The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those factors that can explain the large inter-individual and inter-laboratory variation. International collaborative initiatives such as the hCOMET project - a COST Action launched in 2016 - represent a valuable tool to meet this challenge. The aims of hCOMET were to establish reference values for the level of DNA damage in humans, to investigate the effect of host factors, lifestyle and exposure to genotoxic agents, and to compare different sources of assay variability. A database of 19,320 subjects was generated, pooling data from 105 studies run by 44 laboratories in 26 countries between 1999 and 2019. A mixed random effect log-linear model, in parallel with a classic meta-analysis, was applied to take into account the extensive heterogeneity of data, due to descriptor, specimen and protocol variability. As a result of this analysis interquartile intervals of DNA strand breaks (which includes alkali-labile sites) were reported for tail intensity, tail length, and tail moment (comet assay descriptors). A small variation by age was reported in some datasets, suggesting higher DNA damage in oldest age-classes, while no effect could be shown for sex or smoking habit, although the lack of data on heavy smokers has still to be considered. Finally, highly significant differences in DNA damage were found for most exposures investigated in specific studies. In conclusion, these data, which confirm that DNA damage measured by the comet assay is an excellent biomarker of exposure in several conditions, may contribute to improving the quality of study design and to the standardization of results of the comet assay in human populations.

ANTICIPE Unit INSERM and University of Caen Normandie Centre François Baclesse Avenue du Général Harris 14076 Caen Cedex 05 France

Biomedical Sciences Department University of Bradford Richmond Road Bradford Bradford West Yorkshire BD7 1DP UK

Biostatistics Unit San Martino Policlinic Hospital Genoa Italy

Cancer Research Institute Biomedical Research Center of the Slovak Academy of Sciences Dubravska cesta 9 845 05 Bratislava Slovakia

Center for Radiation Safety Technology and Metrology National Nuclear Energy Agency of Indonesia Jl LebakBulus Raya No 49 Kotak Pos 7043 JKSKL JakartaSelatan 12440 Jakarta Indonesia

Center for RadiationProtection and Hygiene Calle 20 No 4113 e 41 y 47 Playa C P 11300 La Habana A P 6195 C P 10600 Habana Cuba

Center of Biological Research Faculty of Pharmacy University of Belgrade VojvodeStepe 450 Belgrade Serbia

Centre for Molecular and Translational Oncology University of Parma Parco Area delle Scienze 11A 43124 Parma Italy

Consortium for Biomedical Research in Epidemiology and Public Health Carlos 3 Institute of Health 28029 Madrid Spain

Department NEUROFARBA University of Florence Viale G Pieraccini 6 50139 Florence Italy

Department of Biochemistry Instituto de Ciencias Básicas y Preclínicas Victoria de Giron 146 St and 31 Ave No 3102 Playa Habana Cuba

Department of Biology Faculty of Veterinary Medicine University of Belgrade Oslobodjenja Blvd 18 11000 Belgrade Serbia

Department of Biology University of Prishtina George Bush N N 10000 Prishtina Kosovo

Department of Chemistry Life Sciences and Environmental Sustainability University of Parma Parco Area delle Scienze 11A 43124 Parma Italy

Department of Environment and Health Istituto Superiore di Sanità Viale Regina Elena 299 Rome Italy

Department of Environmental Health Section of Molecular Toxicology Norwegian Institute of Public Health Lovisenberggt 6 0456 Oslo Norway

Department of Food Environmental and Nutritional Sciences University of Milan Via Celoria 2 20133 Milan Italy

Department of Genetics and Microbiology Faculty of Biosciences Universitat Autònoma de Barcelona 08193 Cerdanyola del Vallès Spain

Department of Health Sciences University of Florence Division of Dermatology Palagi Hospital Viale Michelangelo 41 Florence Italy

Department of Nanotoxicolgy and Molecular Epidemiology Institute of Experimental Medicine of the Czech Academy of Sciences Videnska 1083 Prague Czech Republic

Department of Non ionizing Radiation National Public Health Center Anna Street 5 1221 Budapest Hungary

Department of Nutrition Food Science and Physiology Centre for Nutrition Research University of Navarra Irunlarrea 1 31008 Pamplona Navarra Spain

