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Pleomorphic adenoma: the great mimicker of malignancy

JC. Hernandez-Prera, A. Skálová, A. Franchi, A. Rinaldo, V. Vander Poorten, P. Zbären, A. Ferlito, BM. Wenig

. 2021 ; 79 (3) : 279-290. [pub] 20210422

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003816

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm, and its diagnosis is straightforward in the majority of cases. However, not infrequently, PA shows unusual and uncommon histological features that can be confused with those of malignancy. The difficulties in diagnosing PA arise from its ability to mimic invasion, show atypical or metaplastic cytomorphology, and show morphological features that overlap with those of established salivary gland carcinomas. In addition, recognising early malignant transformation to carcinoma ex-pleomorphic adenoma continues to be a frequent challenge. This review describes the diagnostic pitfalls of PA, and offers a systematic approach to avoid them by combining classic histopathology with novel immunohistochemical and molecular tests.

Citace poskytuje Crossref.org

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$a Skálová, Alena $u Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic
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$a Franchi, Alessandro $u Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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$a Rinaldo, Alessandra $u Department of Otolaryngology, University of Udine, Udine, Italy
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$a Zbären, Peter $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital, Bern, Switzerland
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$a Wenig, Bruce M $u Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA
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