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In vitro evaluation of a novel nanostructured Ti-36Nb-6Ta alloy for orthopedic applications
B. Voltrova, P. Jarolimova, V. Hybasek, VH. Blahnova, J. Sepitka, V. Sovkova, R. Matějka, M. Daniel, J. Fojt, E. Filova
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
PubMed Central
from 2015 to 1 year ago
ProQuest Central
from 2006-06-01 to 2021-01-31
Health & Medicine (ProQuest)
from 2006-06-01 to 2021-01-31
PubMed
32752935
DOI
10.2217/nnm-2020-0123
Knihovny.cz E-resources
- MeSH
- Cell Adhesion MeSH
- Humans MeSH
- Microscopy, Electron, Scanning MeSH
- Nanotubes * MeSH
- Osteoblasts MeSH
- Osteogenesis MeSH
- Surface Properties MeSH
- Cell Proliferation MeSH
- Alloys MeSH
- Titanium * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Aim: To evaluate the impact of a nanostructured surface created on β-titanium alloy, Ti-36Nb-6Ta, on the growth and differentiation of human mesenchymal stem cells. Materials & methods: The nanotubes, with average diameters 18, 36 and 46 nm, were prepared by anodic oxidation. Morphology, hydrophilicity and mechanical properties of the nanotube layers were characterized. The biocompatibility and osteogenic potential of the nanostructured surfaces were established using various in vitro assays, scanning electron microscopy and confocal microscopy. Results: The nanotubes lowered elastic modulus close to that of bone, positively influenced cell adhesion, improved ALP activity, synthesis of type I collagen and osteocalcin expression, but diminished early cell proliferation. Conclusion: Nanostructured Ti-36Nb-6Ta with nanotube diameters 36 nm was the most promising material for bone implantation.
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- $a Voltrova, Barbora $u Department of Tissue Engineering, Institute of Experimental Medicine of The Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague, Czech Republic $u Department of Physiology, Faculty of Science, Charles University in Prague, Albertov 2038/6, 128 00, Prague, Czech Republic
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- $a Aim: To evaluate the impact of a nanostructured surface created on β-titanium alloy, Ti-36Nb-6Ta, on the growth and differentiation of human mesenchymal stem cells. Materials & methods: The nanotubes, with average diameters 18, 36 and 46 nm, were prepared by anodic oxidation. Morphology, hydrophilicity and mechanical properties of the nanotube layers were characterized. The biocompatibility and osteogenic potential of the nanostructured surfaces were established using various in vitro assays, scanning electron microscopy and confocal microscopy. Results: The nanotubes lowered elastic modulus close to that of bone, positively influenced cell adhesion, improved ALP activity, synthesis of type I collagen and osteocalcin expression, but diminished early cell proliferation. Conclusion: Nanostructured Ti-36Nb-6Ta with nanotube diameters 36 nm was the most promising material for bone implantation.
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- $a Jarolimova, Petra $u Department of Metals & Corrosion Engineering, University of Chemistry & Technology, Technická 5, 166 29, Prague, Czech Republic
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- $a Matějka, Roman $u Faculty of Biomedical Engineering, Czech Technical University in Prague, Náměstí Sítná 3105, 272 01, Kladno, Czech Republic
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