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(Mammary Analogue) Secretory Carcinoma of the Nasal Cavity: Report of a Rare Case with p63 and DOG1 Expression and Uncommon Exon 4-Exon 14 ETV6-NTRK3 Fusion Diagnosed with Next Generation Sequencing
B. Wu, TKS. Loh, T. Vanecek, M. Michal, F. Petersson
Language English Country United States
Document type Case Reports, Journal Article
NLK
PubMed Central
from 2007 to 1 year ago
Europe PubMed Central
from 2007 to 1 year ago
- MeSH
- Anoctamin-1 biosynthesis MeSH
- Exons genetics MeSH
- Oncogene Proteins, Fusion genetics MeSH
- Humans MeSH
- Membrane Proteins biosynthesis MeSH
- Biomarkers, Tumor analysis MeSH
- Neoplasm Proteins biosynthesis MeSH
- Nose Neoplasms genetics pathology MeSH
- Nasal Cavity pathology MeSH
- Mammary Analogue Secretory Carcinoma genetics pathology MeSH
- Sequence Analysis, DNA MeSH
- Aged MeSH
- High-Throughput Nucleotide Sequencing MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
We present a 72 years old male with a left nasal cavity (mammary analogue) secretory carcinoma (SC) which exhibited classical morphological features on light microscopical examination, diffuse strong S100 and mammoglobin positivity on immunohistochemistry, and ETV6-NTRK3 gene fusion on next generation sequencing (NGS) analysis. Unusual features of this tumor are expression of p63 and DOG1 on immunohistochemistry and the atypical junction between Exon 4 of the ETV6 gene and Exon 14 of the NTRK3 gene.
Department of Otolaryngology National University Health System Singapore Singapore
Department of Pathology Faculty of Medicine in Plzen Charles University Plzen Czech Republic
Molecular and Genetic Laboratory Biopticka Laboratory Ltd Plzen Czech Republic
References provided by Crossref.org
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- $a We present a 72 years old male with a left nasal cavity (mammary analogue) secretory carcinoma (SC) which exhibited classical morphological features on light microscopical examination, diffuse strong S100 and mammoglobin positivity on immunohistochemistry, and ETV6-NTRK3 gene fusion on next generation sequencing (NGS) analysis. Unusual features of this tumor are expression of p63 and DOG1 on immunohistochemistry and the atypical junction between Exon 4 of the ETV6 gene and Exon 14 of the NTRK3 gene.
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