Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs

JM. Pericàs, J. Llopis, E. Athan, M. Hernández-Meneses, MM. Hannan, DR. Murdoch, Z. Kanafani, T. Freiberger, J. Strahilevitz, N. Fernández-Hidalgo, C. Lamas, E. Durante-Mangoni, P. Tattevin, F. Nacinovich, VH. Chu, JM. Miró, International...

. 2021 ; 77 (5) : 544-555. [pub] 20210209

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026081

BACKGROUND: Infective endocarditis (IE) in people who inject drugs (PWID) is an emergent public health problem. OBJECTIVES: The purpose of this study was to investigate IE in PWID and compare it with IE in non-PWID patients. METHODS: Two prospective cohort studies (ICE-PCS and ICE-Plus databases, encompassing 8,112 IE episodes from 2000 to 2006 and 2008 to 2012, with 64 and 34 sites and 28 and 18 countries, respectively). Outcomes were compared between PWID and non-PWID patients with IE. Logistic regression analyses were performed to investigate risk factors for 6-month mortality and relapses amongst PWID. RESULTS: A total of 7,616 patients (591 PWID and 7,025 non-PWID) were included. PWID patients were significantly younger (median 37.0 years [interquartile range: 29.5 to 44.2 years] vs. 63.3 years [interquartile range: 49.3 to 74.0 years]; p < 0.001), male (72.5% vs. 67.4%; p = 0.007), and presented lower rates of comorbidities except for human immunodeficiency virus, liver disease, and higher rates of prior IE. Amongst IE cases in PWID, 313 (53%) episodes involved left-side valves and 204 (34.5%) were purely left-sided IE. PWID presented a larger proportion of native IE (90.2% vs. 64.4%; p < 0.001), whereas prosthetic-IE and cardiovascular implantable electronic device-IE were more frequent in non-PWID (9.3% vs. 27.0% and 0.5% vs. 8.6%; both p < 0.001). Staphylococcus aureus caused 65.9% and 26.8% of cases in PWID and non-PWID, respectively (p < 0.001). PWID presented higher rates of systemic emboli (51.1% vs. 22.5%; p < 0.001) and persistent bacteremia (14.7% vs. 9.3%; p < 0.001). Cardiac surgery was less frequently performed (39.5% vs. 47.8%; p < 0.001), and in-hospital and 6-month mortality were lower in PWID (10.8% vs. 18.2% and 14.4% vs. 22.2%; both p < 0.001), whereas relapses were more frequent in PWID (9.5% vs. 2.8%; p < 0.001). Prior IE, left-sided IE, polymicrobial etiology, intracardiac complications, and stroke were risk factors for 6-month mortality, whereas cardiac surgery was associated with lower mortality in the PWID population. CONCLUSIONS: A notable proportion of cases in PWID involve left-sided valves, prosthetic valves, or are caused by microorganisms other than S. aureus.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21026081
003      
CZ-PrNML
005      
20211026133226.0
007      
ta
008      
211013s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.jacc.2020.11.062 $2 doi
035    __
$a (PubMed)33538252
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Pericàs, Juan M $u Infectious Diseases Department, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain
245    10
$a Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs / $c JM. Pericàs, J. Llopis, E. Athan, M. Hernández-Meneses, MM. Hannan, DR. Murdoch, Z. Kanafani, T. Freiberger, J. Strahilevitz, N. Fernández-Hidalgo, C. Lamas, E. Durante-Mangoni, P. Tattevin, F. Nacinovich, VH. Chu, JM. Miró, International Collaboration on Endocarditis (ICE) Investigators
520    9_
$a BACKGROUND: Infective endocarditis (IE) in people who inject drugs (PWID) is an emergent public health problem. OBJECTIVES: The purpose of this study was to investigate IE in PWID and compare it with IE in non-PWID patients. METHODS: Two prospective cohort studies (ICE-PCS and ICE-Plus databases, encompassing 8,112 IE episodes from 2000 to 2006 and 2008 to 2012, with 64 and 34 sites and 28 and 18 countries, respectively). Outcomes were compared between PWID and non-PWID patients with IE. Logistic regression analyses were performed to investigate risk factors for 6-month mortality and relapses amongst PWID. RESULTS: A total of 7,616 patients (591 PWID and 7,025 non-PWID) were included. PWID patients were significantly younger (median 37.0 years [interquartile range: 29.5 to 44.2 years] vs. 63.3 years [interquartile range: 49.3 to 74.0 years]; p < 0.001), male (72.5% vs. 67.4%; p = 0.007), and presented lower rates of