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Oxidative Stress in Autism Spectrum Disorder
G. Bjørklund, NA. Meguid, MA. El-Bana, AA. Tinkov, K. Saad, M. Dadar, M. Hemimi, AV. Skalny, B. Hosnedlová, R. Kizek, J. Osredkar, MA. Urbina, T. Fabjan, AA. El-Houfey, J. Kałużna-Czaplińska, P. Gątarek, S. Chirumbolo
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 1997-02-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2010-02-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-02-01 do Před 1 rokem
Psychology Database (ProQuest)
od 1997-02-01 do Před 1 rokem
- MeSH
- aerobióza MeSH
- antioxidancia metabolismus MeSH
- centrální nervový systém metabolismus MeSH
- dítě MeSH
- dysbióza komplikace MeSH
- gastrointestinální nemoci komplikace MeSH
- glutathionperoxidasa metabolismus MeSH
- incidence MeSH
- lidé MeSH
- metalothionein metabolismus MeSH
- mitochondrie metabolismus MeSH
- mozek - chemie MeSH
- neurodegenerativní nemoci etiologie metabolismus MeSH
- oxidace-redukce MeSH
- oxidační stres * MeSH
- peroxidace lipidů MeSH
- poruchy autistického spektra epidemiologie imunologie metabolismus patofyziologie MeSH
- předškolní dítě MeSH
- scavengery volných radikálů metabolismus MeSH
- selen fyziologie MeSH
- selenoproteiny metabolismus MeSH
- střevní mikroflóra MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with an autism spectrum disorder (ASD) was 1 in 68 (1.46%) among 8-year-old children born in 2004 and living within the 11 monitoring sites' surveillance areas in the United States of America (USA) in 2012. ASD is a multifaceted neurodevelopmental disorder that is also considered a hidden disability, as, for the most part; there are no apparent morphological differences between children with ASD and typically developing children. ASD is diagnosed based upon a triad of features including impairment in socialization, impairment in language, and repetitive and stereotypic behaviors. The increasing incidence of ASD in the pediatric population and the lack of successful curative therapies make ASD one of the most challenging disorders for medicine. ASD neurobiology is thought to be associated with oxidative stress, as shown by increased levels of reactive oxygen species and increased lipid peroxidation, as well as an increase in other indicators of oxidative stress. Children with ASD diagnosis are considered more vulnerable to oxidative stress because of their imbalance in intracellular and extracellular glutathione levels and decreased glutathione reserve capacity. Several studies have suggested that the redox imbalance and oxidative stress are integral parts of ASD pathophysiology. As such, early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage. In this review, many aspects of the role of oxidative stress in ASD are discussed, taking into account that the process of oxidative stress may be a target for therapeutic interventions.
CONEM Egypt Child Brain Research Group National Research Center Giza Egypt
CONEM Metallomics Nanomedicine Research Group Brno Czech Republic
CONEM Poland Chemistry and Nutrition Research Group Lodz University of Technology Lodz Poland
CONEM Scientific Secretary Verona Italy
CONEM Upper Egypt Pediatric Research Group Assiut University Assiut Egypt
Council for Nutritional and Environmental Medicine Toften 24 8610 Mo i Rana Norway
Department of Community Health Nursing Faculty of Nursing Assiut University Assiut Egypt
Department of Community Health Nursing Sabia University College Jazan University Jizan Saudi Arabia
Department of Neurological and Movement Sciences University of Verona Verona Italy
Department of Pediatrics Faculty of Medicine Assiut University Assiut Egypt
IM Sechenov 1st Moscow State Medical University Moscow Russia
Medical Biochemistry Department National Research Centre Giza Egypt
Peoples' Friendship University of Russia Moscow Russia
Research on Children with Special Needs Department National Research Centre Giza Egypt
Citace poskytuje Crossref.org
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