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Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family
D. Koutová, N. Maafi, R. Havelek, L. Opletal, G. Blunden, M. Řezáčová, L. Cahlíková
Language English Country Switzerland
Document type Journal Article, Review
Grant support
SVV UK 260 548; Progres/UK Q40-01 and Q42
Univerzita Karlova v Praze
CZ.02.1.01/0.0/0.0/18_069/0010046
European Union
NLK
Directory of Open Access Journals
from 1997
Free Medical Journals
from 1997
PubMed Central
from 2001
Europe PubMed Central
from 2001
ProQuest Central
from 1997-01-01
Open Access Digital Library
from 1997-01-01
Medline Complete (EBSCOhost)
from 2009-03-01
Health & Medicine (ProQuest)
from 1997-01-01
- MeSH
- Amaryllidaceae Alkaloids chemistry isolation & purification pharmacology MeSH
- Amaryllidaceae chemistry metabolism MeSH
- Antiprotozoal Agents chemistry isolation & purification pharmacology MeSH
- Cholinesterase Inhibitors chemistry isolation & purification pharmacology MeSH
- Phenanthridines chemistry isolation & purification pharmacology MeSH
- Antineoplastic Agents, Phytogenic chemistry isolation & purification pharmacology MeSH
- Galantamine chemistry isolation & purification pharmacology MeSH
- Heterocyclic Compounds, 4 or More Rings chemistry isolation & purification pharmacology MeSH
- Inhibitory Concentration 50 MeSH
- Isoquinolines chemistry isolation & purification pharmacology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Nootropic Agents chemistry isolation & purification pharmacology MeSH
- Plant Extracts chemistry MeSH
- Secondary Metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Plants of the Amaryllidaceae family are promising therapeutic tools for human diseases and have been used as alternative medicines. The specific secondary metabolites of this plant family, called Amaryllidaceae alkaloids (AA), have attracted considerable attention due to their interesting pharmacological activities. One of them, galantamine, is already used in the therapy of Alzheimer's disease as a long acting, selective, reversible inhibitor of acetylcholinesterase. One group of AA is the montanine-type, such as montanine, pancracine and others, which share a 5,11-methanomorphanthridine core. So far, only 14 montanine-type alkaloids have been isolated. Compared with other structural-types of AA, montanine-type alkaloids are predominantly present in plants in low concentrations, but some of them display promising biological properties, especially in vitro cytotoxic activity against different cancerous cell lines. The present review aims to summarize comprehensively the research that has been published on the Amaryllidaceae alkaloids of montanine-type.
References provided by Crossref.org
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- $a Plants of the Amaryllidaceae family are promising therapeutic tools for human diseases and have been used as alternative medicines. The specific secondary metabolites of this plant family, called Amaryllidaceae alkaloids (AA), have attracted considerable attention due to their interesting pharmacological activities. One of them, galantamine, is already used in the therapy of Alzheimer's disease as a long acting, selective, reversible inhibitor of acetylcholinesterase. One group of AA is the montanine-type, such as montanine, pancracine and others, which share a 5,11-methanomorphanthridine core. So far, only 14 montanine-type alkaloids have been isolated. Compared with other structural-types of AA, montanine-type alkaloids are predominantly present in plants in low concentrations, but some of them display promising biological properties, especially in vitro cytotoxic activity against different cancerous cell lines. The present review aims to summarize comprehensively the research that has been published on the Amaryllidaceae alkaloids of montanine-type.
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