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On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer's Disease
J. Kriska, Z. Hermanova, T. Knotek, J. Tureckova, M. Anderova
Language English Country Switzerland
Document type Journal Article, Review
Grant support
21-24674S
Grantová Agentura České Republiky
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
34575845
DOI
10.3390/ijms22189689
Knihovny.cz E-resources
- MeSH
- Alzheimer Disease etiology metabolism pathology MeSH
- Amyloid beta-Peptides metabolism MeSH
- Biomarkers MeSH
- Nerve Degeneration MeSH
- Brain Ischemia etiology metabolism pathology MeSH
- Humans MeSH
- Disease Susceptibility * MeSH
- Neurons metabolism MeSH
- Brain Injuries etiology metabolism pathology MeSH
- Wnt Signaling Pathway MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Ischemic brain injury and Alzheimer's disease (AD) both lead to cell death in the central nervous system (CNS) and thus negatively affect particularly the elderly population. Due to the lack of a definitive cure for brain ischemia and AD, it is advisable to carefully study, compare, and contrast the mechanisms that trigger, and are involved in, both neuropathologies. A deeper understanding of these mechanisms may help ameliorate, or even prevent, the destructive effects of neurodegenerative disorders. In this review, we deal with ischemic damage and AD, with the main emphasis on the common properties of these CNS disorders. Importantly, we discuss the Wnt signaling pathway as a significant factor in the cell fate determination and cell survival in the diseased adult CNS. Finally, we summarize the interesting findings that may improve or complement the current sparse and insufficient treatments for brain ischemia and AD, and we delineate prospective directions in regenerative medicine.
2nd Faculty of Medicine Charles University 150 06 Prague Czech Republic
Institute of Experimental Medicine Czech Academy of Sciences 142 20 Prague Czech Republic
References provided by Crossref.org
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