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Centro Andaluz de Biología del Desarr... 1 Centro de Investigación Biomédica en ... 1 Department of Genetics Universitat de... 1 Department of Pediatric Neurology Hos... 1 Department of Pediatric Neurology Hos... 1 Institute of Experimental Medicine De... 1 National Stem Cell Bank Valencia Node... 1 Rare Diseases Joint Units CIPF IIS La... 1 Stem Cells Therapies in Neurodegenera... 1 Unit of Pediatric Movement Disorders ... 1 Unit of Rare Neurodegenerative Diseas... 1 Universitat Autònoma de Barcelona Bar... 1
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Centro Andaluz de Biología del Desarr... 1 Centro de Investigación Biomédica en ... 1 Department of Genetics Universitat de... 1 Department of Pediatric Neurology Hos... 1 Department of Pediatric Neurology Hos... 1 Institute of Experimental Medicine De... 1 National Stem Cell Bank Valencia Node... 1 Rare Diseases Joint Units CIPF IIS La... 1 Stem Cells Therapies in Neurodegenera... 1 Unit of Pediatric Movement Disorders ... 1 Unit of Rare Neurodegenerative Diseas... 1 Universitat Autònoma de Barcelona Bar... 1
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Machuca, Candela
Autor Machuca, Candela Unit of Rare Neurodegenerative Diseases, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain Rare Diseases Joint Units, CIPF-IIS La Fe & INCLIVA, Valencia, Spain Stem Cells Therapies in Neurodegenerative Diseases Lab, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain
- Correa-Vela, Marta
- García-Navas, Deyanira
- Darling, Alejandra
- Villalón-García, Irene
- Sánchez-Alcázar, José Antonio
- Pérez-Dueñas, Belén
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Erceg, Slaven
Autor Erceg, Slaven Rare Diseases Joint Units, CIPF-IIS La Fe & INCLIVA, Valencia, Spain Stem Cells Therapies in Neurodegenerative Diseases Lab, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain National Stem Cell Bank-Valencia Node, Biomolecular and Bioinformatics Resources Platform PRB2, ISCIII, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain Institute of Experimental Medicine, Department of Tissue Cultures and Stem Cells, Czech Academy of Sciences, Prague, Czech Republic
- Espinós, Carmen
Open Access Digital Library od 2007-10-01
Open Access Digital Library od 2014-01-01
Elsevier Open Access Journals od 2007-10-01
ROAD: Directory of Open Access Scholarly Resources od 2007
PubMed
34087982
DOI
10.1016/j.scr.2021.102338
Knihovny.cz E-zdroje
The human iPSC cell lines, PLANFiPS1-Sv4F-1 (RCPFi004-A), PLANFiPS2-Sv4F-1 (RCPFi005-A), PLANFiPS3-Sv4F-1 RCPFi006-A), derived from dermal fibroblast from three patients suffering PLAN (PLA2G6-associated neurodegeneration; MIM 256600) caused by mutations in the PLA2G6 gene, was generated by non-integrative reprogramming technology using OCT3/4, SOX2, CMYC and KLF4 reprogramming factors. The pluripotency was assessed by immunocytochemistry and RT-PCR. Differentiation capacity was verified in vitro. This iPSC line can be further differentiated toward affected cells to better understand molecular mechanisms of disease and pathophysiology.
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