Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Gene-Specific Sex Effects on Susceptibility to Infectious Diseases

M. Lipoldová, P. Demant

. 2021 ; 12 (-) : 712688. [pub] 20211014

Jazyk angličtina Země Švýcarsko

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003457

Inflammation is an integral part of defense against most infectious diseases. These pathogen-induced immune responses are in very many instances strongly influenced by host's sex. As a consequence, sexual dimorphisms were observed in susceptibility to many infectious diseases. They are pathogen dose-dependent, and their outcomes depend on pathogen and even on its species or subspecies. Sex may differentially affect pathology of various organs and its influence is modified by interaction of host's hormonal status and genotype: sex chromosomes X and Y, as well as autosomal genes. In this Mini Review we summarize the major influences of sex in human infections and subsequently focus on 22 autosomal genes/loci that modify in a sex-dependent way the response to infectious diseases in mouse models. These genes have been observed to influence susceptibility to viruses, bacteria, parasites, fungi and worms. Some sex-dependent genes/loci affect susceptibility only in females or only in males, affect both sexes, but have stronger effect in one sex; still other genes were shown to affect the disease in both sexes, but with opposite direction of effect in females and males. The understanding of mechanisms of sex-dependent differences in the course of infectious diseases may be relevant for their personalized management.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22003457
003      
CZ-PrNML
005      
20220127150219.0
007      
ta
008      
220113s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fimmu.2021.712688 $2 doi
035    __
$a (PubMed)34721380
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Lipoldová, Marie $u Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia
245    10
$a Gene-Specific Sex Effects on Susceptibility to Infectious Diseases / $c M. Lipoldová, P. Demant
520    9_
$a Inflammation is an integral part of defense against most infectious diseases. These pathogen-induced immune responses are in very many instances strongly influenced by host's sex. As a consequence, sexual dimorphisms were observed in susceptibility to many infectious diseases. They are pathogen dose-dependent, and their outcomes depend on pathogen and even on its species or subspecies. Sex may differentially affect pathology of various organs and its influence is modified by interaction of host's hormonal status and genotype: sex chromosomes X and Y, as well as autosomal genes. In this Mini Review we summarize the major influences of sex in human infections and subsequently focus on 22 autosomal genes/loci that modify in a sex-dependent way the response to infectious diseases in mouse models. These genes have been observed to influence susceptibility to viruses, bacteria, parasites, fungi and worms. Some sex-dependent genes/loci affect susceptibility only in females or only in males, affect both sexes, but have stronger effect in one sex; still other genes were shown to affect the disease in both sexes, but with opposite direction of effect in females and males. The understanding of mechanisms of sex-dependent differences in the course of infectious diseases may be relevant for their personalized management.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a zvířata $7 D000818
650    _2
$a bakteriální infekce $x epidemiologie $x genetika $7 D001424
650    _2
$a dítě $7 D002648
650    _2
$a infekční nemoci $x epidemiologie $x genetika $7 D003141
650    _2
$a ženské pohlaví $7 D005260
650    12
$a genetická predispozice k nemoci $7 D020022
650    _2
$a pohlavní steroidní hormony $x fyziologie $7 D012739
650    _2
$a helmintóza $x epidemiologie $x genetika $7 D006373
650    _2
$a interakce hostitele a patogenu $x genetika $7 D054884
650    _2
$a lidé $7 D006801
650    _2
$a zánět $7 D007249
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a lidé středního věku $7 D008875
650    _2
$a biologické modely $7 D008954
650    _2
$a mykózy $x epidemiologie $x genetika $7 D009181
650    _2
$a parazitární nemoci $x epidemiologie $x genetika $7 D010272
650    _2
$a lokus kvantitativního znaku $7 D040641
650    12
$a pohlavní dimorfismus $7 D012727
650    _2
$a rozložení podle pohlaví $7 D017678
650    _2
$a druhová specificita $7 D013045
650    _2
$a virové nemoci $x epidemiologie $x genetika $7 D014777
650    _2
$a mladý dospělý $7 D055815
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Demant, Peter $u Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States
773    0_
$w MED00181405 $t Frontiers in immunology $x 1664-3224 $g Roč. 12, č. - (2021), s. 712688
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34721380 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127150215 $b ABA008
999    __
$a ok $b bmc $g 1751036 $s 1154606
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 12 $c - $d 712688 $e 20211014 $i 1664-3224 $m Frontiers in immunology $n Front Immunol $x MED00181405
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Možnosti archivace