-
Something wrong with this record ?
Src kinase: Key effector in mechanosignalling
L. Koudelková, J. Brábek, D. Rosel
International journal of biochemistry and cell biology.
2021 ;
131 (-) :
105908.
[pub] 20201225
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Persistent link
https://www.medvik.cz/link/bmc21026123
- MeSH
- Adaptor Proteins, Signal Transducing genetics metabolism MeSH
- Mechanotransduction, Cellular genetics MeSH
- Cytoskeleton metabolism pathology ultrastructure MeSH
- Extracellular Matrix metabolism pathology ultrastructure MeSH
- Integrins genetics metabolism MeSH
- Humans MeSH
- Stress, Mechanical MeSH
- Neoplasms genetics metabolism pathology MeSH
- Protein Serine-Threonine Kinases genetics metabolism MeSH
- Gene Expression Regulation MeSH
- src-Family Kinases genetics metabolism MeSH
- Crk-Associated Substrate Protein genetics metabolism MeSH
- Transcription Factors genetics metabolism MeSH
- Receptor-Like Protein Tyrosine Phosphatases, Class 4 genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Cells have developed a unique set of molecular mechanisms that allows them to probe mechanical properties of the surrounding environment. These systems are based on deformable primary mechanosensors coupled to tension transmitting proteins and enzymes generating biochemical signals. This modular setup enables to transform a mechanical load into more versatile biochemical information. Src kinase appears to be one of the central components of the mechanotransduction network mediating force-induced signalling across multiple cellular contexts. In tight cooperation with primary sensors and the cytoskeleton, Src functions as an effector molecule necessary for transformation of mechanical stimuli into biochemical outputs executing cellular response and adaptation to mechanical cues.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21026123
- 003
- CZ-PrNML
- 005
- 20220119144226.0
- 007
- ta
- 008
- 211013s2021 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.biocel.2020.105908 $2 doi
- 035 __
- $a (PubMed)33359015
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Koudelková, Lenka $u Department of Cell Biology, Charles University, 12800, Prague, Czech Republic; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), 25250, Vestec, Czech Republic
- 245 10
- $a Src kinase: Key effector in mechanosignalling / $c L. Koudelková, J. Brábek, D. Rosel
- 520 9_
- $a Cells have developed a unique set of molecular mechanisms that allows them to probe mechanical properties of the surrounding environment. These systems are based on deformable primary mechanosensors coupled to tension transmitting proteins and enzymes generating biochemical signals. This modular setup enables to transform a mechanical load into more versatile biochemical information. Src kinase appears to be one of the central components of the mechanotransduction network mediating force-induced signalling across multiple cellular contexts. In tight cooperation with primary sensors and the cytoskeleton, Src functions as an effector molecule necessary for transformation of mechanical stimuli into biochemical outputs executing cellular response and adaptation to mechanical cues.
- 650 _2
- $a adaptorové proteiny signální transdukční $x genetika $x metabolismus $7 D048868
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a substrátový protein asociovaný s Crk $x genetika $x metabolismus $7 D050719
- 650 _2
- $a cytoskelet $x metabolismus $x patologie $x ultrastruktura $7 D003599
- 650 _2
- $a extracelulární matrix $x metabolismus $x patologie $x ultrastruktura $7 D005109
- 650 _2
- $a regulace genové exprese $7 D005786
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a integriny $x genetika $x metabolismus $7 D016023
- 650 _2
- $a buněčný převod mechanických signálů $x genetika $7 D040542
- 650 _2
- $a nádory $x genetika $x metabolismus $x patologie $7 D009369
- 650 _2
- $a protein-serin-threoninkinasy $x genetika $x metabolismus $7 D017346
- 650 _2
- $a tyrosinfosfatasy receptorového typu, třída 4 $x genetika $x metabolismus $7 D054630
- 650 _2
- $a mechanický stres $7 D013314
- 650 _2
- $a transkripční faktory $x genetika $x metabolismus $7 D014157
- 650 _2
- $a skupina kinas odvozených od src-genu $x genetika $x metabolismus $7 D019061
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Brábek, Jan, $u Department of Cell Biology, Charles University, 12800, Prague, Czech Republic; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), 25250, Vestec, Czech Republic $d 1973- $7 xx0268678
- 700 1_
- $a Rosel, Daniel $u Department of Cell Biology, Charles University, 12800, Prague, Czech Republic; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), 25250, Vestec, Czech Republic. Electronic address: rosel@natur.cuni.cz
- 773 0_
- $w MED00006475 $t The international journal of biochemistry & cell biology $x 1878-5875 $g Roč. 131, č. - (2021), s. 105908
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33359015 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20211013 $b ABA008
- 991 __
- $a 20220119144222 $b ABA008
- 999 __
- $a ok $b bmc $g 1714979 $s 1146630
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 131 $c - $d 105908 $e 20201225 $i 1878-5875 $m International journal of biochemistry and cell biology $n Int J Biochem Cell Biol $x MED00006475
- LZP __
- $a Pubmed-20211013