Department of Nutrition Institute of Basic Medical Sciences University of Oslo Sognsvannsveien 9 0372 Oslo Norway

Department of Nutritional Sciences University of Vienna Althanstrasse 14 1090 Vienna Austria

Department of Occupational and Environmental Medicine Epidemiology and Hygiene Italy

Department of Pharmaceutical Sciences University of Perugia Via del Giochetto 06122 Perugia Italy

Department of Pharmaceutical Toxicology Faculty of Pharmacy Hacettepe University Ankara Turkey

Department of Pharmacology and Toxicology University of Navarra C Irunlarrea 1 31008 Pamplona Spain

Department of Public Health Section of Environmental Health University of Copenhagen Oster Farimagsgade 5A DK 1014 Copenhagen Denmark

Department of Radiation Hygiene and Radiobiology National Institute of Public Health National Institute of Hygiene 24 Chocimska Street 00 791 Warsaw Poland

Department of Toxicology and Military Pharmacy Faculty of Military Health Sciences University of Defence Trebesska 1575 500 01 Hradec Kralove Czech Republic

Environmental Health Department National Institute of Health Dr Ricardo Jorge Rua Alexandre Herculano 321 4000 055 Porto Portugal

EPIUnit Instituto de Saúde Pública Universidade do Porto Rua das Taipas no 135 4050 600 Porto Portugal

Experimental Medicine Molecular Biology of Cancer IEM AVCR Videnska 1083 Prague 4 Prague Czech Republic

Faculty of Medicine Clinic for Endocrinology Diabetes and Metabolic Disease University of Belgrade Dr Subotića 13 Belgrade Serbia

Flemish Institute of Technological Research Environmental Risk and Health unit VITO BIOMo Belgium

Genomic Medicine and EnvironmentalToxicology Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México CU Mexico

Grupo DICOMOSA Centro de Investigaciones Científicas Avanzadas Departamento de Biología Facultad de Ciencias Universidade da Coruña Campus A Zapateira s n 15071 A Coruña Spain

Grupo DICOMOSA Centro de Investigaciones Científicas Avanzadas Departamento de Psicología Facultad de Ciencias de la Educación Universidade da Coruña Campus Elviña s n 15071 A Coruña Spain

H and TRC Health and Technology Research Center ESTeSL Escola Superior de Tecnologia da Saúde Instituto Politécnico de Lisboa 1990 096 Lisbon Portugal

Human Genetics Department National Institute of Health Doutor Ricardo Jorge Av Padre Cruz 1649 016 Lisbon Portugal

IdiSNA Navarra Institute for Health Research C Irunlarrea 3 31008 Pamplona Spain

Institute for Medical Chemistry Biochemistry and Clinical Biochemistry Faculty of Medicine Comenius University Sasinkova 2 Bratislava Slovakia

Institute of Biology Medical Faculty Slovak Medical University Limbova 12 83303 Bratislava Slovakia

Institute of Pharmacology and Toxicology University of Wuerzburg VersbacherStrasse 9 97078 Wuerzburg Germany

Institute of Theoretical and Experimental Biophysics Russian Academy of Sciences 142290 Institutskaya 3 Pushchino Moscow Region Russia

IRCCS San Raffaele Pisana Unit of Clinical and Molecular Epidemiology Department of Human Sciences and Quality of Life Promotion San Raffaele University Via di Val Cannuta 247 00161 Rome Italy

Laboratory for the Study of the Pathogenesis of Malignant Tumors National Medical Research Center for Oncology 14 line 63 344037 Rostov on Don Russia

Laboratory of Genetic Toxicology Lutheran University of Brazil Av Farroupilha 8001 Prédio 22 Sala 22 92425 900 Canoas RS Brazil

Laboratory of Translational Biomedicine University of Southern Santa Catarina UNESC Criciúma SC Brazil

Memorial Sloan Kettering Cancer Center Epidemiology and Biostatistics New York New York 10065 USA

Mutagenesis Unit Institute for Medical Research and Occupational Health Ksaverska cesta 2 10000 Zagreb Croatia

