• MeSH
• Bromides therapeutic use   MeSH
• Pulmonary Disease, Chronic Obstructive * diagnosis   drug therapy   MeSH
• Dyspnea etiology   MeSH
• Formoterol Fumarate therapeutic use   MeSH
• Drug Therapy, Combination MeSH
• Middle Aged MeSH
• Humans MeSH
• Respiratory Function Tests statistics & numerical data   MeSH
• Treatment Outcome MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Publication type
• Case Reports MeSH

BACKGROUND: Cystic fibrosis related diabetes (CFRD) has implications for morbidity and mortality with several risk factors identified. We studied the epidemiology of CFRD in the large dataset of the European Cystic Fibrosis Society Patient registry. METHODS: Data on CF patients were investigated for the prevalence of CFRD as well as for any association with suggested risk factors and effects. RESULTS: CFRD increased by approximately ten percentage points every decade from ten years of age. Prevalence was higher in females in the younger age groups. CFRD was associated with severe CF genotypes (OR = 3.11, 95%CI: 2.77-3.48), pancreatic insufficiency (OR = 1.46, 95%CI: 1.39-1.53) and female gender (OR = 1.28, 95%CI: 1.21-1.34). Patients with CFRD had higher odds of being chronically infected with Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia than patients without CFRD, higher odds of having FEV1% of predicted <40% (OR = 1.82, 95%CI: 1.70-1.94) and higher odds of having BMI SDS ≤-2 than patients without CFRD (OR = 1.24, 95%CI: 1.15-1.34). CONCLUSIONS: Severe genotype, pancreatic insufficiency and female gender remain considerable intrinsic risk factors for early acquisition of CFRD. CFRD is associated with infections, lower lung function and poor nutritional status. Early diagnosis and aggressive treatment of CFRD are more important than ever with increasing life span.

• MeSH
• Cystic Fibrosis * complications   diagnosis   epidemiology   genetics   MeSH
• Diabetes Mellitus * diagnosis   epidemiology   etiology   MeSH
• Child MeSH
• Adult MeSH
• Exocrine Pancreatic Insufficiency * diagnosis   epidemiology   etiology   MeSH
• Respiratory Tract Infections * epidemiology   etiology   microbiology   MeSH
• Humans MeSH
• Mutation MeSH
• Nutritional Status MeSH
• Needs Assessment MeSH
• Prevalence MeSH
• Cystic Fibrosis Transmembrane Conductance Regulator genetics   MeSH
• Respiratory Function Tests methods   statistics & numerical data   MeSH
• Risk Factors MeSH
• Sex Factors MeSH
• Age Factors MeSH
• Check Tag
• Child MeSH
• Adult MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Europe MeSH

Objective. To improve pulmonary function, exercise capacity and quality of life of two women with Chronic Obstructive Pulmonary Disease (COPD). Material and Methods. Study of two clinical cases, both women. An intervention of 8 weeks was performed, in which the patients performed 3 weekly sessions, of which 1 was performed with supervision of the physiotherapist and 2 sessions were performed at home. The treatment sessions consisted of inspiratory muscle training with an inspiratory threshold and controlled breathing exercises with the pursed lip technique. Results. Quality of life of both women improved at the end of the study. In the woman with severe COPD, Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP) increased after the intervention. The Peak Expiratory Flow (PEF) improved in both cases, but not the rest of the spirometric values. Dyspnea improved in the woman with moderate COPD but not in the case of the one with severe COPD. Finally, the distance walked in the 6MWT improved in both cases. Conclusions. The training of the inspiratory muscles together with the pursed lip technique positively influences quality of life and exercise capacity of two women with COPD.

