Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

SNPs within CHRNA5-A3-B4 and CYP2A6/B6, nicotine metabolite concentrations and nicotine dependence treatment success in smokers

J. A. Hubacek, I. Kurcova, V. Maresova, A. Pankova, L. Stepankova, K. Zvolska, V. Lanska, E. Kralikova

. 2021 ; 165 (1) : 84-89. [pub] 20191129

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21028028

AIM: Plasma values of nicotine and its metabolites are highly variable, and this variability has a strong genetic influence. In our study, we analysed the impact of common polymorphisms associated with smoking on the plasma values of nicotine, nicotine metabolites and their ratios and investigated the potential effect of these polymorphisms and nicotine metabolite ratios on the successful treatment of tobacco dependence. METHODS: Five variants (rs16969968, rs6474412, rs578776, rs4105144 and rs3733829) were genotyped in a group of highly dependent adult smokers (n=103). All smokers underwent intensive treatment for tobacco dependence; 33 smokers were still abstinent at the 12-month follow-up. RESULTS: The rs4105144 (CYP2A6, P<0.005) and rs3733829 (EGLN2, P<0.05) variants were significantly associated with plasma concentrations of 3OH-cotinine and with 3OH-cotinine: cotinine ratios. Similarly, the unweighted gene score was a significant (P<0.05) predictor of both cotinine:nicotine and 3OH-cotinine:cotinine ratios. No associations between the analysed polymorphisms or nicotine metabolite ratios and nicotine abstinence rate were observed. CONCLUSION: Although CYP2A6 and EGLN2 polymorphisms were associated with nicotine metabolism ratios, neither these polymorphisms nor the ratios were associated with abstinence rates.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc21028028
003      
CZ-PrNML
005      
20211129142953.0
007      
ta
008      
211105s2021 xr f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2019.058 $2 doi
035    __
$a (PubMed)31796940
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Hubáček, Jaroslav, $d 1966- $7 nlk20050169367 $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
245    10
$a SNPs within CHRNA5-A3-B4 and CYP2A6/B6, nicotine metabolite concentrations and nicotine dependence treatment success in smokers / $c J. A. Hubacek, I. Kurcova, V. Maresova, A. Pankova, L. Stepankova, K. Zvolska, V. Lanska, E. Kralikova
504    __
$a Literatura
520    9_
$a AIM: Plasma values of nicotine and its metabolites are highly variable, and this variability has a strong genetic influence. In our study, we analysed the impact of common polymorphisms associated with smoking on the plasma values of nicotine, nicotine metabolites and their ratios and investigated the potential effect of these polymorphisms and nicotine metabolite ratios on the successful treatment of tobacco dependence. METHODS: Five variants (rs16969968, rs6474412, rs578776, rs4105144 and rs3733829) were genotyped in a group of highly dependent adult smokers (n=103). All smokers underwent intensive treatment for tobacco dependence; 33 smokers were still abstinent at the 12-month follow-up. RESULTS: The rs4105144 (CYP2A6, P<0.005) and rs3733829 (EGLN2, P<0.05) variants were significantly associated with plasma concentrations of 3OH-cotinine and with 3OH-cotinine: cotinine ratios. Similarly, the unweighted gene score was a significant (P<0.05) predictor of both cotinine:nicotine and 3OH-cotinine:cotinine ratios. No associations between the analysed polymorphisms or nicotine metabolite ratios and nicotine abstinence rate were observed. CONCLUSION: Although CYP2A6 and EGLN2 polymorphisms were associated with nicotine metabolism ratios, neither these polymorphisms nor the ratios were associated with abstinence rates.
650    _2
$a dospělí $7 D000328
650    _2
$a cytochrom P450 CYP2A6 $x genetika $7 D065637
650    _2
$a cytochrom P450 CYP2B6 $x genetika $7 D065702
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a proteiny nervové tkáně $x genetika $7 D009419
650    _2
$a nikotin $x krev $x metabolismus $7 D009538
650    12
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a nikotinové receptory $x genetika $7 D011978
650    _2
$a poruchy vyvolané užíváním tabáku $x krev $x genetika $x metabolismus $x terapie $7 D014029
650    _2
$a výsledek terapie $7 D016896
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kurcová, Ivana $7 xx0108673 $u Department of Toxicology and Forensic Medicine, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
700    1_
$a Marešová, Věra, $d 1955- $7 jo2003163134 $u Department of Toxicology and Forensic Medicine, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
700    1_
$a Pánková, Alexandra $7 xx0195009 $u Centre for Tobacco-Dependent, 3rd Department of Medicine - Department of Endocrinology and Metabolism, 1st Faculty of Medicine, Charles University and the General University Hospital in Prague, Czech Republic $u Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University and the General University Hospital in Prague, Czech Republic
700    1_
$a Štěpánková, Lenka $7 xx0159606 $u Centre for Tobacco-Dependent, 3rd Department of Medicine - Department of Endocrinology and Metabolism, 1st Faculty of Medicine, Charles University and the General University Hospital in Prague, Czech Republic
700    1_
$a Zvolská, Kamila, $d 1980- $7 xx0214179 $u Centre for Tobacco-Dependent, 3rd Department of Medicine - Department of Endocrinology and Metabolism, 1st Faculty of Medicine, Charles University and the General University Hospital in Prague, Czech Republic
700    1_
$a Lánská, Věra $7 xx0062305 $u Statistical Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Králíková, Eva, $d 1956- $7 jn20000401512 $u Centre for Tobacco-Dependent, 3rd Department of Medicine - Department of Endocrinology and Metabolism, 1st Faculty of Medicine, Charles University and the General University Hospital in Prague, Czech Republic $u Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University and the General University Hospital in Prague, Czech Republic
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia $x 1213-8118 $g Roč. 165, č. 1 (2021), s. 84-89
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31796940 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y p $z 0
990    __
$a 20211105 $b ABA008
991    __
$a 20211116103722 $b ABA008
999    __
$a ok $b bmc $g 1728690 $s 1148573
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 165 $c 1 $d 84-89 $e 20191129 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20211105

Find record

Citation metrics

Archiving options