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Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al
HV. Olesen, P. Drevinek, VA. Gulmans, E. Hatziagorou, A. Jung, M. Mei-Zahav, N. Stojnic, M. Thomas, A. Zolin, ECFSPR Steering Group
Language English Country Netherlands
Document type Journal Article
- MeSH
- Cystic Fibrosis * complications diagnosis epidemiology genetics MeSH
- Diabetes Mellitus * diagnosis epidemiology etiology MeSH
- Child MeSH
- Adult MeSH
- Exocrine Pancreatic Insufficiency * diagnosis epidemiology etiology MeSH
- Respiratory Tract Infections * epidemiology etiology microbiology MeSH
- Humans MeSH
- Mutation MeSH
- Nutritional Status MeSH
- Needs Assessment MeSH
- Prevalence MeSH
- Cystic Fibrosis Transmembrane Conductance Regulator genetics MeSH
- Respiratory Function Tests methods statistics & numerical data MeSH
- Risk Factors MeSH
- Sex Factors MeSH
- Age Factors MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Europe MeSH
BACKGROUND: Cystic fibrosis related diabetes (CFRD) has implications for morbidity and mortality with several risk factors identified. We studied the epidemiology of CFRD in the large dataset of the European Cystic Fibrosis Society Patient registry. METHODS: Data on CF patients were investigated for the prevalence of CFRD as well as for any association with suggested risk factors and effects. RESULTS: CFRD increased by approximately ten percentage points every decade from ten years of age. Prevalence was higher in females in the younger age groups. CFRD was associated with severe CF genotypes (OR = 3.11, 95%CI: 2.77-3.48), pancreatic insufficiency (OR = 1.46, 95%CI: 1.39-1.53) and female gender (OR = 1.28, 95%CI: 1.21-1.34). Patients with CFRD had higher odds of being chronically infected with Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia than patients without CFRD, higher odds of having FEV1% of predicted <40% (OR = 1.82, 95%CI: 1.70-1.94) and higher odds of having BMI SDS ≤-2 than patients without CFRD (OR = 1.24, 95%CI: 1.15-1.34). CONCLUSIONS: Severe genotype, pancreatic insufficiency and female gender remain considerable intrinsic risk factors for early acquisition of CFRD. CFRD is associated with infections, lower lung function and poor nutritional status. Early diagnosis and aggressive treatment of CFRD are more important than ever with increasing life span.
Belgian Cystic Fibrosis Registry Sciensano Belgium
Department of Clinical Sciences and Community Health University of Milan Milan Italy
Department of Pulmonology Mother and Child Healthcare Institute of Serbia Belgrade Serbia
Dept of Pediatrics and Adolescent Medicine Aarhus University Hospital Denmark
Dutch Cystic Fibrosis Foundation Baarn The Netherlands
Paediatric Pulmonology University Children`s Hospital Zurich Zurich Switzerland
References provided by Crossref.org
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- $a Olesen, Hanne V $u Dept of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Denmark. Electronic address: hvo@dadlnet.dk
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- $a Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al / $c HV. Olesen, P. Drevinek, VA. Gulmans, E. Hatziagorou, A. Jung, M. Mei-Zahav, N. Stojnic, M. Thomas, A. Zolin, ECFSPR Steering Group
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- $a BACKGROUND: Cystic fibrosis related diabetes (CFRD) has implications for morbidity and mortality with several risk factors identified. We studied the epidemiology of CFRD in the large dataset of the European Cystic Fibrosis Society Patient registry. METHODS: Data on CF patients were investigated for the prevalence of CFRD as well as for any association with suggested risk factors and effects. RESULTS: CFRD increased by approximately ten percentage points every decade from ten years of age. Prevalence was higher in females in the younger age groups. CFRD was associated with severe CF genotypes (OR = 3.11, 95%CI: 2.77-3.48), pancreatic insufficiency (OR = 1.46, 95%CI: 1.39-1.53) and female gender (OR = 1.28, 95%CI: 1.21-1.34). Patients with CFRD had higher odds of being chronically infected with Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia than patients without CFRD, higher odds of having FEV1% of predicted <40% (OR = 1.82, 95%CI: 1.70-1.94) and higher odds of having BMI SDS ≤-2 than patients without CFRD (OR = 1.24, 95%CI: 1.15-1.34). CONCLUSIONS: Severe genotype, pancreatic insufficiency and female gender remain considerable intrinsic risk factors for early acquisition of CFRD. CFRD is associated with infections, lower lung function and poor nutritional status. Early diagnosis and aggressive treatment of CFRD are more important than ever with increasing life span.
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- $a Drevinek, Pavel $u Department of Medical Microbiology, Motol University Hospital and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: pavel.drevinek@lfmotol.cuni.cz
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- $a Gulmans, Vincent A $u Dutch Cystic Fibrosis Foundation (NCFS), Baarn, The Netherlands. Electronic address: V.Gulmans@ncfs.nl
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- $a Mei-Zahav, Meir $u Pulmonary Institute, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Israel
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- $a Thomas, Muriel $u Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address: Muriel.thomas@sciensano.be
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- $a Zolin, Anna $u Belgian Cystic Fibrosis Registry, Sciensano, Belgium. Electronic address: anna.zolin@unimi.it
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