• MeSH
• Pulmonary Disease, Chronic Obstructive * rehabilitation   MeSH
• Breathing Exercises * methods   MeSH
• Respiratory Muscles MeSH
• Quality of Life MeSH
• Humans MeSH
• Respiratory Function Tests statistics & numerical data   MeSH
• Lip MeSH
• Aged MeSH
• Physical Therapy Modalities MeSH
• Treatment Outcome MeSH
• Check Tag
• Humans MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Clinical Study MeSH

• Keywords
• centrum komplexní péče, intervenční programy, MABC-2, kognitivní vývoj, socioemoční vývoj,
• MeSH
• Maternal-Child Health Centers * history   organization & administration   statistics & numerical data   MeSH
• Child MeSH
• Humans MeSH
• Interdisciplinary Communication MeSH
• Motor Skills MeSH
• Neurologic Examination methods   statistics & numerical data   MeSH
• Infant, Premature psychology   growth & development   MeSH
• Infant, Newborn MeSH
• Infant Care MeSH
• Birth Weight MeSH
• Psychological Tests statistics & numerical data   MeSH
• Respiratory Function Tests methods   statistics & numerical data   MeSH
• Research Design MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

• About
• Všeobecná fakultní nemocnice (Praha, Česko). Klinika pediatrie a dědičných poruch metabolismu. Centrum komplexní péče pro děti s perinatální zátěží Authority
• Univerzita Karlova. Lékařská fakulta, 1. Klinika pediatrie a dědičných poruch metabolismu. Centrum komplexní péče pro děti s perinatální zátěží Authority

OBJECTIVE: The association between energy metabolism and prognosis in polytrauma patients has not yet been defined. The aim of this study was to describe energy metabolism and analyze the prognostic value of respiratory quotient (RQ) and nonprotein respiratory quotient (npRQ) in fasting polytrauma patients (fPP) and polytrauma patients with nutritional support (nsPP). METHODS: Twenty-two polytrauma patients (before and after parenteral nutrition administration) and 22 healthy controls (after overnight fasting) were examined on day 4 (median) after admission to the intensive care unit. To evaluate energy expenditure in nsPP and resting energy expenditure in fPP and controls with RQ and npRQ in all groups, we used indirect calorimetry. With regression analysis, the descriptive models of intensive care unit (ICU) length of stay (LOS) and mechanical ventilation time (VT) were derived. RESULTS: RQ and npRQ were significantly lower in fPP than in controls (P < 0.05 and P < 0.01, respectively) and in nsPP (P < 0.05). In nsPP, relationships between RQ or npRQ and the ICU LOS or mechanical VT were demonstrated (P < 0.0001, r = -0.78 for RQ and VT; P < 0.0001, r = -0.78 for npRQ and VT; P < 0.001, r = -0.69 for RQ and LOS; P < 0.001, r = -0.72 for npRQ and LOS). CONCLUSIONS: RQ and npRQ parameters measured by indirect calorimetry in polytrauma patients with parenteral nutrition on the fourth day of ICU stay related to clinical outcomes such as duration of mechanical ventilation and ICU LOS.

• MeSH
• Basal Metabolism MeSH
• Time Factors MeSH
• Length of Stay statistics & numerical data   MeSH
• Adult MeSH
• Energy Metabolism MeSH
• Intensive Care Units MeSH
• Middle Aged MeSH
• Humans MeSH
• Calorimetry, Indirect methods   statistics & numerical data   MeSH
• Fasting MeSH
• Parenteral Nutrition statistics & numerical data   MeSH
• Pilot Projects MeSH
• Multiple Trauma physiopathology   therapy   MeSH
• Prognosis MeSH
• Prospective Studies MeSH
• Regression Analysis MeSH
• Respiratory Function Tests methods   statistics & numerical data   MeSH
• Respiration, Artificial statistics & numerical data   MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Observational Study MeSH
• Research Support, Non-U.S. Gov't MeSH

