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Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives

AMAE. El-Azzouny, MN. Aboul-Enein, MF. Hamissa

. 2020 ; 81 (7) : 786-802. [pub] 20200508

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004819

Grantová podpora
17-00121S Grantová Agentura České Republiky - International
CZ.02.1.01/0.0/0.0/16_019/0000 729 European Regional Development Fund - International
Czech Science Foundation - International
National Research Centre - International

The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, anticancer, sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.

Citace poskytuje Crossref.org

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