Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

In Vitro Characterization of Poly(Lactic Acid)/ Poly(Hydroxybutyrate)/ Thermoplastic Starch Blends for Tissue Engineering Application

M. Culenova, I. Birova, P. Alexy, P. Galfyova, A. Nicodemou, B. Moncmanova, R. Plavec, K. Tomanova, P. Mencik, S. Ziaran, L. Danisovic

. 2021 ; 30 (-) : 9636897211021003. [pub] -

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004693

Complex in vitro characterization of a blended material based on Poly(Lactic Acid), Poly(Hydroxybutyrate), and Thermoplastic Starch (PLA/PHB/TPS) was performed in order to evaluate its potential for application in the field of tissue engineering. We focused on the biological behavior of the material as well as its mechanical and morphological properties. We also focused on the potential of the blend to be processed by the 3D printer which would allow the fabrication of the custom-made scaffold. Several blends recipes were prepared and characterized. This material was then studied in the context of scaffold fabrication. Scaffold porosity, wettability, and cell-scaffold interaction were evaluated as well. MTT test and the direct contact cytotoxicity test were applied in order to evaluate the toxic potential of the blended material. Biocompatibility studies were performed on the human chondrocytes. According to our results, we assume that material had no toxic effect on the cell culture and therefore could be considered as biocompatible. Moreover, PLA/PHB/TPS blend is applicable for 3D printing. Printed scaffolds had highly porous morphology and were able to absorb water as well. In addition, cells could adhere and proliferate on the scaffold surface. We conclude that this blend has potential for scaffold engineering.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004693
003      
CZ-PrNML
005      
20220127145044.0
007      
ta
008      
220113s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1177/09636897211021003 $2 doi
035    __
$a (PubMed)34053231
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Culenova, Martina $u Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovak Republic
245    10
$a In Vitro Characterization of Poly(Lactic Acid)/ Poly(Hydroxybutyrate)/ Thermoplastic Starch Blends for Tissue Engineering Application / $c M. Culenova, I. Birova, P. Alexy, P. Galfyova, A. Nicodemou, B. Moncmanova, R. Plavec, K. Tomanova, P. Mencik, S. Ziaran, L. Danisovic
520    9_
$a Complex in vitro characterization of a blended material based on Poly(Lactic Acid), Poly(Hydroxybutyrate), and Thermoplastic Starch (PLA/PHB/TPS) was performed in order to evaluate its potential for application in the field of tissue engineering. We focused on the biological behavior of the material as well as its mechanical and morphological properties. We also focused on the potential of the blend to be processed by the 3D printer which would allow the fabrication of the custom-made scaffold. Several blends recipes were prepared and characterized. This material was then studied in the context of scaffold fabrication. Scaffold porosity, wettability, and cell-scaffold interaction were evaluated as well. MTT test and the direct contact cytotoxicity test were applied in order to evaluate the toxic potential of the blended material. Biocompatibility studies were performed on the human chondrocytes. According to our results, we assume that material had no toxic effect on the cell culture and therefore could be considered as biocompatible. Moreover, PLA/PHB/TPS blend is applicable for 3D printing. Printed scaffolds had highly porous morphology and were able to absorb water as well. In addition, cells could adhere and proliferate on the scaffold surface. We conclude that this blend has potential for scaffold engineering.
650    _2
$a lidé $7 D006801
650    _2
$a hydroxybutyráty $x farmakologie $x terapeutické užití $7 D006885
650    _2
$a polyestery $x farmakologie $x terapeutické užití $7 D011091
650    _2
$a 3D tisk $7 D066330
650    _2
$a tkáňové inženýrství $x metody $7 D023822
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Birova, Ivana $u Institute of Natural and Synthetic Polymers, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Slovak Republic
700    1_
$a Alexy, Pavol $u Institute of Natural and Synthetic Polymers, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Slovak Republic
700    1_
$a Galfyova, Paulina $u Institute of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovak Republic
700    1_
$a Nicodemou, Andreas $u Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovak Republic
700    1_
$a Moncmanova, Barbora $u Institute of Natural and Synthetic Polymers, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Slovak Republic
700    1_
$a Plavec, Roderik $u Institute of Natural and Synthetic Polymers, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Slovak Republic
700    1_
$a Tomanova, Katarina $u Institute of Natural and Synthetic Polymers, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Slovak Republic
700    1_
$a Mencik, Premysl $u Institute of Materials Science, Faculty of Chemistry, Brno University of Technology, 612 00 Brno, Czech Republic
700    1_
$a Ziaran, Stanislav $u Department of Urology, Faculty of Medicine, Comenius University in Bratislava, 833 05 Bratislava, Slovak Republic
700    1_
$a Danisovic, Lubos $u Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovak Republic $u Regenmed Ltd., 811 02 Bratislava, Slovak Republic
773    0_
$w MED00001075 $t Cell transplantation $x 1555-3892 $g Roč. 30, č. - (2021), s. 9636897211021003
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34053231 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145041 $b ABA008
999    __
$a ok $b bmc $g 1751997 $s 1155842
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 30 $c - $d 9636897211021003 $e - $i 1555-3892 $m Cell transplantation $n Cell Transplant $x MED00001075
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Možnosti archivace