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Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants
V. Vimberg, JP. Cavanagh, M. Novotna, J. Lenart, B. Nguyen Thi Ngoc, J. Vesela, M. Pain, M. Koberska, G. Balikova Novotna
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1972 to 6 months ago
Freely Accessible Science Journals
from 1995 to 6 months ago
PubMed Central
from 1972 to 1 year ago
Europe PubMed Central
from 1972 to 6 months ago
Open Access Digital Library
from 1972-01-01
Open Access Digital Library
from 1972-01-01
PubMed
32816732
DOI
10.1128/aac.00666-20
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacterial Proteins genetics MeSH
- Lincosamides MeSH
- Macrolides MeSH
- Drug Resistance, Multiple, Bacterial * MeSH
- Ribosomes genetics MeSH
- Streptogramin A * MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LSAP) by displacing antibiotics from the ribosome. Here, we show that expression of vga(A) variants from Staphylococcus haemolyticus is regulated by cis-regulatory RNA in response to the LSAP antibiotics by the mechanism of ribosome-mediated attenuation. The specificity of induction depends on Vga(A)-mediated resistance rather than on the sequence of the riboregulator. Fine tuning between Vga(A) activity and its expression in response to the antibiotics may contribute to the selection of more potent Vga(A) variants because newly acquired mutation can be immediately phenotypically manifested.
Department of Clinical Medicine UiT The Arctic University of Norway Tromsø Norway
Department of Genetics and Microbiology Faculty of Science Charles University Prague Czech Republic
Department of Pediatrics University Hospital of North Norway Tromsø Norway
Institute of Microbiology of the Czech Academy of Sciences Vestec Czech Republic
References provided by Crossref.org
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