Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Anti-asthma Drugs Formoterol and Budesonide (Symbicort) Induce Orofacial Clefts, Gastroschisis and Heart Septum Defects in an In Vivo Model

M. Peterka, LH. Heringova, A. Sukop, R. Peterkova

. 2021 ; 35 (3) : 1451-1460. [pub] -

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21018692

BACKGROUND: We had a case in which three consecutive pregnancies resulted in birth of three children with an orofacial cleft. Their mother suffered from bronchial asthma and was treated using symbicort (corticosteroid budesonide plus bronchodilator formoterol) during her pregnancies. A hypothesis was assessed: these anti-asthmatics can induce an orofacial cleft in experimental model. MATERIALS AND METHODS: A single administration of one of five increasing doses (including therapeutically used ones) of Symbicort, budesonide or formoterol was injected into the amnion of a chick embryo on day 4 or 5 of incubation. The teratogenic/lethal effects of the anti-asthmatics were assessed on a total of 600 embryos. RESULTS: For budesonide, the teratogenic/lethal effect started at a dose 0.003 μg per embryo, for formoterol at 0.3 μg and for Symbicort 0.03 μg. Orofacial clefts and gastroschisis after exposure were found for all three anti-asthmatics. Heart septum defects occurred after exposure to formoterol. CONCLUSION: The present results support those clinical/epidemiological studies pointing out that anti-asthmatics have the potential to induce orofacial clefts, gastroschisis and heart malformations during prenatal development in human.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21018692
003      
CZ-PrNML
005      
20210830100256.0
007      
ta
008      
210728s2021 gr f 000 0|eng||
009      
AR
024    7_
$a 10.21873/invivo.12397 $2 doi
035    __
$a (PubMed)33910822
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gr
100    1_
$a Peterka, Miroslav $u Cleft Centre, Clinic of Plastic Surgery, Kralovske Vinohrady University Hospital and Third Faculty of Medicine, Charles University, Prague, Czech Republic; peterkamm@seznam.cz $u Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic
245    10
$a Anti-asthma Drugs Formoterol and Budesonide (Symbicort) Induce Orofacial Clefts, Gastroschisis and Heart Septum Defects in an In Vivo Model / $c M. Peterka, LH. Heringova, A. Sukop, R. Peterkova
520    9_
$a BACKGROUND: We had a case in which three consecutive pregnancies resulted in birth of three children with an orofacial cleft. Their mother suffered from bronchial asthma and was treated using symbicort (corticosteroid budesonide plus bronchodilator formoterol) during her pregnancies. A hypothesis was assessed: these anti-asthmatics can induce an orofacial cleft in experimental model. MATERIALS AND METHODS: A single administration of one of five increasing doses (including therapeutically used ones) of Symbicort, budesonide or formoterol was injected into the amnion of a chick embryo on day 4 or 5 of incubation. The teratogenic/lethal effects of the anti-asthmatics were assessed on a total of 600 embryos. RESULTS: For budesonide, the teratogenic/lethal effect started at a dose 0.003 μg per embryo, for formoterol at 0.3 μg and for Symbicort 0.03 μg. Orofacial clefts and gastroschisis after exposure were found for all three anti-asthmatics. Heart septum defects occurred after exposure to formoterol. CONCLUSION: The present results support those clinical/epidemiological studies pointing out that anti-asthmatics have the potential to induce orofacial clefts, gastroschisis and heart malformations during prenatal development in human.
650    _2
$a aplikace inhalační $7 D000280
650    _2
$a zvířata $7 D000818
650    12
$a antiastmatika $7 D018927
650    _2
$a budesonid $x škodlivé účinky $7 D019819
650    _2
$a kombinace léků budesonid a formoterol $7 D000069502
650    _2
$a kuřecí embryo $7 D002642
650    _2
$a dítě $7 D002648
650    12
$a rozštěp rtu $x chemicky indukované $7 D002971
650    12
$a rozštěp patra $x chemicky indukované $7 D002972
650    _2
$a dvojitá slepá metoda $7 D004311
650    _2
$a ethanolaminy $x škodlivé účinky $7 D004983
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a formoterol fumarát $x škodlivé účinky $7 D000068759
650    12
$a gastroschiza $x chemicky indukované $7 D020139
650    _2
$a srdeční septum $7 D006346
650    _2
$a lidé $7 D006801
650    _2
$a výsledek terapie $7 D016896
655    _2
$a časopisecké články $7 D016428
700    1_
$a Heringova, Lucie Hubickova $u Institute of Histology and Embryology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Sukop, Andrej $u Cleft Centre, Clinic of Plastic Surgery, Kralovske Vinohrady University Hospital and Third Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Peterkova, Renata $u Institute of Histology and Embryology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
773    0_
$w MED00175831 $t In vivo (Athens, Greece) $x 1791-7549 $g Roč. 35, č. 3 (2021), s. 1451-1460
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33910822 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830100256 $b ABA008
999    __
$a ok $b bmc $g 1689708 $s 1139138
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 35 $c 3 $d 1451-1460 $e - $i 1791-7549 $m In Vivo $n In Vivo $x MED00175831
LZP    __
$a Pubmed-20210728

Najít záznam

Citační ukazatele

Možnosti archivace