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Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase

V. Vimberg, L. Zieglerova, A. Mazumdar, Z. Szűcs, A. Borbás, P. Herczegh, GB. Novotna

. 2021 ; 14 (11) : . [pub] 20211119

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22001270

Grantová podpora
NV15-28807A Czech Health Research Council
CZ.1.05/1.1.00/02.010 BIOCEV - Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University
GINOP-2.3.2-15-2016-00008 European Regional Development Fund
1 CSRD VA - United States

The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protected in a biofilm environment. In this paper, we compare the in vitro activities of two new semisynthetic glycopeptide antibiotics, MA79 and ERJ390, with two clinically used glycopeptide antibiotics-vancomycin and teicoplanin. The new antibiotics effectively killed not only exponentially growing cells of Staphylococcus aureus, but also cells in the stationary growth phase and biofilm.

Citace poskytuje Crossref.org

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