comorbidities except for human immunodeficiency virus, liver disease, and higher rates of prior IE. Amongst IE cases in PWID, 313 (53%) episodes involved left-side valves and 204 (34.5%) were purely left-sided IE. PWID presented a larger proportion of native IE (90.2% vs. 64.4%; p < 0.001), whereas prosthetic-IE and cardiovascular implantable electronic device-IE were more frequent in non-PWID (9.3% vs. 27.0% and 0.5% vs. 8.6%; both p < 0.001). Staphylococcus aureus caused 65.9% and 26.8% of cases in PWID and non-PWID, respectively (p < 0.001). PWID presented higher rates of systemic emboli (51.1% vs. 22.5%; p < 0.001) and persistent bacteremia (14.7% vs. 9.3%; p < 0.001). Cardiac surgery was less frequently performed (39.5% vs. 47.8%; p < 0.001), and in-hospital and 6-month mortality were lower in PWID (10.8% vs. 18.2% and 14.4% vs. 22.2%; both p < 0.001), whereas relapses were more frequent in PWID (9.5% vs. 2.8%; p < 0.001). Prior IE, left-sided IE, polymicrobial etiology, intracardiac complications, and stroke were risk factors for 6-month mortality, whereas cardiac surgery was associated with lower mortality in the PWID population. CONCLUSIONS: A notable proportion of cases in PWID involve left-sided valves, prosthetic valves, or are caused by microorganisms other than S. aureus.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a endokarditida $x epidemiologie $x etiologie $7 D004696
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a celosvětové zdraví $7 D014943
650    _2
$a lidé $7 D006801
650    _2
$a incidence $7 D015994
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a prospektivní studie $7 D011446
650    _2
$a hodnocení rizik $x metody $7 D018570
650    _2
$a rizikové faktory $7 D012307
650    _2
$a intravenózní abúzus drog $x komplikace $x epidemiologie $7 D015819
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a pozorovací studie $7 D064888
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Llopis, Jaume $u Infectious Diseases Department, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain; Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain
700    1_
$a Athan, Eugene $u Department of Infectious Disease, Barwon Health and Deakin University, Geelong, Australia
700    1_
$a Hernández-Meneses, Marta $u Infectious Diseases Department, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain
700    1_
$a Hannan, Margaret M $u Department of Microbiology, Mater Misericordiae University Hospital, Dublin, Ireland
700    1_
$a Murdoch, David R $u Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand
700    1_
$a Kanafani, Zeina $u Division of Infectious Diseases, American University of Beirut, Beirut, Lebanon
700    1_
$a Freiberger, Tomas $u Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic; Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Strahilevitz, Jacob $u Hadassah-Hebrew University Medical Center, Jerusalem, Israel
700    1_
$a Fernández-Hidalgo, Nuria $u Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
700    1_
$a Lamas, Cristiane $u Instituto Nacional de Cardiologia and Unigranrio, Rio de Janeiro, Brazil
700    1_
$a Durante-Mangoni, Emanuele $u Internal Medicine, University of Campania, Monaldi Hospital, Naples, Italy
700    1_
$a Tattevin, Pierre $u Infectious diseases and intensive care unit, Pontchaillou University Hospital, Rennes, France
700    1_
$a Nacinovich, Francisco $u Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina
700    1_
$a Chu, Vivian H $u Duke University School of Medicine, Durham, North Carolina, USA
700    1_
$a Miró, José M $u Infectious Diseases Department, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. Electronic address: jmmiro@ub.edu
710    2_
$a International Collaboration on Endocarditis (ICE) Investigators
773    0_
$w MED00002964 $t Journal of the American College of Cardiology $x 1558-3597 $g Roč. 77, č. 5 (2021), s. 544-555
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33538252 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211026133232 $b ABA008
999    __
$a ok $b bmc $g 1714942 $s 1146588
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 77 $c 5 $d 544-555 $e 20210209 $i 1558-3597 $m Journal of the American College of Cardiology $n J. Am. Coll. Cardiol. $x MED00002964
LZP    __
$a Pubmed-20211013

Najít záznam

Citační ukazatele

Možnosti archivace