Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Comparison of pancreatic microcirculation profiles in spontaneously hypertensive rats and Wistar-kyoto rats by laser doppler and wavelet transform analysis

X. Song, Y. Li, B. Wang, M. Liu, J. Zhang, A. Li, H. Zhang, R. Xiu

. 2020 ; 69 (6) : 1039-1049. [pub] 20201102

Jazyk angličtina Země Česko

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21028149

Pancreatic microcirculatory dysfunction emerged as a novel mechanism in the development of hypertension. However, the changes of pancreatic microcirculation profiles in hypertension remain unknown. Pancreatic microcirculatory blood distribution pattern and microvascular vasomotion of spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) were determined by laser Doppler. Wavelet transform analysis was performed to convert micro-hemodynamic signals into time-frequency domains, based on which amplitude spectral scalograms were constructed. The amplitudes of characteristic oscillators were compared between SHRs and WKYs. The expression of eNOS was determined by immunohistochemistry, and plasma nitrite/nitrate levels were measured by Griess reaction. Additionally, endothelin-1, malondialdehyde, superoxide dismutase and interleukin-6 were determined by enzyme-linked immunosorbent assay. SHRs exhibited a lower scale blood distribution pattern with decreased average blood perfusion, frequency and amplitude. Wavelet transform spectral analysis revealed significantly reduced amplitudes of endothelial oscillators. Besides reduced expression of eNOS, the blood microcirculatory chemistry complements micro-hemodynamic profiles as demonstrated by an increase in plasma nitrite/nitrate, endothelin-1, malondialdehyde, interleukin-6 and a decrease of superoxide dismutase in SHRs. Here, we described abnormal pancreatic microcirculation profiles in SHRs, including disarranged blood distribution pattern, impaired microvascular vasomotion and reduced amplitudes of endothelial oscillators.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc21028149
003      
CZ-PrNML
005      
20211129135917.0
007      
ta
008      
211105s2020 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934448 $2 doi
035    __
$a (PubMed)33129246
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Song, Xiaohong $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
245    10
$a Comparison of pancreatic microcirculation profiles in spontaneously hypertensive rats and Wistar-kyoto rats by laser doppler and wavelet transform analysis / $c X. Song, Y. Li, B. Wang, M. Liu, J. Zhang, A. Li, H. Zhang, R. Xiu
504    __
$a Literatura
520    9_
$a Pancreatic microcirculatory dysfunction emerged as a novel mechanism in the development of hypertension. However, the changes of pancreatic microcirculation profiles in hypertension remain unknown. Pancreatic microcirculatory blood distribution pattern and microvascular vasomotion of spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) were determined by laser Doppler. Wavelet transform analysis was performed to convert micro-hemodynamic signals into time-frequency domains, based on which amplitude spectral scalograms were constructed. The amplitudes of characteristic oscillators were compared between SHRs and WKYs. The expression of eNOS was determined by immunohistochemistry, and plasma nitrite/nitrate levels were measured by Griess reaction. Additionally, endothelin-1, malondialdehyde, superoxide dismutase and interleukin-6 were determined by enzyme-linked immunosorbent assay. SHRs exhibited a lower scale blood distribution pattern with decreased average blood perfusion, frequency and amplitude. Wavelet transform spectral analysis revealed significantly reduced amplitudes of endothelial oscillators. Besides reduced expression of eNOS, the blood microcirculatory chemistry complements micro-hemodynamic profiles as demonstrated by an increase in plasma nitrite/nitrate, endothelin-1, malondialdehyde, interleukin-6 and a decrease of superoxide dismutase in SHRs. Here, we described abnormal pancreatic microcirculation profiles in SHRs, including disarranged blood distribution pattern, impaired microvascular vasomotion and reduced amplitudes of endothelial oscillators.
650    _2
$a zvířata $7 D000818
650    _2
$a krevní tlak $x fyziologie $7 D001794
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a endotelin-1 $x metabolismus $7 D019332
650    _2
$a hypertenze $x patofyziologie $7 D006973
650    _2
$a laser doppler flowmetrie $x metody $7 D017078
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a mikrocirkulace $7 D008833
650    _2
$a oxid dusnatý $x metabolismus $7 D009569
650    _2
$a pankreas $x krevní zásobení $x patofyziologie $7 D010179
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani inbrední SHR $7 D011918
650    _2
$a potkani inbrední WKY $7 D011921
650    _2
$a vlnková analýza $7 D058067
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Li, Yuan $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
700    1_
$a Wang, Bing $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
700    1_
$a Liu, Mingming $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China $u Diabetes Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
700    1_
$a Zhang, Jian $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China $u Diabetes Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
700    1_
$a Li, Ailing $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
700    1_
$a Zhang, Honggang $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
700    1_
$a Xiu, Ruijuan $u Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 69, č. 6 (2020), s. 1039-1049
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33129246 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20211105 $b ABA008
991    __
$a 20211123163015 $b ABA008
999    __
$a ok $b bmc $g 1728756 $s 1148694
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 69 $c 6 $d 1039-1049 $e 20201102 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20211105

Najít záznam

Citační ukazatele

Možnosti archivace