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Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage

R. Vrzal

. 2021 ; 22 (22) : . [pub] 20211114

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003201

Grantová podpora
NV19-05-00220 Czech Health Research Council

Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung cancer. The purpose of this mini-review is to summarize the basic knowledge about this enzyme in relation to the substrates, inhibitors, genetic polymorphisms, and transcriptional regulation that are known so far (September 2021).

Citace poskytuje Crossref.org

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