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Role of Sodium/Calcium Exchangers in Tumors

B. Chovancova, V. Liskova, P. Babula, O. Krizanova

. 2020 ; 10 (9) : . [pub] 20200831

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026611

Grantová podpora
APVV-16-0246 Agentúra na Podporu Výskumu a Vývoja - International
VEGA 2/0038/19. Vedecká Grantová Agentúra MŠVVaŠ SR a SAV - International

The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted-calcium ions are transported inside the cell and sodium ions are transported out of the cell. To date, three isoforms of the NCX have been identified and characterized in humans. Majority of information about the NCX function comes from isoform 1 (NCX1). Although knowledge about NCX function has evolved rapidly in recent years, little is known about these transport systems in cancer cells. This review aims to summarize current knowledge about NCX functions in individual types of cancer cells.

Citace poskytuje Crossref.org

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