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Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

V. Vimberg, JP. Cavanagh, M. Novotna, J. Lenart, B. Nguyen Thi Ngoc, J. Vesela, M. Pain, M. Koberska, G. Balikova Novotna

. 2020 ; 64 (11) : . [pub] 20201020

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019969
E-zdroje Online Plný text

NLK Free Medical Journals od 1972 do Před 6 měsíci
Freely Accessible Science Journals od 1995 do Před 6 měsíci
PubMed Central od 1972 do Před 1 rokem
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Open Access Digital Library od 1972-01-01

Odkazy

PubMed 32816732
DOI 10.1128/aac.00666-20
Knihovny.cz E-zdroje

Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LSAP) by displacing antibiotics from the ribosome. Here, we show that expression of vga(A) variants from Staphylococcus haemolyticus is regulated by cis-regulatory RNA in response to the LSAP antibiotics by the mechanism of ribosome-mediated attenuation. The specificity of induction depends on Vga(A)-mediated resistance rather than on the sequence of the riboregulator. Fine tuning between Vga(A) activity and its expression in response to the antibiotics may contribute to the selection of more potent Vga(A) variants because newly acquired mutation can be immediately phenotypically manifested.

Citace poskytuje Crossref.org

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