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Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions

HP. Yu, FC. Liu, CY. Lin, A. Umoro, J. Trousil, TL. Hwang, JY. Fang

. 2020 ; 15 (8) : 773-791. [pub] 20200320

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21020663
E-zdroje Online Plný text

NLK PubMed Central od 2015 do Před 1 rokem
ProQuest Central od 2006-06-01 do 2021-01-31
Health & Medicine (ProQuest) od 2006-06-01 do 2021-01-31

Odkazy

PubMed 32193978
DOI 10.2217/nnm-2019-0407
Knihovny.cz E-zdroje

Aim: We aimed to develop nanoemulsions containing phosphodiesterase 4 inhibitor rolipram with different droplet sizes, to evaluate the anti-inflammatory effect against activated neutrophils and a related lung injury. Materials & methods: We prepared nanoemulsions of three different sizes, 68, 133 and 188 nm. Results: The nanoemulsion inhibited the superoxide anion but not elastase release in primary human neutrophils. The large-sized nanoemulsions were mostly internalized by neutrophils, resulting in the reduction of intracellular Ca2+ half-life. The peripheral organ distribution of near-infrared dye-tagged nanoemulsions increased, following the decrease in droplet diameter. Rolipram entrapment into intravenous nanoemulsions ameliorated pulmonary inflammation. The smallest droplet size showed improvement, compared with the largest size. Conclusion: We established a foundation for the development of nanoemulsions against inflamed lung disease.

Citace poskytuje Crossref.org

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