• Je něco špatně v tomto záznamu ?

Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan

A. Mishra, H. Mirzaei, N. Guidi, M. Vinciguerra, A. Mouton, M. Linardic, F. Rappa, R. Barone, G. Navarrete, M. Wei, S. Brandhorst, S. Di Biase, TE. Morgan, S. Ram Kumar, PS. Conti, M. Pellegrini, M. Bernier, R. de Cabo, VD. Longo

. 2021 ; 3 (10) : 1342-1356. [pub] 20211014

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003628

Grantová podpora
P01 AG055369 NIA NIH HHS - United States

Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD), administered every 4 weeks for a period of 2 years, ameliorates the detrimental changes caused by consumption of a high-fat, high-calorie diet (HFCD) in female mice. We demonstrate that monthly FMD cycles inhibit HFCD-mediated obesity by reducing the accumulation of visceral and subcutaneous fat without causing loss of lean body mass. FMD cycles increase cardiac vascularity and function and resistance to cardiotoxins, prevent HFCD-dependent hyperglycaemia, hypercholesterolaemia and hyperleptinaemia and ameliorate impaired glucose and insulin tolerance. The effect of monthly FMD cycles on gene expression associated with mitochondrial metabolism and biogenesis in adipocytes and the sustained ketogenesis in HFCD-fed mice indicate a role for fat cell reprogramming in obesity prevention. These effects of an FMD on adiposity and cardiac ageing could explain the protection from HFCD-dependent early mortality.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22003628
003      
CZ-PrNML
005      
20220127150043.0
007      
ta
008      
220113s2021 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s42255-021-00469-6 $2 doi
035    __
$a (PubMed)34650272
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Mishra, Amrendra $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
245    10
$a Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan / $c A. Mishra, H. Mirzaei, N. Guidi, M. Vinciguerra, A. Mouton, M. Linardic, F. Rappa, R. Barone, G. Navarrete, M. Wei, S. Brandhorst, S. Di Biase, TE. Morgan, S. Ram Kumar, PS. Conti, M. Pellegrini, M. Bernier, R. de Cabo, VD. Longo
520    9_
$a Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD), administered every 4 weeks for a period of 2 years, ameliorates the detrimental changes caused by consumption of a high-fat, high-calorie diet (HFCD) in female mice. We demonstrate that monthly FMD cycles inhibit HFCD-mediated obesity by reducing the accumulation of visceral and subcutaneous fat without causing loss of lean body mass. FMD cycles increase cardiac vascularity and function and resistance to cardiotoxins, prevent HFCD-dependent hyperglycaemia, hypercholesterolaemia and hyperleptinaemia and ameliorate impaired glucose and insulin tolerance. The effect of monthly FMD cycles on gene expression associated with mitochondrial metabolism and biogenesis in adipocytes and the sustained ketogenesis in HFCD-fed mice indicate a role for fat cell reprogramming in obesity prevention. These effects of an FMD on adiposity and cardiac ageing could explain the protection from HFCD-dependent early mortality.
650    _2
$a zvířata $7 D000818
650    _2
$a kardiovaskulární nemoci $x metabolismus $x patologie $7 D002318
650    12
$a dieta s vysokým obsahem tuků $7 D059305
650    12
$a omezení příjmu potravy $7 D005215
650    _2
$a ženské pohlaví $7 D005260
650    12
$a dlouhověkost $7 D008136
650    _2
$a metabolické nemoci $x metabolismus $x patologie $7 D008659
650    _2
$a myši $7 D051379
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a Research Support, N.I.H., Intramural $7 D052060
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Mirzaei, Hamed $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
700    1_
$a Guidi, Novella $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
700    1_
$a Vinciguerra, Manlio $u International Clinical Research Center, St Anne's University Hospital, Brno, Czech Republic
700    1_
$a Mouton, Alice $u Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA
700    1_
$a Linardic, Marina $u Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA
700    1_
$a Rappa, Francesca $u Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy
700    1_
$a Barone, Rosario $u Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy
700    1_
$a Navarrete, Gerardo $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
700    1_
$a Wei, Min $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
700    1_
$a Brandhorst, Sebastian $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
700    1_
$a Di Biase, Stefano $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
700    1_
$a Morgan, Todd E $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
700    1_
$a Ram Kumar, S $u Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
700    1_
$a Conti, Peter S $u Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
700    1_
$a Pellegrini, Matteo $u Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA
700    1_
$a Bernier, Michel $u Translational Gerontology Branch, Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
700    1_
$a de Cabo, Rafael $u Translational Gerontology Branch, Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
700    1_
$a Longo, Valter D $u Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. vlongo@usc.edu $u IFOM, FIRC Institute of Molecular Oncology, Milano, Italy. vlongo@usc.edu
773    0_
$w MED00207066 $t Nature metabolism $x 2522-5812 $g Roč. 3, č. 10 (2021), s. 1342-1356
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34650272 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127150039 $b ABA008
999    __
$a ok $b bmc $g 1751172 $s 1154777
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 3 $c 10 $d 1342-1356 $e 20211014 $i 2522-5812 $m Nature metabolism $n Nat Metab $x MED00207066
GRA    __
$a P01 AG055369 $p NIA NIH HHS $2 United States
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

    Možnosti archivace