• Something wrong with this record ?

Substitution-Inert Polynuclear Platinum Complexes Inhibit Reverse Transcription Preferentially in RNA Triplex-Forming Templates

J. Malina, NP. Farrell, V. Brabec

. 2020 ; 59 (20) : 15135-15143. [pub] 20200929

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21019970

RNA triplexes are significant tertiary structure motifs that are found in many functional RNAs. Hence, small molecules capable of recognition, binding, and stabilization of the triple-helical RNA structures are emerging as attractive potential molecular biology tools and therapeutic agents. Here, we utilize methods of molecular biology and biophysics to study the interactions of a series of antitumor substitution-inert polynuclear platinum complexes (SI-PPCs) with triple-helical RNA structures. We show that SI-PPCs recognize and stabilize RNA triplexes and inhibit reverse transcription preferentially in the RNA template prone to the triplex formation. These so far unexplored properties of SI-PPCs suggest that the targeting of triple-stranded regions in RNA might contribute to the biological effects of SI-PPCs.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019970
003      
CZ-PrNML
005      
20210830101552.0
007      
ta
008      
210728s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1021/acs.inorgchem.0c02070 $2 doi
035    __
$a (PubMed)32988198
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Malina, Jaroslav $u Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, Brno CZ-61265, Czech Republic
245    10
$a Substitution-Inert Polynuclear Platinum Complexes Inhibit Reverse Transcription Preferentially in RNA Triplex-Forming Templates / $c J. Malina, NP. Farrell, V. Brabec
520    9_
$a RNA triplexes are significant tertiary structure motifs that are found in many functional RNAs. Hence, small molecules capable of recognition, binding, and stabilization of the triple-helical RNA structures are emerging as attractive potential molecular biology tools and therapeutic agents. Here, we utilize methods of molecular biology and biophysics to study the interactions of a series of antitumor substitution-inert polynuclear platinum complexes (SI-PPCs) with triple-helical RNA structures. We show that SI-PPCs recognize and stabilize RNA triplexes and inhibit reverse transcription preferentially in the RNA template prone to the triplex formation. These so far unexplored properties of SI-PPCs suggest that the targeting of triple-stranded regions in RNA might contribute to the biological effects of SI-PPCs.
650    _2
$a protinádorové látky $x chemie $7 D000970
650    _2
$a sekvence nukleotidů $7 D001483
650    _2
$a komplexní sloučeniny $x chemie $7 D056831
650    _2
$a konformace nukleové kyseliny $7 D009690
650    _2
$a platina $x chemie $7 D010984
650    _2
$a RNA $x chemie $7 D012313
650    _2
$a reverzní transkripce $x účinky léků $7 D048348
655    _2
$a časopisecké články $7 D016428
700    1_
$a Farrell, Nicholas P $u Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284-2006, United States
700    1_
$a Brabec, Viktor $u Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, Brno CZ-61265, Czech Republic
773    0_
$w MED00006467 $t Inorganic chemistry $x 1520-510X $g Roč. 59, č. 20 (2020), s. 15135-15143
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32988198 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830101552 $b ABA008
999    __
$a ok $b bmc $g 1690708 $s 1140416
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 59 $c 20 $d 15135-15143 $e 20200929 $i 1520-510X $m Inorganic chemistry $n Inorg Chem $x MED00006467
LZP    __
$a Pubmed-20210728

Find record

Citation metrics

Archiving options