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Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments
Ò. Miró, WS. Waring, PI. Dargan, DM. Wood, AM. Dines, C. Yates, I. Giraudon, A. Moughty, N. O'Connor, F. Heyerdahl, KE. Hovda, OM. Vallersnes, R. Paasma, K. Pold, G. Jürgens, B. Megarbane, JS. Anand, E. Liakoni, M. Liechti, F. Eyer, S. Zacharov,...
Jazyk angličtina Země Velká Británie
Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie
- MeSH
- akutní nemoc MeSH
- časové faktory MeSH
- databáze faktografické MeSH
- dospělí MeSH
- hodnocení rizik MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- otrava diagnóza epidemiologie MeSH
- poruchy spojené s užíváním psychoaktivních látek diagnóza epidemiologie MeSH
- registrace MeSH
- rekreační užívání drog trendy MeSH
- rizikové faktory MeSH
- senioři MeSH
- sexuální faktory MeSH
- urgentní služby nemocnice trendy MeSH
- věkové faktory MeSH
- zakázané drogy klasifikace otrava MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- srovnávací studie MeSH
- Geografické názvy
- Evropa MeSH
OBJECTIVE: To analyse the relative percentage of acute recreational drug toxicity emergency department (ED) presentations involving the main drug groups according to age and sex and investigate different patterns based on sex and age strata. METHODS: We analysed all patients with acute recreational drug toxicity included by the Euro-DEN Plus dataset (22 EDs in 14 European countries) between October 2013 and December 2016 (39 months). Drugs were grouped as: opioids, cocaine, cannabis, amphetamines, gamma-hydroxybutyrate (GHB), hallucinogens, new psychoactive substances (NPS), benzodiazepines and ketamine. Descriptive data by age and sex are presented and compared among age/sex categories and among drug families. RESULTS: Of 17,371 patients were included during the 39-month period, 17,198 (99.0%) had taken at least one of the investigated drugs (median age: 31 years; 23.9% female; ethanol co-ingestion recorded in 41.5%, unknown in 31.2%; multiple drug use in 37.9%). Opioids (in 31.4% of patients) and amphetamines (23.3%) were the most frequently involved and hallucinogens (1.9%) and ketamine (1.7%) the least. Overall, female patients were younger than males, both in the whole cohort (median age 29 vs. 32 years; p < 0.001) and in all drug groups except benzodiazepines (median age 36 vs. 36 years; p = 0.83). The relative proportion of each drug group was different at every age strata and some patterns could be clearly described: cannabis, NPS and hallucinogens were the most common in patients <20 years; amphetamines, ketamine and cocaine in the 20- to 39-year group; GHB/GBL in the 30- to 39-year group; and opioids and benzodiazepines in patients ≥40 years. Ethanol and other drug co-ingestion was more frequent at middle-ages, and multidrug co-ingestion was more common in females than males. CONCLUSION: Differences in the drugs involved in acute drug toxicity presentations according to age and sex may be relevant for developing drug-prevention and education programs for some particular subgroups of the population based on the increased risk of adverse events in specific sex and/or age strata.
Acute Medical Unit York Teaching Hospitals NHS Foundation Trust York UK
Clinical Pharmacology Unit Zealand University Hospital Roskilde Roskilde Denmark
Clinical Toxicology Faculty of Life Sciences and Medicine King's College London London UK
Clinical Toxicology Guy's and St Thomas' NHS Foundation Trust and King's Health Partners London UK
Department and Clinical Pharmacology Bispebjerg University Hospital Copenhagen Denmark
Department of Clinical Toxicology Medical University of Gdansk Gdansk Poland
Department of Emergency Medicine Our Lady of Lourdes Hospital Drogheda Republic of Ireland
Department of Prehospital Medicine Oslo University Hospital Oslo Norway
Emergency Department Hospital Clínic IDIBAPS Barcelona Spain
Emergency Department Hospital Son Espases Palma de Mallorca Spain
Emergency Department Mater Dei Hospital Msida Malta
Emergency Department Mater Misericordiae University Hospital Dublin Republic of Ireland
European Monitoring Centre for Drugs and Drug Addiction Lisbon Portugal
Foundation Pärnu Hospital Pärnu Estonia
Medical School Universitat de Barcelona Barcelona Spain
National Toxicological Information Center University Hospital Bratislava Slovakia
North Estonia Medical Centre Tallin Estonia
Pomeranian Centre of Toxicology Gdansk Poland
University Hospital for Emergency Medicine N 1 Pigorov Sofia Bulgaria
Citace poskytuje Crossref.org
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- $a Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments / $c Ò. Miró, WS. Waring, PI. Dargan, DM. Wood, AM. Dines, C. Yates, I. Giraudon, A. Moughty, N. O'Connor, F. Heyerdahl, KE. Hovda, OM. Vallersnes, R. Paasma, K. Pold, G. Jürgens, B. Megarbane, JS. Anand, E. Liakoni, M. Liechti, F. Eyer, S. Zacharov, B. Caganova, J. Bonnici, J. Radenkova-Saeva, M. Galicia, Euro-DEN Plus Research Group
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- $a OBJECTIVE: To analyse the relative percentage of acute recreational drug toxicity emergency department (ED) presentations involving the main drug groups according to age and sex and investigate different patterns based on sex and age strata. METHODS: We analysed all patients with acute recreational drug toxicity included by the Euro-DEN Plus dataset (22 EDs in 14 European countries) between October 2013 and December 2016 (39 months). Drugs were grouped as: opioids, cocaine, cannabis, amphetamines, gamma-hydroxybutyrate (GHB), hallucinogens, new psychoactive substances (NPS), benzodiazepines and ketamine. Descriptive data by age and sex are presented and compared among age/sex categories and among drug families. RESULTS: Of 17,371 patients were included during the 39-month period, 17,198 (99.0%) had taken at least one of the investigated drugs (median age: 31 years; 23.9% female; ethanol co-ingestion recorded in 41.5%, unknown in 31.2%; multiple drug use in 37.9%). Opioids (in 31.4% of patients) and amphetamines (23.3%) were the most frequently involved and hallucinogens (1.9%) and ketamine (1.7%) the least. Overall, female patients were younger than males, both in the whole cohort (median age 29 vs. 32 years; p < 0.001) and in all drug groups except benzodiazepines (median age 36 vs. 36 years; p = 0.83). The relative proportion of each drug group was different at every age strata and some patterns could be clearly described: cannabis, NPS and hallucinogens were the most common in patients <20 years; amphetamines, ketamine and cocaine in the 20- to 39-year group; GHB/GBL in the 30- to 39-year group; and opioids and benzodiazepines in patients ≥40 years. Ethanol and other drug co-ingestion was more frequent at middle-ages, and multidrug co-ingestion was more common in females than males. CONCLUSION: Differences in the drugs involved in acute drug toxicity presentations according to age and sex may be relevant for developing drug-prevention and education programs for some particular subgroups of the population based on the increased risk of adverse events in specific sex and/or age strata.
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