Liečba neinvazívnou ventiláciou (NIV) môže viesť k zníženiu mortality pacientov s obštrukčným spánkovým apnoe (OSA) a súčasne prítomnou chronickou obštrukčnou chorobou pľúc (CHOCHP). NIV s použitím dvojúrovňového pretlaku (BiPAP) je alternatívnou metódou v prípade intolerancie respektíve zlyhania liečby s kontinuálnym pretlakom v dýchacích cestách (continuous positive airway pressure,CPAP) a tiež pri respiračnej insuficiencii. Cieľom tejto štúdie bolo charakterizovať 67 pacientov s overlap syndrómom vyžadujúcich liečbu CPAP respektive BiPAP. V porovnaní s pacientmi liečenými efektívne s CPAP mali pacienti vyžadujúci použitie BiPAP závažnejšiu obštrukčnú ventilačnú poruchu (FEV1 46,4 ± 9,4 oproti 62,7 ± 15,2 %; p < 0,001), závažnejšiu hypoxémiu (PaO2 6,5 ± 1,3 oproti 8,3 ± 1,7 kPa; p = 0,002) a hyperkapniu (PaCO2 7,4 ± 0,7 oproti 5,9 ± 1,4 kPa; p < 0,001). Pacienti liečení s BiPAP mali počas diagnostického polysomnografického vyšetrenia vyšší desaturačný index (69,8 ± 32,2 oproti 41,4 ± 31,7/hod.; p = 0,005) ako aj dlhší čas desaturácie pod 90 % (356 ± 158 min oproti 160 ± 154 min; p < 0,001) ako pacienti liečení s CPAP. Liečba s CPAP a BiPAP efektívne znížila index apnoe-hypopnoe (AHI) pod 10/hodinu u všetkých pacientov. U pacientov s respiračnou insuficienciou liečených s BiPAP viedla táto liečba tiež k k efektívnemu zvýšeniu PaO2 (z 6,5± 1,3 na7,5 ± 1,4 kPa; p = 0,012) a k súčasnému zníženiu PaCO2 (z 7,4 ± 0,7 na 6,5 ± 1,0 kPa; p = 0,009).

Therapy with noninvasive ventilation (NIV) may improve survival in patients with obstructive sleep apnea (OSA) and concurrent chronic obstructive pulmonary disease (COPD). Bilevel positive airway pressure (BiPAP) ventilation is a treatment modality in patients with intoleremce or primary failure of continuous positive airway pressure (CPAP) or those with respiratory insufficiency. The aim was to evaluate treatment with NIV in 67 patients with the overlap syndrome. Patients were divided into two groups based on whether they required CPAP or BiPAP therapy. Compared to patients effectively treated with CPAP, those requiring BiPAP therapy had more severe obstructive ventilatory impairment (FEVi 46.4 ± 9.4 vs 62.7 ± 15.2 %; p < 0.001), more profound hypoxemia (Pa02 6.5 ±1.3 vs 8.3 ±1.7 kPa; p = 0.002) and hypercapnia (PaC02 7.4 ± 0.7 vs 5.9 ±1.4 kPa; p < 0.001). During a night study, they had a higher oxygen desaturation index (69.8 ± 32.2 vs 41.4 ± 31.7 per hour.; p = 0.005) and a longer time of desaturation below 90 % (356.0 ± 158.7 vs 160.1 ± 154.2 min; p < 0.001). Treatment with NIV effectively abolished OSA in both groups by reducing the apnea-hypopnea index below 10 events per hour. In patients with respiratory failure treated with BiPAP for a period of 5-7 days, Pa02 increased (from 6.5 ± 1.3 kPa to 7.5 ± 1.4 kPa; p = 0.012), and PaC02 was reduced (from 7.4 ± 0.7 kPa'to 6.5 ±1.0 kPa; p= 0.009).

• MeSH
• Pulmonary Disease, Chronic Obstructive * blood   therapy   MeSH
• Humans MeSH
• Sleep Apnea, Obstructive * blood   therapy   MeSH
• Polysomnography MeSH
• Respiratory Function Tests statistics & numerical data   MeSH
• Retrospective Studies MeSH
• Continuous Positive Airway Pressure * methods   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Clinical Study MeSH
• Research Support, Non-U.S. Gov't MeSH