NILU Health Effects Laboratory Kjeller Norway

NOVA National School of Public Health Public Health Research Centre Universidade NOVA de Lisboa Lisbon Portugal

School of Nutrition and Translational Research in Metabolism Department of Pharmacology and Toxicology University of Maastricht Universiteitssingel 50 6200 MD Maastricht the Netherlands

Toxalim Université de Toulouse INRAE ENVT INP Purpan UPS Toulouse France

Toxicology Department Faculty of Pharmacy Gazi University Ankara Turkey

Toxicology Department Faculty of Pharmacy Istinye University Istanbul Turkey

ToxOmics NMS NOVA University of Lisbon Lisbon Portugal

Univ Paris Saclay CESP Villejuif France

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$a The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders / $c M. Milić, M. Ceppi, M. Bruzzone, A. Azqueta, G. Brunborg, R. Godschalk, G. Koppen, S. Langie, P. Møller, JP. Teixeira, A. Alija, D. Anderson, V. Andrade, C. Andreoli, F. Asllani, EE. Bangkoglu, M. Barančoková, N. Basaran, E. Boutet-Robinet, A. Buschini, D. Cavallo, C. Costa Pereira, C. Costa, S. Costa, J. Da Silva, C. Del Boˊ, V. Dimitrijević Srećković, N. Djelić, M. Dobrzyńska, Z. Duračková, M. Dvořáková, G. Gajski, S. Galati, O. García Lima, L. Giovannelli, IA. Goroshinskaya, A. Grindel, KB. Gutzkow, A. Hernández, C. Hernández, KB. Holven, I. Ibero-Baraibar, I. Ottestad, E. Kadioglu, A. Kažimirová, E. Kuznetsova, C. Ladeira, B. Laffon, P. Lamonaca, P. Lebailly, H. Louro, T. Mandina Cardoso, F. Marcon, R. Marcos, M. Moretti, S. Moretti, M. Najafzadeh, Z. Nemeth, M. Neri, B. Novotna, I. Orlow, Z. Paduchova, S. Pastor, H. Perdry, B. Spremo-Potparević, D. Ramadhani, P. Riso, P. Rohr, E. Rojas, P. Rossner, A. Safar, S. Sardas, MJ. Silva, N. Sirota, B. Smolkova, M. Staruchova, R. Stetina, H. Stopper, EI. Surikova, SM. Ulven, CL. Ursini, V. Valdiglesias, M. Valverde, P. Vodicka, K. Volkovova, KH. Wagner, L. Živković, M. Dušinská, AR. Collins, S. Bonassi

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$a The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those factors that can explain the large inter-individual and inter-laboratory variation. International collaborative initiatives such as the hCOMET project - a COST Action launched in 2016 - represent a valuable tool to meet this challenge. The aims of hCOMET were to establish reference values for the level of DNA damage in humans, to investigate the effect of host factors, lifestyle and exposure to genotoxic agents, and to compare different sources of assay variability. A database of 19,320 subjects was generated, pooling data from 105 studies run by 44 laboratories in 26 countries between 1999 and 2019. A mixed random effect log-linear model, in parallel with a classic meta-analysis, was applied to take into account the extensive heterogeneity of data, due to descriptor, specimen and protocol variability. As a result of this analysis interquartile intervals of DNA strand breaks (which includes alkali-labile sites) were reported for tail intensity, tail length, and tail moment (comet assay descriptors). A small variation by age was reported in some datasets, suggesting higher DNA damage in oldest age-classes, while no effect could be shown for sex or smoking habit, although the lack of data on heavy smokers has still to be considered. Finally, highly significant differences in DNA damage were found for most exposures investigated in specific studies. In conclusion, these data, which confirm that DNA damage measured by the comet assay is an excellent biomarker of exposure in several conditions, may contribute to improving the quality of study design and to the standardization of results of the comet assay in human populations.

