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Indications and Results of Sternal Allograft Transplantation: Learning From a Worldwide Experience

A. Dell'Amore, M. Kalab, AS. Miller, G. Dolci, V. Liparulo, FS. Beigee, L. Rosso, P. Ferrigno, A. Pangoni, M. Schiavon, T. Bottio, F. Puma, V. Lonsky, F. Rea

. 2021 ; 112 (1) : 238-247. [pub] 20201017

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc21025424

BACKGROUND: Reconstruction of the anterior chest wall defect after sternectomy is a challenge for cardiothoracic surgeons. In 2010, the Padua group published the first case of cadaveric sternum transplantation after sternectomy. This multicenter study reports the clinical indications and early and long-term results of sternal chondral allograft transplantation. METHODS: This is a retrospective multicenter study from 7 academic centers. We collected demographic data, surgical indications, technical details, and early postoperative results. The complications, long-term stability, and tolerance of the allografts were also analyzed. RESULTS: Between January 2008 and December 2019, 58 patients underwent sternectomy followed by reconstruction using cadaveric-cryopreserved sternochondral allografts. Thirty-two patients were male, median age 63.5 years (interquartile range, 50-72 years). Indications for sternectomy were secondary sternal tumors (n = 13), primary sternal tumors (n = 15), and nonneoplastic disease (n = 30). Thirty patients underwent total sternectomy, 16 lower-body sternectomy, and 12 upper-body manubrium resection. The 30-day mortality was 5%; overall morbidity was 31%. Six early reoperations were necessary because of bleeding (n = 1), titanium plate dislocation (n = 1), and resuture of the skin in the lower part of the incision (n = 4). Overall, 5-year survival was 74%. In all the survived patients, the reconstructions were stable and free from mechanical or infective complications. CONCLUSIONS: The main indications for sternal allograft implantation were complex poststernotomy dehiscence followed by primary or secondary tumor involvement of the sternum. The collected results demonstrate that sternochondral allograft transplantation is a safe and effective method in reconstructing the anterior chest wall after sternectomy. Further studies to demonstrate the integration of the bone grafts into the patients' sternal wall will be made.

Citace poskytuje Crossref.org

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$a BACKGROUND: Reconstruction of the anterior chest wall defect after sternectomy is a challenge for cardiothoracic surgeons. In 2010, the Padua group published the first case of cadaveric sternum transplantation after sternectomy. This multicenter study reports the clinical indications and early and long-term results of sternal chondral allograft transplantation. METHODS: This is a retrospective multicenter study from 7 academic centers. We collected demographic data, surgical indications, technical details, and early postoperative results. The complications, long-term stability, and tolerance of the allografts were also analyzed. RESULTS: Between January 2008 and December 2019, 58 patients underwent sternectomy followed by reconstruction using cadaveric-cryopreserved sternochondral allografts. Thirty-two patients were male, median age 63.5 years (interquartile range, 50-72 years). Indications for sternectomy were secondary sternal tumors (n = 13), primary sternal tumors (n = 15), and nonneoplastic disease (n = 30). Thirty patients underwent total sternectomy, 16 lower-body sternectomy, and 12 upper-body manubrium resection. The 30-day mortality was 5%; overall morbidity was 31%. Six early reoperations were necessary because of bleeding (n = 1), titanium plate dislocation (n = 1), and resuture of the skin in the lower part of the incision (n = 4). Overall, 5-year survival was 74%. In all the survived patients, the reconstructions were stable and free from mechanical or infective complications. CONCLUSIONS: The main indications for sternal allograft implantation were complex poststernotomy dehiscence followed by primary or secondary tumor involvement of the sternum. The collected results demonstrate that sternochondral allograft transplantation is a safe and effective method in reconstructing the anterior chest wall after sternectomy. Further studies to demonstrate the integration of the bone grafts into the patients' sternal wall will be made.
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$a Kalab, Martin $u Department of Cardiac Surgery, University Hospital, Olmouc, Czech Republic
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$a Miller, Archibald Sandford $u Department of Plastic Surgery, Oklahoma State University, Center for Health Sciences, Tulsa, Oklahoma
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$a Dolci, Giampiero $u Department of Cardiothoracic Surgery, Policlinico S. Orsola-Malpighi, Bologna, Italy
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$a Liparulo, Valeria $u General Thoracic Surgery Unit, University of Perugia, Perugia, Italy
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$a Beigee, Farahnaz Sadegh $u Department of Thoracic Surgery, University Medical Sciences Tehran, Tehran, Iran
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$a Rosso, Lorenzo $u Thoracic Surgery and Lung Transplant Unit, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
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$a Ferrigno, Pia $u Thoracic Surgery Unit, Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy
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$a Pangoni, Alessandro $u Thoracic Surgery Unit, Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy
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$a Schiavon, Marco $u Thoracic Surgery Unit, Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy
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$a Puma, Francesco $u General Thoracic Surgery Unit, University of Perugia, Perugia, Italy
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$a Lonsky, Vladimir $u Department of Cardiac Surgery, University Hospital, Olmouc, Czech Republic
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