-
Je něco špatně v tomto záznamu ?
Hyaluronan and its derivatives for ophthalmology: Recent advances and future perspectives
G. Huerta Ángeles, K. Nešporová
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, přehledy
- MeSH
- glaukom farmakoterapie MeSH
- kyselina hyaluronová analogy a deriváty terapeutické užití MeSH
- lidé MeSH
- nosiče léků chemie MeSH
- oční nemoci farmakoterapie MeSH
- oční roztoky chemie MeSH
- protinádorové látky chemie metabolismus MeSH
- viskozita MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Ophthalmic disorders are amid the most common pathologies worldwide. In this regard, hyaluronan (HA) has gained widespread use in eye surgeries and treatment of eye diseases. HA-based materials are well tolerated and show excellent biocompatibility. Therefore, HA is a sought-after component of ophthalmic formulations. However, several parameters have to be adjusted to reach an optimal performance and effectiveness. The complexity of HA properties represents a major challenge for biological and structural characterization. This review covers fundamental aspects and recent developments in HA ophthalmic research. Biological mechanisms underlying the health benefits of HA and their potential therapeutic applications are elaborated. Furthermore, current pharmacokinetic and safety studies are discussed. Noticeably, the benefits of chemical modification and processed HA forms are described to broaden the applications of this unique polysaccharide. The current research challenges and prospects are also outlined and discussed.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21018670
- 003
- CZ-PrNML
- 005
- 20210830100246.0
- 007
- ta
- 008
- 210728s2021 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.carbpol.2021.117697 $2 doi
- 035 __
- $a (PubMed)33673986
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Huerta Ángeles, Gloria $u Contipro a.s, Dolní Dobrouč 401, 561 02, Dolnί Dobrouč, Czech Republic. Electronic address: huerta-angeles@contipro.com
- 245 10
- $a Hyaluronan and its derivatives for ophthalmology: Recent advances and future perspectives / $c G. Huerta Ángeles, K. Nešporová
- 520 9_
- $a Ophthalmic disorders are amid the most common pathologies worldwide. In this regard, hyaluronan (HA) has gained widespread use in eye surgeries and treatment of eye diseases. HA-based materials are well tolerated and show excellent biocompatibility. Therefore, HA is a sought-after component of ophthalmic formulations. However, several parameters have to be adjusted to reach an optimal performance and effectiveness. The complexity of HA properties represents a major challenge for biological and structural characterization. This review covers fundamental aspects and recent developments in HA ophthalmic research. Biological mechanisms underlying the health benefits of HA and their potential therapeutic applications are elaborated. Furthermore, current pharmacokinetic and safety studies are discussed. Noticeably, the benefits of chemical modification and processed HA forms are described to broaden the applications of this unique polysaccharide. The current research challenges and prospects are also outlined and discussed.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a protinádorové látky $x chemie $x metabolismus $7 D000970
- 650 _2
- $a nosiče léků $x chemie $7 D004337
- 650 _2
- $a oční nemoci $x farmakoterapie $7 D005128
- 650 _2
- $a glaukom $x farmakoterapie $7 D005901
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kyselina hyaluronová $x analogy a deriváty $x terapeutické užití $7 D006820
- 650 _2
- $a oční roztoky $x chemie $7 D009883
- 650 _2
- $a viskozita $7 D014783
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Nešporová, Kristina $u Contipro a.s, Dolní Dobrouč 401, 561 02, Dolnί Dobrouč, Czech Republic
- 773 0_
- $w MED00006149 $t Carbohydrate polymers $x 1879-1344 $g Roč. 259, č. - (2021), s. 117697
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33673986 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210728 $b ABA008
- 991 __
- $a 20210830100246 $b ABA008
- 999 __
- $a ok $b bmc $g 1689692 $s 1139116
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 259 $c - $d 117697 $e 20210126 $i 1879-1344 $m Carbohydrate polymers $n Carbohydr Polym $x MED00006149
- LZP __
- $a Pubmed-20210728
