Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters

I. Vojtechova, K. Maleninska, V. Kutna, O. Klovrza, K. Tuckova, T. Petrasek, A. Stuchlik

. 2021 ; 22 (6) : . [pub] 20210323

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019014

Grantová podpora
19-03016S Czech Science Foundation (GACR)
17-30833A Czech Health Research Council (AZV)
172515 Grant agency of the Charles University (GA UK)
National Institute of Mental Health - NIMH, IN: 00023752 MH CZ - DRO
LO1611 Ministry of Education, Youth and Sports of the Czech Republic
67985823 RVO CEP - Centrální evidence projektů
NV17-30833A MZ0 CEP - Centrální evidence projektů

Maternal immune activation (MIA) during pregnancy represents an important environmental factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to investigate the impacts of MIA on the brain and behavior of adolescent and adult offspring, as a rat model of these neurodevelopmental disorders. We injected bacterial lipopolysaccharide (LPS, 1 mg/kg) to pregnant Wistar dams from gestational day 7, every other day, up to delivery. Behavior of the offspring was examined in a comprehensive battery of tasks at postnatal days P45 and P90. Several brain parameters were analyzed at P28. The results showed that prenatal immune activation caused social and communication impairments in the adult offspring of both sexes; males were affected already in adolescence. MIA also caused prepulse inhibition deficit in females and increased the startle reaction in males. Anxiety and hypolocomotion were apparent in LPS-affected males and females. In the 28-day-old LPS offspring, we found enlargement of the brain and decreased numbers of parvalbumin-positive interneurons in the frontal cortex in both sexes. To conclude, our data indicate that sex of the offspring plays a crucial role in the development of the MIA-induced behavioral alterations, whereas changes in the brain apparent in young animals are sex-independent.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019014
003      
CZ-PrNML
005      
20210830100551.0
007      
ta
008      
210728s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms22063274 $2 doi
035    __
$a (PubMed)33806936
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Vojtechova, Iveta $u National Institute of Mental Health, Topolova 748, 25067 Klecany, Czech Republic $u Laboratory of the Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic $u First Faculty of Medicine, Charles University, Katerinska 32, 12108 Prague 2, Czech Republic
245    10
$a Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters / $c I. Vojtechova, K. Maleninska, V. Kutna, O. Klovrza, K. Tuckova, T. Petrasek, A. Stuchlik
520    9_
$a Maternal immune activation (MIA) during pregnancy represents an important environmental factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to investigate the impacts of MIA on the brain and behavior of adolescent and adult offspring, as a rat model of these neurodevelopmental disorders. We injected bacterial lipopolysaccharide (LPS, 1 mg/kg) to pregnant Wistar dams from gestational day 7, every other day, up to delivery. Behavior of the offspring was examined in a comprehensive battery of tasks at postnatal days P45 and P90. Several brain parameters were analyzed at P28. The results showed that prenatal immune activation caused social and communication impairments in the adult offspring of both sexes; males were affected already in adolescence. MIA also caused prepulse inhibition deficit in females and increased the startle reaction in males. Anxiety and hypolocomotion were apparent in LPS-affected males and females. In the 28-day-old LPS offspring, we found enlargement of the brain and decreased numbers of parvalbumin-positive interneurons in the frontal cortex in both sexes. To conclude, our data indicate that sex of the offspring plays a crucial role in the development of the MIA-induced behavioral alterations, whereas changes in the brain apparent in young animals are sex-independent.
650    _2
$a zvířata $7 D000818
650    12
$a chování zvířat $7 D001522
650    _2
$a mozek $x imunologie $x metabolismus $7 D001921
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a imunohistochemie $7 D007150
650    12
$a imunomodulace $7 D056747
650    _2
$a interneurony $x metabolismus $7 D007395
650    _2
$a lipopolysacharidy $x imunologie $7 D008070
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a matka - expozice noxám $7 D018811
650    _2
$a mikroglie $x imunologie $x metabolismus $7 D017628
650    _2
$a parvalbuminy $x metabolismus $7 D010320
650    _2
$a těhotenství $7 D011247
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a sexuální faktory $7 D012737
650    _2
$a sociální chování $7 D012919
655    _2
$a časopisecké články $7 D016428
700    1_
$a Maleninska, Kristyna $u National Institute of Mental Health, Topolova 748, 25067 Klecany, Czech Republic $u Laboratory of the Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic $u Faculty of Science, Charles University, Albertov 6, 12800 Prague 2, Czech Republic
700    1_
$a Kutna, Viera $u National Institute of Mental Health, Topolova 748, 25067 Klecany, Czech Republic
700    1_
$a Klovrza, Ondrej $u National Institute of Mental Health, Topolova 748, 25067 Klecany, Czech Republic
700    1_
$a Tuckova, Klara $u National Institute of Mental Health, Topolova 748, 25067 Klecany, Czech Republic $u Faculty of Science, Charles University, Albertov 6, 12800 Prague 2, Czech Republic
700    1_
$a Petrasek, Tomas $u National Institute of Mental Health, Topolova 748, 25067 Klecany, Czech Republic $u Laboratory of the Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic
700    1_
$a Stuchlik, Ales $u Laboratory of the Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 22, č. 6 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33806936 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830100551 $b ABA008
999    __
$a ok $b bmc $g 1689942 $s 1139460
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 22 $c 6 $e 20210323 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a 19-03016S $p Czech Science Foundation (GACR)
GRA    __
$a 17-30833A $p Czech Health Research Council (AZV)
GRA    __
$a 172515 $p Grant agency of the Charles University (GA UK)
GRA    __
$a National Institute of Mental Health - NIMH, IN: 00023752 $p MH CZ - DRO
GRA    __
$a LO1611 $p Ministry of Education, Youth and Sports of the Czech Republic
GRA    __
$a 67985823 $p RVO
GRA    __
$a NV17-30833A $p MZ0
LZP    __
$a Pubmed-20210728
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace