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Staphylococcus aureus bloodstream infections: diverging trends of meticillin-resistant and meticillin-susceptible isolates, EU/EEA, 2005 to 2018
C. Gagliotti, LD. Högberg, H. Billström, T. Eckmanns, CG. Giske, OE. Heuer, V. Jarlier, G. Kahlmeter, D. Lo Fo Wong, J. Monen, S. Murchan, GS. Simonsen, M. Šubelj, AT. Andrašević, D. Żabicka, H. Žemličková, DL. Monnet, EARS-Net study group participants
Jazyk angličtina Země Švédsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 1996
Free Medical Journals
od 1995
Freely Accessible Science Journals
od 1995-09-01
PubMed Central
od 2016
Europe PubMed Central
od 2016
Open Access Digital Library
od 1996-01-01
Open Access Digital Library
od 2016-01-01
Medline Complete (EBSCOhost)
od 2010-07-01
ROAD: Directory of Open Access Scholarly Resources
od 1995
- MeSH
- Evropská unie MeSH
- lidé MeSH
- methicilin rezistentní Staphylococcus aureus * MeSH
- methicilin farmakologie MeSH
- sepse * MeSH
- stafylokokové infekce * diagnóza farmakoterapie epidemiologie MeSH
- Staphylococcus aureus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Trends of BSI were assessed at the EU/EEA level by adjusting for blood culture set rate (number of blood culture sets per 1,000 days of hospitalisation) and stratification by patient characteristics.ResultsConsidering a fixed cohort of laboratories consistently reporting data over the entire study period, MRSA percentages among S. aureus BSI decreased from 30.2% in 2005 to 16.3% in 2018. Concurrently, the total number of BSI caused by S. aureus increased by 57%, MSSA BSI increased by 84% and MRSA BSI decreased by 31%. All these trends were statistically significant (p < 0.001).ConclusionsThe results indicate an increasing health burden of MSSA BSI in the EU/EEA despite a significant decrease in the MRSA percentage. These findings highlight the importance of monitoring antimicrobial resistance trends by assessing not only resistance percentages but also the incidence of infections. Further research is needed on the factors associated with the observed trends and on their attributable risk.
Clinical microbiology Växjö Central hospital Växjö Sweden
Department of Epidemiology and Clinical Microbiology National Medicines Institute Warsaw Poland
Department of Microbiology and Infection Control University Hospital of North Norway Tromsø Norway
European Centre for Disease Prevention and Control Solna Sweden
Health Protection Surveillance Centre Dublin Ireland
National Institute for Public Health and the Environment Bilthoven The Netherlands
National Institute of Public Health University of Ljubljana Slovenia
Norwegian Institute of Public Health Oslo Norway
Public Health Agency of Sweden Solna Sweden
Regional Agency for Health and Social Care of Emilia Romagna Bologna Italy
World Health Organization Regional Office for Europe Copenhagen Denmark
Zagreb University Hospital for Infectious Diseases Zagreb Croatia
Citace poskytuje Crossref.org
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- $a BackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Trends of BSI were assessed at the EU/EEA level by adjusting for blood culture set rate (number of blood culture sets per 1,000 days of hospitalisation) and stratification by patient characteristics.ResultsConsidering a fixed cohort of laboratories consistently reporting data over the entire study period, MRSA percentages among S. aureus BSI decreased from 30.2% in 2005 to 16.3% in 2018. Concurrently, the total number of BSI caused by S. aureus increased by 57%, MSSA BSI increased by 84% and MRSA BSI decreased by 31%. All these trends were statistically significant (p < 0.001).ConclusionsThe results indicate an increasing health burden of MSSA BSI in the EU/EEA despite a significant decrease in the MRSA percentage. These findings highlight the importance of monitoring antimicrobial resistance trends by assessing not only resistance percentages but also the incidence of infections. Further research is needed on the factors associated with the observed trends and on their attributable risk.
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