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Diagnostic approach in TFE3-rearranged renal cell carcinoma: a multi-institutional international survey
M. Akgul, SR. Williamson, D. Ertoy, P. Argani, S. Gupta, A. Caliò, V. Reuter, S. Tickoo, HA. Al-Ahmadie, GJ. Netto, O. Hes, MS. Hirsch, B. Delahunt, R. Mehra, S. Skala, AO. Osunkoya, L. Harik, P. Rao, AR. Sangoi, M. Nourieh, DL. Zynger, SC....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
NLK
ProQuest Central
od 2000-01-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 2000-01-01 do Před 6 měsíci
- MeSH
- dítě MeSH
- dospělí MeSH
- fenotyp MeSH
- genetická predispozice k nemoci MeSH
- genová přestavba * MeSH
- hybridizace in situ fluorescenční * MeSH
- imunohistochemie * MeSH
- karcinom z renálních buněk chemie diagnóza genetika patologie MeSH
- kojenec MeSH
- lékařská praxe - způsoby provádění MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádorové biomarkery genetika MeSH
- nádory ledvin chemie diagnóza genetika patologie MeSH
- patologové MeSH
- prediktivní hodnota testů MeSH
- předškolní dítě MeSH
- průzkumy zdravotní péče MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- transkripční faktory BHLH-Zip genetika MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Transcription factor E3-rearranged renal cell carcinoma (TFE3-RCC) has heterogenous morphologic and immunohistochemical (IHC) features.131 pathologists with genitourinary expertise were invited in an online survey containing 23 questions assessing their experience on TFE3-RCC diagnostic work-up.Fifty (38%) participants completed the survey. 46 of 50 participants reported multiple patterns, most commonly papillary pattern (almost always 9/46, 19.5%; frequently 29/46, 63%). Large epithelioid cells with abundant cytoplasm were the most encountered cytologic feature, with either clear (almost always 10/50, 20%; frequently 34/50, 68%) or eosinophilic (almost always 4/49, 8%; frequently 28/49, 57%) cytology. Strong (3+) or diffuse (>75% of tumour cells) nuclear TFE3 IHC expression was considered diagnostic by 13/46 (28%) and 12/47 (26%) participants, respectively. Main TFE3 IHC issues were the low specificity (16/42, 38%), unreliable staining performance (15/42, 36%) and background staining (12/42, 29%). Most preferred IHC assays other than TFE3, cathepsin K and pancytokeratin were melan A (44/50, 88%), HMB45 (43/50, 86%), carbonic anhydrase IX (41/50, 82%) and CK7 (32/50, 64%). Cut-off for positive TFE3 fluorescent in situ hybridisation (FISH) was preferably 10% (9/50, 18%), although significant variation in cut-off values was present. 23/48 (48%) participants required TFE3 FISH testing to confirm TFE3-RCC regardless of the histomorphologic and IHC assessment. 28/50 (56%) participants would request additional molecular studies other than FISH assay in selected cases, whereas 3/50 participants use additional molecular cases in all cases when TFE3-RCC is in the differential.Optimal diagnostic approach on TFE3-RCC is impacted by IHC and/or FISH assay preferences as well as their conflicting interpretation methods.
Aquesta Pathology Brisbane Queensland Australia
Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA
Department of Pathology and Surgery Cordoba University Medical School Cordoba Spain
Department of Pathology Charleston Area Medical Center Charleston South Carolina USA
Department of Pathology El Camino Hospital Mountain View California USA
Department of Pathology Emory University School of Medicine Atlanta Georgia USA
Department of Pathology Hartford Hospital Hartford Connecticut USA
Department of Pathology Houston Methodist Hospital Houston Texas USA
Department of Pathology Institut Curie Paris France
Department of Pathology Karolinska Institute Stockholm Sweden
Department of Pathology Koc University School of Medicine Istanbul Turkey
Department of Pathology Loyola University Health System Maywood Illinois USA
Department of Pathology Mayo Clinic Rochester Minnesota USA
Department of Pathology Memorial Sloan Kettering Cancer Center New York City New York USA
Department of Pathology Mount Auburn Hospital Cambridge Massachusetts USA
Department of Pathology New York University Langone Medical Center New York City New York USA
Department of Pathology St Joseph Mercy Hospital Ann Arbor Michigan USA
Department of Pathology St Luke's Hospital Manila Philippines
Department of Pathology The Johns Hopkins Hospital Baltimore Maryland USA
Department of Pathology The Ohio State University Medical Center Columbus Ohio USA
Department of Pathology Univer Irvine Healthcare Orange County California USA
Department of Pathology University of Alabama at Birmingham Birmingham Alabama USA
Department of Pathology University of Louisville Louisville Kentucky USA
Department of Pathology University of Michigan Ann Arbor Michigan USA
Department of Pathology University of North Carolina System Chapel Hill North Carolina USA
Department of Pathology University of Texas MD Anderson Cancer Center Houston Texas USA
Department of Pathology University of Washington Seattle Washington USA
Department of Pathology Virginia Commonwealth University School of Medicine Richmond Virginia USA
Department of Pathology Yildirim Beyazit University School of Medicine Ankara Turkey
Faculty of Medicine in Plzen Charles University Plzen Czech Republic
Forward Pathology Solutions Vanderbilt University Kansas City Montana USA
IHA Pathology and Laboratory Medicine Ann Arbor Michigan USA
Medical Teaching School University Hospital Charles University Plzen Czech Republic
Pathology Albany Medical Center Albany New York USA
Pathology Memorial Sloan Kettering Cancer Center New York City New York USA
Pathology University Hospital Center of Martinique Fort de France Martinique
Robert J Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic Cleveland Ohio USA
Citace poskytuje Crossref.org
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