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Synergistic effect of sclerostin and angiotensin II receptor 1 polymorphism on arterial stiffening
O. Mayer, J. Seidlerová, R. Kučera, A. Kučerová, V. Černá, J. Gelžinský, M. Mateřánková, Š. Mareš, V. Kordíková, M. Pešta, O. Topolčan, R. Cífková, J. Filipovský
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NV15-27109A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Health & Medicine (ProQuest) od 2007-06-01 do 2021-01-31
Public Health Database (ProQuest) od 2007-06-01 do 2021-01-31
Odkazy
PubMed
32057249
DOI
10.2217/bmm-2019-0249
Knihovny.cz E-zdroje
- MeSH
- adaptorové proteiny signální transdukční genetika MeSH
- analýza pulzové vlny MeSH
- dospělí MeSH
- genetická predispozice k nemoci genetika MeSH
- jednonukleotidový polymorfismus * MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- progrese nemoci MeSH
- receptor angiotensinu typ 1 genetika MeSH
- senioři MeSH
- tuhost cévní stěny genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Aim: We aimed to establish the association between sclerostin (a glycoprotein involved in bone metabolism) and development of pulse wave velocity (PWV) in the general population. Methods: A prospective cohort study with a total of 522 subjects. Aortic PWV was measured twice (at baseline and after approximately 8 years of follow-up) and intraindividual change in PWV per year (ΔPWV/year) was calculated. Results: ΔPWV/year increased across the sclerostin quintiles, but generally in a strong age-dependent manner. However, a significant independent positive association between sclerostin and ΔPWV/year was observed exclusively in C allele carriers of rs5186 polymorphism for the angiotensin II receptor 1 (n = 246). Conclusion: Sclerostin concentrations were associated with an accelerated natural course of arterial stiffening, but only in interaction with renin-angiotension system.
Biomedical Center Medical Faculty of Charles University Pilsen Czech Republic
Department of Biology Medical Faculty of Charles University Pilsen Czech Republic
Department of Immunodiagnostics University Hospital Pilsen Czech Republic
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- $a Aim: We aimed to establish the association between sclerostin (a glycoprotein involved in bone metabolism) and development of pulse wave velocity (PWV) in the general population. Methods: A prospective cohort study with a total of 522 subjects. Aortic PWV was measured twice (at baseline and after approximately 8 years of follow-up) and intraindividual change in PWV per year (ΔPWV/year) was calculated. Results: ΔPWV/year increased across the sclerostin quintiles, but generally in a strong age-dependent manner. However, a significant independent positive association between sclerostin and ΔPWV/year was observed exclusively in C allele carriers of rs5186 polymorphism for the angiotensin II receptor 1 (n = 246). Conclusion: Sclerostin concentrations were associated with an accelerated natural course of arterial stiffening, but only in interaction with renin-angiotension system.
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