Glomerular Compleja del Sistema Nacional de Salud (CSUR), Department of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
- 700 1_
- $a Radhakrishnan, Jai $u Division of Nephrology, Columbia University Medical Center, NY, New York, USA
- 700 1_
- $a Ramachandran, Raja $u Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- 700 1_
- $a Salama, Alan D $u University College London Department of Renal Medicine, Royal Free Hospital, London, UK
- 700 1_
- $a Segelmark, Mårten $u Department of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden
- 700 1_
- $a Tesař, Vladimír $u Department of Nephrology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
- 700 1_
- $a Wetzels, Jack $u Department of Nephrology, Radboud University Medical Center, PO Box 9101, 6500, HB, Nijmegen, Netherlands
- 700 1_
- $a Willcocks, Lisa $u Department of Renal Medicine, Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK
- 700 1_
- $a Windpessl, Martin $u Department of Internal Medicine IV, Section of Nephrology, Klinikum Wels-Grieskirchen, Wels, Austria; Medical Faculty, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria
- 700 1_
- $a Zand, Ladan $u Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
- 700 1_
- $a Zonozi, Reza $u Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, 101 Merrimac Street, Boston, MA 02114, USA
- 700 1_
- $a Kronbichler, Andreas $u Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Electronic address: andreas.kronbichler@i-med.ac.at
- 710 2_
- $a RITERM study group
- 773 0_
- $w MED00008572 $t Autoimmunity reviews $x 1873-0183 $g Roč. 19, č. 11 (2020), s. 102671
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32942039 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210420 $b ABA008
- 991 __
- $a 20210507101612 $b ABA008
- 999 __
- $a ok $b bmc $g 1650313 $s 1132289
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 19 $c 11 $d 102671 $e 20200915 $i 1873-0183 $m Autoimmunity reviews $n Autoimmun Rev $x MED00008572
- LZP __
- $a Pubmed-20210420