Cieľ: Zistiť vzťahy medzi funkciou respiračných svalov objektivizovanej metódou merania oklúznych tlakov a klasickými funkčnými spirometrickými parametrami. Súbor: 51 pacientov spĺňajúci kritéria diagnózy silicosis pulmonum. Metodika: Parametre hodnotenia sily dýchacích svalov na základe hodnotenia oklúznych tlakov: ústny oklúzny tlak za 0,1 s inspíria (P0,1), respiračná kapacita (P0,1/PImax), parametre štandardného spirometrického vyšetrenia. Výsledky: Zistili sme signifikantné vzťahy medzi parametrami ústneho oklúzneho tlaku za 0,1 s inspíria (P0,1), respiračnou kapacitou (P0,1/PImax) a parametrami spirometrického vyšetrenia % VC , FEV1 a % FEV1. Záver: Na základe týchto zistení predpokladáme širšie využitie metódy merania oklúznych tlakov vo všetkých oblastiach medicíny, kde je potrebná objektivizácia funkcie respiračných svalov, vrátane rehabilitačnej medicíny. Kľúčové slová: ústny oklúzny tlak, funkčné vyšetrenie pľúc, pľúcna rehabilitácia

Objective: To assess the relationship between respiratory muscle function the occlusion pressure measuring and standard functional spirometric parameters. Group of patients: Fifty one patients fulfilling the criteria for the diagnosis of pulmonary silicosis. Methods: The evaluation of respiratory muscle strength based on occlusion the pressure measurement. Mouth occlusion pressure at 0.1 s inspiration (P0.1), respiratory capacity (P0.1 /Pimax) and standard spirometric parameters has been measured. Results: We found significant relationships between parameters of mouth occlusion pressure 0.1 s after the onset of inspiration (P0.1), respiratory capacity (P0.1/PImax) and spirometric parameters such as % VC, FEV1 and FEV1%. Conclusion: Based on our findings we suggest a wider use of measurement the occlusion pressure in all areas of clinical medicine where it is needed the objectification of respiratory muscles function including rehabilitation medicine. Keywords: mouth occlusion pressure, pulmonary function tests, pulmonary rehabilitation

• Keywords
• ústní okluzní tlak dýchacích svalů,
• MeSH
• Respiratory Muscles * physiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Statistics, Nonparametric MeSH
• Pulmonary Ventilation physiology   MeSH
• Respiratory Function Tests * methods   statistics & numerical data   MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Silicosis diagnosis   MeSH
• Spirometry statistics & numerical data   MeSH
• Mouth * MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Aged, 80 and over MeSH
• Aged MeSH

Cílem této práce bylo ověřit vliv účinku přípravku Ventolin InhalerNna vytrvalostní výkon u sportovců bez diagnózy astmatu. Výzkumný soubor tvořili výkonnostní běžci – muži (n = 16, věk 25,94 ± 3,54 roků; výška 183,09 ± 5,05 cm; hmotnost 79,29 ± 7,88 kg). V rámci studie jsme zkoumali parametry klidové spirometrie (FVC, FEV1) a spiroergometrie zátěžového testu submaximálního a maximálního úsilí (spotřeba kyslíku, plicní ventilace, RER, srdeční frekvence, rychlost na anaerobním prahu a maximální dosažená rychlost) na běžeckém pásu. Pro design výzkumu jsme použili plán s křížovou klasifikací a opakováním měření. Pro hodnocení statistické významnosti rozdílů jsme použili párový t-test pro dva závislé soubory. Statistickou významnost jsme hodnotili na hladině 0,05, resp. 0,01. Pro zpracování dat byl použit software SPSS PASW Statistics 18. Studie ukázala, že Ventolin Inhaler N má statisticky významný vliv na výkon u sportovců bez diagnózy astmatu jak v oblasti klidové spirometrie měřené před zátěžovým testem (FEV1 p = 0,001; FVC p = 0,026), tak po testu (FEV1 p = 0,020). V oblasti submaximálního zatížení (rychlost 13 km.h-1) jsme nalezli signifikantní rozdíly u parametru spotřeby kyslíku (p = 0,005) plicní ventilace (p = 0,009) a respiračního kvocientu (p = 0,015). V oblasti maximálního zatížení jsme nalezli signifikantní rozdíly u parametru spotřeby kyslíku (p = 0,009) plicní ventilace (p = 0,0015) a respiračního kvocientu (p = 0,001). Zároveň jsme prokázali zvýšení rychlosti na úrovni individuálního anaerobního prahu (p = 0,005). Z nepříznivých účinků jsme statisticky významný rozdíl nalezli pouze u výskytu křečí (p = 0,043).