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700    1_

$a Bruzzone, Marco $u Biostatistics Unit, San Martino Policlinic Hospital, Genoa, Italy

700    1_

$a Azqueta, Amaya $u Department of Pharmacology and Toxicology, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, C/Irunlarrea 3, 31008, Pamplona, Spain

700    1_

$a Brunborg, Gunnar $u Department of Environmental Health, Section of Molecular Toxicology, Norwegian Institute of Public Health (NIPH), Lovisenberggt 6, 0456, Oslo, Norway

700    1_

$a Godschalk, Roger $u School of Nutrition and Translational Research in Metabolism, Department of Pharmacology and Toxicology, University of Maastricht, Universiteitssingel 50, 6200 MD, Maastricht, the Netherlands

700    1_

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700    1_

$a Langie, Sabine $u School of Nutrition and Translational Research in Metabolism, Department of Pharmacology and Toxicology, University of Maastricht, Universiteitssingel 50, 6200 MD, Maastricht, the Netherlands

700    1_

$a Møller, Peter $u Department of Public Health, Section of Environmental Health, University of Copenhagen, Oster Farimagsgade 5A, DK-1014, Copenhagen, Denmark

700    1_

$a Teixeira, João Paulo $u Environmental Health Department, National Institute of Health Dr. Ricardo Jorge, Rua Alexandre Herculano, 321, 4000-055, Porto, Portugal; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, no 135, 4050-600, Porto, Portugal

700    1_

$a Alija, Avdulla $u Department of Biology, University of Prishtina, George Bush, N.N., 10000, Prishtina, Kosovo

700    1_

$a Anderson, Diana $u Biomedical Sciences Department, University of Bradford, Richmond Road Bradford, Bradford, West Yorkshire, BD7 1DP, UK

700    1_

$a Andrade, Vanessa $u Laboratory of Translational Biomedicine, University of Southern Santa Catarina, UNESC, Criciúma, SC, Brazil

700    1_

$a Andreoli, Cristina $u Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy

700    1_

$a Asllani, Fisnik $u Department of Biology, University of Prishtina, George Bush, N.N., 10000, Prishtina, Kosovo

700    1_

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700    1_

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700    1_

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700    1_

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700    1_

$a Buschini, Annamaria $u Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11A, 43124, Parma, Italy

700    1_

$a Cavallo, Delia $u Department of Occupational and Environmental Medicine, Epidemiology and Hygiene (DiMEILA), Italian Workers' Compensation Authority (INAIL), Via Fontana Candida 1, 00078, Monte Porzio Catone(Rome), Italy

700    1_

$a Costa Pereira, Cristiana $u Environmental Health Department, National Institute of Health Dr. Ricardo Jorge, Rua Alexandre Herculano, 321, 4000-055, Porto, Portugal; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, no 135, 4050-600, Porto, Portugal

700    1_

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700    1_

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700    1_

$a Da Silva, Juliana $u Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA), Av. Farroupilha 8001, Prédio 22/Sala 22, 92425-900, Canoas, RS, Brazil

700    1_

$a Del Boˊ, Cristian $u Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Celoria 2, 20133, Milan, Italy

700    1_

$a Dimitrijević Srećković, Vesna $u Faculty of Medicine, Clinic for Endocrinology, Diabetes and Metabolic Disease, University of Belgrade, Dr Subotića 13, Belgrade, Serbia

700    1_

$a Djelić, Ninoslav $u Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, Oslobodjenja Blvd 18, 11000, Belgrade, Serbia

700    1_

$a Dobrzyńska, Malgorzata $u Department of Radiation Hygiene and Radiobiology, National Institute of Public Health - National Institute of Hygiene, 24 Chocimska Street, 00-791, Warsaw, Poland

700    1_

$a Duračková, Zdenka $u Institute for Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, Bratislava, Slovakia

700    1_

$a Dvořáková, Monika $u Institute for Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, Bratislava, Slovakia

700    1_

$a Gajski, Goran $u Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000, Zagreb, Croatia

700    1_

$a Galati, Serena $u Centre for Molecular and Translational Oncology, University of Parma, Parco Area delle Scienze 11A, 43124, Parma, Italy

700    1_

$a García Lima, Omar $u Center for RadiationProtection and Hygiene, Calle 20, No 4113, e/41 y 47. Playa. C.P. 11300, La Habana, A.P. 6195, C.P. 10600, Habana, Cuba

