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Generation of three human iPSC lines from PLAN (PLA2G6-associated neurodegeneration) patients

C. Machuca, M. Correa-Vela, D. García-Navas, A. Darling, I. Villalón-García, JA. Sánchez-Alcázar, B. Pérez-Dueñas, S. Erceg, C. Espinós

. 2021 ; 53 (-) : 102338. [pub] 20210415

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21025815

The human iPSC cell lines, PLANFiPS1-Sv4F-1 (RCPFi004-A), PLANFiPS2-Sv4F-1 (RCPFi005-A), PLANFiPS3-Sv4F-1 RCPFi006-A), derived from dermal fibroblast from three patients suffering PLAN (PLA2G6-associated neurodegeneration; MIM 256600) caused by mutations in the PLA2G6 gene, was generated by non-integrative reprogramming technology using OCT3/4, SOX2, CMYC and KLF4 reprogramming factors. The pluripotency was assessed by immunocytochemistry and RT-PCR. Differentiation capacity was verified in vitro. This iPSC line can be further differentiated toward affected cells to better understand molecular mechanisms of disease and pathophysiology.

Citace poskytuje Crossref.org

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