The aim of this study was to verify the influence of the effect of Ventolin Inhaler N on endurance performance in athletes without asthma diagnosis. The sample included a performance runners – men ( n = 16 , age 25.94 ± 3.54 years , height 183.09 ± 5.05 cm , weight 79.29 ± 7.88 kg). We investigated the effect of resting spirometric parameters (FVC, FEV1) and spiroergometry test submaximum and maximum load (oxygen uptake, ventilation, RER, heart rate, speed at the anaerobic threshold and maximum speed achieved) on the treadmill. For design research, we used a plan with cross-classification and repeating the measurement. To evaluate the statistical significance of differences, we used paired t-test for two dependent files. Statistical significance was evaluated on level 0.05 respectively 0.01. For data processing software was used SPSS PASW Statistics 18. The study showed that Ventolin Inhaler N has a statistically significant effect on performance in athletes without a diagnosis of asthma in both resting spirometry measured before the test (FEV1, p = 0.001; FVC, p = 0.026) and after test (FEV1 p = 0.020). In submaximal load (speed 13 km.h-1), we found significant differences in parameter of oxygen uptake (p = 0.005) ventilation (p = 0.009) and respiratory quotient (p = 0.015). In the area of maximum load, we found significant differences in parameter of oxygen uptake (p = 0.009), ventilation (p = 0.0015) and respiratory quotient (p = 0.001). We have also demonstrated an increase in speed at the individual anaerobic threshold (p = 0.005). The negative effects are statistically significant difference found only in the incidence of cramps (p = 0.043).

• Keywords
• salbutamol, plicní funkce, spiroergometrie,
• MeSH
• Albuterol * administration & dosage   adverse effects   MeSH
• Anaerobic Threshold drug effects   MeSH
• Anti-Asthmatic Agents administration & dosage   MeSH
• Running * MeSH
• Asthma MeSH
• Exercise MeSH
• Doping in Sports MeSH
• Adult MeSH
• Ergometry MeSH
• Performance-Enhancing Substances * MeSH
• Humans MeSH
• Young Adult MeSH
• Respiratory Function Tests statistics & numerical data   MeSH
• Spirometry MeSH
• Oxygen Consumption drug effects   MeSH
• Statistics as Topic MeSH
• Physical Exertion drug effects   MeSH
• Physical Fitness MeSH
• Forced Expiratory Volume drug effects   MeSH
• Seizures chemically induced   MeSH
• Exercise Test statistics & numerical data   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Young Adult MeSH
• Male MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

Úvod: Inhibitory fosfodiesterázy 5 (IPDE5) v experimentu obnovují chloridový transport na buňkách epitelií dýchacích cest u cystické fibrózy (CF) s mutací F508del. Nemocní s CF s těžkým plicním onemocněním jsou v riziku zhoršené tolerance námahy. Léčba pomocí IPDE5 je u CF slibnou strategií. Metodika: Do studie bylo zařazeno 12 dospělých nemocných s CF, homozygotů F508del bez kolonizace komplexem Burkholderia cepacia, s mediánem (IQR) věku 25,9 (22,8-27,6) roku. Nemocným byl podáván sildenafil po dobu 30 dnů. Před a po léčbě byly vyšetřeny plicní funkce (usilovně vydechnutý objem za první sekundu /FEV1/, test šestiminutovou chůzí /ušlá vzdálenost za 6 minut; 6-MWD/ a dotazník kvality života (CFQ-R), kde bylo hodnoceno skóre respirační domény (RESP) a domény fyzické aktivity (PHYS). Výsledky: Studii dokončilo 8 pacientů (důvodem ukončení byla u dvou plicní exacerbace a u dalších dvou bolesti hlavy). Došlo k signifikantnímu zlepšení tolerance námahy v parametru (medián a IQR) 6-MWD 618 (612-692) vs. 577 (562-633) m, p=0,012, a PHYS 93,8 (68,8-100,0) vs. 89,6 (60,4-97,9), p=0,043. Plicní funkce a skóre RESP se významně nezměnily. Závěr: Krátkodobá léčba sildenafilem vedla u F508del homozygotních dospělých nemocných s CF ke zlepšení tolerance námahy, a to bez ovlivnění plicních funkcí a respiračních symptomů.