700    1_

$a Giovannelli, Lisa $u Department NEUROFARBA, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy

700    1_

$a Goroshinskaya, Irina A $u Laboratory for the Study of the Pathogenesis of Malignant Tumors, National Medical Research Center for Oncology, 14 line 63, 344037, Rostov-on-Don, Russia

700    1_

$a Grindel, Annemarie $u Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria

700    1_

$a Gutzkow, Kristine B $u Department of Environmental Health, Section of Molecular Toxicology, Norwegian Institute of Public Health (NIPH), Lovisenberggt 6, 0456, Oslo, Norway

700    1_

$a Hernández, Alba $u Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès (Barcelona), Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, 28029, Madrid, Spain

700    1_

$a Hernández, Carlos $u Department of Biochemistry, Instituto de Ciencias Básicas y Preclínicas "Victoria de Giron", 146 St. and 31 Ave, No 3102, Playa, Habana, Cuba

700    1_

$a Holven, Kirsten B $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway

700    1_

$a Ibero-Baraibar, Idoia $u Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Irunlarrea 1, 31008, Pamplona, Navarra, Spain

700    1_

$a Ottestad, Inger $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway

700    1_

$a Kadioglu, Ela $u Toxicology Department, Faculty of Pharmacy, Gazi University, Ankara, Turkey

700    1_

$a Kažimirová, Alena $u Institute of Biology, Medical Faculty, Slovak Medical University, Limbova 12, 83303, Bratislava, Slovakia

700    1_

$a Kuznetsova, Elena $u Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Institutskaya 3, Pushchino, Moscow Region, Russia

700    1_

$a Ladeira, Carina $u H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096, Lisbon, Portugal; NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisbon, Portugal

700    1_

$a Laffon, Blanca $u Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Psicología, Facultad de Ciencias de la Educación, Universidade da Coruña, Campus Elviña s/n, 15071, A Coruña, Spain

700    1_

$a Lamonaca, Palma $u IRCCS San Raffaele Pisana, Unit of Clinical and Molecular Epidemiology, Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Via di Val Cannuta, 247., 00161, Rome, Italy

700    1_

$a Lebailly, Pierre $u ANTICIPE Unit, INSERM &University of Caen-Normandie Centre François Baclesse, Avenue du Général Harris 14076, Caen Cedex 05, France

700    1_

$a Louro, Henriqueta $u Human Genetics Department, National Institute of Health Doutor Ricardo Jorge, Av. Padre Cruz, 1649-016, Lisbon, Portugal; ToxOmics, NMS, NOVA University of Lisbon, Lisbon, Portugal

700    1_

$a Mandina Cardoso, Tania $u Center for RadiationProtection and Hygiene, Calle 20, No 4113, e/41 y 47. Playa. C.P. 11300, La Habana, A.P. 6195, C.P. 10600, Habana, Cuba

700    1_

$a Marcon, Francesca $u Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy

700    1_

$a Marcos, Ricard $u Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès (Barcelona), Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, 28029, Madrid, Spain

700    1_

$a Moretti, Massimo $u Department of Pharmaceutical Sciences (Unit of Public Health), University of Perugia, Via del Giochetto, 06122, Perugia, Italy

700    1_

$a Moretti, Silvia $u Department of Health Sciences, University of Florence, Division of Dermatology, Palagi Hospital, Viale Michelangelo 41, Florence, Italy

700    1_

$a Najafzadeh, Mojgan $u Biomedical Sciences Department, University of Bradford, Richmond Road Bradford, Bradford, West Yorkshire, BD7 1DP, UK

700    1_

$a Nemeth, Zsuzsanna $u Department of Non-ionizing Radiation, National Public Health Center, Anna Street 5, 1221, Budapest, Hungary

700    1_

$a Neri, Monica $u IRCCS San Raffaele Pisana, Unit of Clinical and Molecular Epidemiology, Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Via di Val Cannuta, 247., 00161, Rome, Italy

700    1_

$a Novotna, Bozena $u Department of Nanotoxicolgy and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague, Czech Republic

700    1_

$a Orlow, Irene $u Memorial Sloan Kettering Cancer Center, Epidemiology and Biostatistics, New York, New York, 10065, USA

