• Je něco špatně v tomto záznamu ?

Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

A. Khairnar, J. Ruda-Kucerova, A. Arab, C. Hadjistyllis, A. Sejnoha Minsterova, Q. Shang, A. Chovsepian, E. Drazanova, N. Szabó, Z. Starcuk, I. Rektorova, F. Pan-Montojo

. 2021 ; 158 (3) : 779-797. [pub] 20210705

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004016

Clinical diagnosis of Parkinson's disease (PD) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (SN) already died, and the first motor symptoms appear. Therefore, tools enabling the early diagnosis of PD are essential to identify early-stage PD patients in which neuroprotective treatments could have a significant impact. Here, we test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone, a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging. Our results show that DKI, especially kurtosis, can detect the progression of pathology-associated changes throughout the CNS. Increases in mean kurtosis were first observed in the dorsal motor nucleus of the vagus (DMV) after 2 months of exposure to rotenone and before the loss of dopaminergic neurons in the SN occurred. Remarkably, we also show that limited exposure to rotenone for 2 months is enough to trigger the progression of the disease in the absence of the environmental toxin, thus suggesting that once the first pathological changes in one region appear, they can self-perpetuate and progress within the CNS. Overall, our results show that DKI can be a useful radiological marker for the early detection and monitoring of PD pathology progression in patients with the potential to improve the clinical diagnosis and the development of neuroprotective treatments.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004016
003      
CZ-PrNML
005      
20220127145633.0
007      
ta
008      
220113s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/jnc.15449 $2 doi
035    __
$a (PubMed)34107061
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Khairnar, Amit $u Applied Neuroscience Research Group, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic $u Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, India
245    10
$a Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease / $c A. Khairnar, J. Ruda-Kucerova, A. Arab, C. Hadjistyllis, A. Sejnoha Minsterova, Q. Shang, A. Chovsepian, E. Drazanova, N. Szabó, Z. Starcuk, I. Rektorova, F. Pan-Montojo
520    9_
$a Clinical diagnosis of Parkinson's disease (PD) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (SN) already died, and the first motor symptoms appear. Therefore, tools enabling the early diagnosis of PD are essential to identify early-stage PD patients in which neuroprotective treatments could have a significant impact. Here, we test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone, a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging. Our results show that DKI, especially kurtosis, can detect the progression of pathology-associated changes throughout the CNS. Increases in mean kurtosis were first observed in the dorsal motor nucleus of the vagus (DMV) after 2 months of exposure to rotenone and before the loss of dopaminergic neurons in the SN occurred. Remarkably, we also show that limited exposure to rotenone for 2 months is enough to trigger the progression of the disease in the absence of the environmental toxin, thus suggesting that once the first pathological changes in one region appear, they can self-perpetuate and progress within the CNS. Overall, our results show that DKI can be a useful radiological marker for the early detection and monitoring of PD pathology progression in patients with the potential to improve the clinical diagnosis and the development of neuroprotective treatments.
650    _2
$a aplikace orální $7 D000284
650    _2
$a zvířata $7 D000818
650    _2
$a zobrazování difuzních tenzorů $x metody $7 D056324
650    12
$a progrese nemoci $7 D018450
650    _2
$a dopaminergní neurony $x účinky léků $x patologie $7 D059290
650    _2
$a insekticidy $x toxicita $7 D007306
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a bludiště - učení $x účinky léků $x fyziologie $7 D018782
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a parkinsonské poruchy $x chemicky indukované $x diagnostické zobrazování $x patologie $7 D020734
650    _2
$a rotenon $x aplikace a dávkování $x toxicita $7 D012402
650    _2
$a časové faktory $7 D013997
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Ruda-Kucerova, Jana $u Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Arab, Anas $u Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Hadjistyllis, Constantinos $u Department of Neurology, University Hospital, LMU Munich, Munich, Germany
700    1_
$a Sejnoha Minsterova, Alzbeta $u Applied Neuroscience Research Group, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic $u Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Shang, Qi $u Department of Neurology, University Hospital, LMU Munich, Munich, Germany
700    1_
$a Chovsepian, Alexandra $u Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
700    1_
$a Drazanova, Eva $u Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Institute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech Republic
700    1_
$a Szabó, Nikoletta $u Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary $u Multi-modal and Functional Neuroimaging Group, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Starcuk, Zenon $u Institute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech Republic
700    1_
$a Rektorova, Irena $u Applied Neuroscience Research Group, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Pan-Montojo, Francisco $u Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany $u Department of Neurology, University Hospital, LMU Munich, Munich, Germany
773    0_
$w MED00002832 $t Journal of neurochemistry $x 1471-4159 $g Roč. 158, č. 3 (2021), s. 779-797
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34107061 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145629 $b ABA008
999    __
$a ok $b bmc $g 1751472 $s 1155165
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 158 $c 3 $d 779-797 $e 20210705 $i 1471-4159 $m Journal of neurochemistry $n J Neurochem $x MED00002832
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Možnosti archivace