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Rituximab in Membranous Nephropathy
P. Gauckler, JI. Shin, F. Alberici, V. Audard, A. Bruchfeld, M. Busch, CK. Cheung, M. Crnogorac, E. Delbarba, K. Eller, S. Faguer, K. Galesic, S. Griffin, MWF. van den Hoogen, Z. Hrušková, A. Jeyabalan, A. Karras, C. King, HS. Kohli, G. Mayer, R....
Language English Country United States
Document type Journal Article, Review
NLK
Directory of Open Access Journals
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PubMed Central
from 2016
Europe PubMed Central
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ROAD: Directory of Open Access Scholarly Resources
from 2016
- Publication type
- Journal Article MeSH
- Review MeSH
Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has been investigated in several studies, including 3 randomized controlled trials, in which complete and partial remission of proteinuria was achieved in approximately two-thirds of treated patients. Due to its favorable safety profile, rituximab is now considered a first-line treatment option for MN, especially in patients at moderate and high risk of deterioration in kidney function. However, questions remain about how to best use rituximab, including the optimal dosing regimen, a potential need for maintenance therapy, and assessment of long-term safety and efficacy outcomes. In this review, we provide an overview of the current literature and discuss both strengths and limitations of "the new standard."
Department of Cardiovascular Sciences University of Leicester Leicester United Kingdom
Department of Health Medicine and Caring Sciences Linköping University Linköping Sweden
Department of Internal Medicine 4 Medical University Innsbruck Innsbruck Austria
Department of Internal Medicine 4 Section of Nephrology Klinikum Wels Grieskirchen Wels Austria
Department of Internal Medicine Erasmus MC University Medical Centre Rotterdam Rotterdam Netherlands
Department of Nephrology and Dialysis Dubrava University Hospital Zagreb Croatia
Department of Nephrology and Transplantation University Hospital of Wales Cardiff UK
Department of Nephrology Juntendo University Faculty of Medicine Tokyo Japan
Department of Nephrology Radboud University Medical Center Nijmegen Netherlands
Department of Pediatrics Yonsei University College of Medicine Seoul Korea
Division of Nephrology and Hypertension Mayo Clinic Rochester Minnesota USA
Division of Nephrology Columbia University Medical Center New York New York USA
Division of Nephrology Department of Medicine 4 University Hospital LMU Munich Munich Germany
Division of Pediatric Nephrology Severance Children's Hospital Seoul Korea
Institut National de la Santé et de la Recherche Médicale U1048 Toulouse France
Institute of Kidney Disease Research Yonsei University College of Medicine Seoul Korea
John Walls Renal Unit University Hospitals of Leicester NHS Trust Leicester UK
Medical Faculty Johannes Kepler University Linz Linz Austria
Nephrology Post Graduate Institute of Medical Education and Research Chandigarh India
Nephrology Unit ASST Spedali Civili di Brescia Brescia Italy
Tareev Clinic of Internal Diseases Sechenov 1st Moscow State Medical University Moscow Russia
The Cambridge Centre for Sport and Exercise Science Anglia Ruskin University Cambridge UK
University College London Department of Renal Medicine Royal Free Hospital London UK
References provided by Crossref.org
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