700    1_

$a Paduchova, Zuzana $u Institute for Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, Bratislava, Slovakia

700    1_

$a Pastor, Susana $u Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès (Barcelona), Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, 28029, Madrid, Spain

700    1_

$a Perdry, Hervé $u Univ Paris-Saclay, CESP, Villejuif, France

700    1_

$a Spremo-Potparević, Biljana $u Center of Biological Research, Faculty of Pharmacy, University of Belgrade, VojvodeStepe, 450, Belgrade, Serbia

700    1_

$a Ramadhani, Dwi $u Center for Radiation Safety Technology and Metrology, National Nuclear Energy Agency of Indonesia, Jl. LebakBulus Raya No. 49, Kotak Pos 7043 JKSKL JakartaSelatan, 12440, Jakarta, Indonesia

700    1_

$a Riso, Patrizia $u Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Celoria 2, 20133, Milan, Italy

700    1_

$a Rohr, Paula $u Laboratory of Translational Biomedicine, University of Southern Santa Catarina, UNESC, Criciúma, SC, Brazil

700    1_

$a Rojas, Emilio $u Genomic Medicine and EnvironmentalToxicology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, CU, Mexico

700    1_

$a Rossner, Pavel $u Department of Nanotoxicolgy and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague, Czech Republic

700    1_

$a Safar, Anna $u Department of Non-ionizing Radiation, National Public Health Center, Anna Street 5, 1221, Budapest, Hungary

700    1_

$a Sardas, Semra $u Toxicology Department, Faculty of Pharmacy, Istinye University, Istanbul, Turkey

700    1_

$a Silva, Maria João $u Human Genetics Department, National Institute of Health Doutor Ricardo Jorge, Av. Padre Cruz, 1649-016, Lisbon, Portugal; ToxOmics, NMS, NOVA University of Lisbon, Lisbon, Portugal

700    1_

$a Sirota, Nikolay $u Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Institutskaya 3, Pushchino, Moscow Region, Russia

700    1_

$a Smolkova, Bozena $u Cancer Research Institute, Biomedical Research Center of the Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovakia

700    1_

$a Staruchova, Marta $u Institute of Biology, Medical Faculty, Slovak Medical University, Limbova 12, 83303, Bratislava, Slovakia

700    1_

$a Stetina, Rudolf $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic

700    1_

$a Stopper, Helga $u Institute of Pharmacology and Toxicology, University of Wuerzburg, VersbacherStrasse 9, 97078, Wuerzburg, Germany

700    1_

$a Surikova, Ekaterina I $u Laboratory for the Study of the Pathogenesis of Malignant Tumors, National Medical Research Center for Oncology, 14 line 63, 344037, Rostov-on-Don, Russia

700    1_

$a Ulven, Stine M $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway

700    1_

$a Ursini, Cinzia Lucia $u Department of Occupational and Environmental Medicine, Epidemiology and Hygiene (DiMEILA), Italian Workers' Compensation Authority (INAIL), Via Fontana Candida 1, 00078, Monte Porzio Catone(Rome), Italy

700    1_

$a Valdiglesias, Vanessa $u Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Biología, Facultad de Ciencias, Universidade da Coruña, Campus A Zapateira s/n, 15071, A Coruña, Spain

700    1_

$a Valverde, Mahara $u Genomic Medicine and EnvironmentalToxicology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, CU, Mexico

700    1_

$a Vodicka, Pavel $u Experimental Medicine, Molecular Biology of Cancer, IEM AVCR, Videnska 1083, Prague 4, Prague, Czech Republic

700    1_

$a Volkovova, Katarina $u Institute of Biology, Medical Faculty, Slovak Medical University, Limbova 12, 83303, Bratislava, Slovakia

700    1_

$a Wagner, Karl-Heinz $u Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria

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$a Dušinská, Maria $u NILU, Health Effects Laboratory, Kjeller, Norway

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$a Bonassi, Stefano $u IRCCS San Raffaele Pisana, Unit of Clinical and Molecular Epidemiology, Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Via di Val Cannuta, 247., 00161, Rome, Italy. Electronic address: stefano.bonassi@sanraffaele.it

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