-
Je něco špatně v tomto záznamu ?
Effect of methylprednisolone on experimental brain edema in magnetic resonance imaging
P. Kozler, V. Herynek, D. Marešová, P. D. Perez, L. Šefc, J. Pokorný
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Free Medical Journals od 1998
PubMed Central od 2020
ProQuest Central od 2005-01-01
Medline Complete (EBSCOhost) od 2006-01-01
Nursing & Allied Health Database (ProQuest) od 2005-01-01
Health & Medicine (ProQuest) od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources od 1998
Odkazy
PubMed
32901489
DOI
10.33549/physiolres.934460
Knihovny.cz E-zdroje
- MeSH
- antiflogistika farmakologie MeSH
- edém mozku diagnostické zobrazování farmakoterapie patologie MeSH
- hipokampus diagnostické zobrazování účinky léků MeSH
- krysa rodu rattus MeSH
- magnetická rezonanční tomografie metody MeSH
- methylprednisolon farmakologie MeSH
- modely nemocí na zvířatech MeSH
- mozek diagnostické zobrazování účinky léků MeSH
- mozková kůra diagnostické zobrazování účinky léků MeSH
- potkani Wistar MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Magnetic resonance imaging has been used for evaluating of a brain edema in experimental animals to assess cytotoxic and vasogenic edema by the apparent diffusion coefficient (ADC) and T2 imaging. This paper brings information about the effectiveness of methylprednisolone (MP) on experimental brain edema. A total of 24 rats were divided into three groups of 8 animals each. Rats with cytotoxic/intracellular brain edema induced by water intoxication were assigned to the group WI. These rats also served as the additional control group CG when measured before the induction of edema. A third group (WIMP) was intraperitoneally administered with methylprednisolone 100 mg/kg during water intoxication treatment. The group WI+MP was injected with methylprednisolone 50 mg/kg into the carotid artery within two hours after the water intoxication treatment. We evaluated the results in four groups. Two control groups (CG, WI) and two experimental groups (WIMP, WI+MP). Rats were subjected to MR scanning 24 h after edema induction. We observed significantly increased ADC values in group WI in both evaluated areas - cortex and hippocampus, which proved the occurrence of experimental vasogenic edema, while ADC values in groups WIMP and WI+MP were not increased, indicating that the experimental edema was not developed and thus confirming the protective effect of MP.
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21028136
- 003
- CZ-PrNML
- 005
- 20211129135920.0
- 007
- ta
- 008
- 211105s2020 xr ad f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.934460 $2 doi
- 035 __
- $a (PubMed)32901489
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Kozler, Petr, $d 1951- $7 xx0057889 $u Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 245 10
- $a Effect of methylprednisolone on experimental brain edema in magnetic resonance imaging / $c P. Kozler, V. Herynek, D. Marešová, P. D. Perez, L. Šefc, J. Pokorný
- 504 __
- $a Literatura
- 520 9_
- $a Magnetic resonance imaging has been used for evaluating of a brain edema in experimental animals to assess cytotoxic and vasogenic edema by the apparent diffusion coefficient (ADC) and T2 imaging. This paper brings information about the effectiveness of methylprednisolone (MP) on experimental brain edema. A total of 24 rats were divided into three groups of 8 animals each. Rats with cytotoxic/intracellular brain edema induced by water intoxication were assigned to the group WI. These rats also served as the additional control group CG when measured before the induction of edema. A third group (WIMP) was intraperitoneally administered with methylprednisolone 100 mg/kg during water intoxication treatment. The group WI+MP was injected with methylprednisolone 50 mg/kg into the carotid artery within two hours after the water intoxication treatment. We evaluated the results in four groups. Two control groups (CG, WI) and two experimental groups (WIMP, WI+MP). Rats were subjected to MR scanning 24 h after edema induction. We observed significantly increased ADC values in group WI in both evaluated areas - cortex and hippocampus, which proved the occurrence of experimental vasogenic edema, while ADC values in groups WIMP and WI+MP were not increased, indicating that the experimental edema was not developed and thus confirming the protective effect of MP.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a antiflogistika $x farmakologie $7 D000893
- 650 _2
- $a mozek $x diagnostické zobrazování $x účinky léků $7 D001921
- 650 _2
- $a edém mozku $x diagnostické zobrazování $x farmakoterapie $x patologie $7 D001929
- 650 _2
- $a mozková kůra $x diagnostické zobrazování $x účinky léků $7 D002540
- 650 _2
- $a modely nemocí na zvířatech $7 D004195
- 650 _2
- $a hipokampus $x diagnostické zobrazování $x účinky léků $7 D006624
- 650 _2
- $a magnetická rezonanční tomografie $x metody $7 D008279
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a methylprednisolon $x farmakologie $7 D008775
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 _2
- $a potkani Wistar $7 D017208
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Herynek, Vít, $d 1967- $7 xx0069420 $u Center for Advanced Preclinical Imaging, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Marešová, Dana, $d 1946- $7 jn20000710437 $u Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Perez, Pablo D. $7 _AN112328 $u Center for Advanced Preclinical Imaging, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Šefc, Luděk, $d 1960- $7 xx0092587 $u Center for Advanced Preclinical Imaging, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Pokorný, Jaroslav, $d 1945- $7 jn20000710480 $u Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 773 0_
- $w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 69, č. 5 (2020), s. 919-926
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32901489 $y Pubmed
- 910 __
- $a ABA008 $b A 4120 $c 266 $y p $z 0
- 990 __
- $a 20211105 $b ABA008
- 991 __
- $a 20211122155248 $b ABA008
- 999 __
- $a ok $b bmc $g 1728745 $s 1148681
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 69 $c 5 $d 919-926 $e 20200909 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- LZP __
- $b NLK118 $a Pubmed-20211105