Introduction: Phosphodiesterase type 5 inhibitors (PDE5) are able to restore chloride transport in the F508del cystic fibrosis (CF) airway epithelium. CF patients with severe lung disease are at risk of impaired exercise toleranee. Treatment with PDE5 is a promising strategy in CF. Methods: Twelve stable F508del homozygous CF adults witii a median (IQR) age of 25.9 (range, 22.8-27.6) years without Burkholderia cepacia complex airway colonization were included in the study. The patients were administered sildenafil for 30 days. Their pulmonary function, respiratory symptoms and exercise tolerance were assessed before and after treatment using spirometry (forced expiratory volume in 1st second (FEV1), a 6-minute walk test (6-minute walking distance 16MWD1) and tiie CFQ-R quality of life questionnaire (physical and respiratory domains (PHYS and RESP, respectively]). Results: Eight patients completed the study (2 dropped out due to pulmonary exacerbations and another 2 due to headaches). Exercise tolerance changed significantly in the following parameters (median and IQR): 6MWD 618 m (range, 612-692 m) vs. 577 m (range, 562-633 m), p = 0.012. and PHYS 93.8 (range, 68.8-100.0) vs. 89.6 (range, 60.4-97.9), p = 0.043, whereas pulmonary function and respiratory symptoms did not. Conclusions: Short-term sildenafil treatment in F508del homozygous CF adults led to improved exercise toleranee without changes in pulmonary function and respiratory symptoms

• MeSH
• Cystic Fibrosis * drug therapy   complications   MeSH
• Adult * MeSH
• Phosphodiesterase Inhibitors * administration & dosage   pharmacology   adverse effects   therapeutic use   MeSH
• Quality of Life MeSH
• Humans MeSH
• Surveys and Questionnaires MeSH
• Respiratory Function Tests methods   statistics & numerical data   MeSH
• Statistics as Topic MeSH
• Efficiency physiology   drug effects   MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult * MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

Úvod: Sarkoidóza je systémové granulomatózní onemocnění, které se velmi často projevuje ve formě klinicky limitované pouze na plíce. Cílem této studie bylo srovnat klinické a laboratorní parametry mezi pacienty s onemocněním limitovaným na nitrohrudní orgány a mimoplicní formou sarkoidózy. Metodika: Do studie jsme zařadili 161 pacientů hospitalizovaných na Klinice plicních nemocí a TBC ve FN Olomouc v letech 2007–2011 s nově diagnostikovanou sarkoidózou. U 107 pacientů bylo diagnostikováno onemocnění limitované na nitrohrudní orgány, u 54 bylo zjištěno generalizované (plicní i mimoplicní) postižení. V tomto souboru jsme srovnali vybrané klinické a laboratorní ukazatele: věk při stanovení diagnózy, pohlaví, kouření, krevní obraz, skiagram hrudníku a funkční vyšetření plic. Byl sledován výskyt hyperkalcinémie, hyperkalciurie, sérové hladiny CRP, sérového angiotensin konvertujícího enzymu (SACE), solubilního receptoru pro interleukin 2 (sIL-2R) a neopterinu. Dále byl srovnán buněčný profil a poměr CD4+/CD8+ v bronchoalveolární lavážní tekutině (BALTe). Subanalýza byla provedena u skupiny mužů a žen. Výsledky: Pacienti s generalizovanou sarkoidózou byli starší, převažovali nekuřáci ve srovnání s pacienty s limitovanou formou. Mezi oběma skupinami nebyl shledán rozdíl ve funkčních parametrech, hodnotách krevního obrazu ani sérových koncentrací CRP, SACE, sIL-2R a neopterinu. Absolutní ani relativní počty alveolárních makrofágů, lymfocytů, neutrofilů a eozinofilů se nelišily mezi nemocnými s limitovanou a generalizovanou formou onemocnění, a to ani při rozdělení na muže a ženy. U žen s limitovanou formou sarkoidózy byl zjištěn vyšší počet trombocytů v krevním obraze a vyšší hodnoty funkčního parametru VC a FEV1 než u žen s generalizovaným onemocněním. Dále bylo zjištěno vyšší zastoupení CD19+ lymfocytů v BALTe žen s limitovaným onemocněním než u pacientek s generalizovanou formou. U podskupiny mužů nebyl zjištěn žádný rozdíl ve studovaných parametrech mezi sarkoidózou limitovanou na plíce a generalizovanou formou. Závěr: S výjimkou rozdílu věku, ventilačních parametrů a zastoupení CD19+ lymfocytů v BALTe u žen neukázal žádný studovaný parametr vztah k rozsahu onemocnění, a není tudíž využitelný k predikci míry systémového postižení u sarkoidózy.

Background: Sarcoidosis is a systemic granulomatous disease frequentiy manifested in the form clinically limited to the lungs. The objective was to compare the clinical and laboratory parameters between patients with the disease limited to the intiathoracic organs and those with extiapulmonary sarcoidosis. Methods: The study comprised 161 patients hospitalized for newly diagnosed sarcoidosis at the Department of Respiratory Medicine, University Hospital Olomouc in 2007-2011. Of those, a total of 107 patients were diagnosed with the disease limited to the intiathoracic organs and 54 with generalized (both pulmonary and extiapulmonary involvement). The following clinical and laboratory parameters were compared: age at diagnosis gender, smoking status, blood count, chest radiograph and pulmonary function. Further, hypercalcinemia, hypercalciuria, serum CRP, serum angiotensin-converting enzyme (SACE), soluble interleukin-2 receptor (sIL-2R) and neopterin levels were analyzed. Finally, the cell profile and CD4+/CD8+ ratio in the bronchoalveolar lavage (BAL) fluid were compared. Subanalyses were carried out in male and female subgroups. Results: Patients with generalized sarcoidosis were older, mostiy non-smokers, as compared with those with the limited form. Between the two groups, there were no differences in functional parameters, blood count values or serum concentiations of CRP, SACE, sIL-2R and neopterin. There were no differences in both absolute and negative counts of alveolar macrophages, lymphocytes, neutiophils and eosinophils between patients with limited and generalized sarcoidosis, even after males and females being studied separately. Females with limited sarcoidosis were found to have higher platelet count and higher VC and FEVl values than those with the generalized form. Also, there was a higher proportion of CD 19+ cells in the BAL fluid of women with the limited disease than in those with generalized sarcoidosis. In the male subgroup, there were no differences in the studied parameters between sarcoidosis limited to the lungs and the generalized form. Conclusions: With the exceptions of age, ventilation parameters and the proportion of CD 19+ cells in the BAL fluid in females, none of the studied parameters were found to be related to the extent of the disease, and thus cannot be used to predict the level of systemic involvement in sarcoidosis.

• Keywords
• limitovaná sarkoidóza, generalizovaná sarkoidóza, klinické parametry, laboratorní parametry,
• MeSH
• Antigens, CD19 MeSH
• Bronchoalveolar Lavage Fluid cytology   immunology   MeSH
• C-Reactive Protein MeSH
• Adult MeSH
• Clinical Laboratory Techniques * statistics & numerical data   MeSH
• Smoking MeSH
• Blood Cell Count statistics & numerical data   MeSH
• Middle Aged MeSH
• Humans MeSH
• Sarcoidosis, Pulmonary * diagnosis   blood   MeSH
• Radiography, Thoracic * statistics & numerical data   MeSH
• Respiratory Function Tests statistics & numerical data   MeSH
• Retrospective Studies MeSH
• Sarcoidosis * diagnosis   blood   MeSH
• Statistics as Topic MeSH
• Age Distribution MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Comparative Study MeSH